4.2.1.118: 3-dehydroshikimate dehydratase
This is an abbreviated version!
For detailed information about 3-dehydroshikimate dehydratase, go to the full flat file.
Word Map on EC 4.2.1.118
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4.2.1.118
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protocatechuate
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quinate
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glutamicum
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corynebacterium
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lignin
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crassa
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quinic
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saccharification
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nylon
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bioproducts
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adipic
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qa
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muconic
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7-phosphate
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polyurethan
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co-product
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petrochemicals
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3,4-dihydroxybenzoate
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terephthalic
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podospora
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feedback-resistant
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bioenergy
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3-dehydroquinate
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cis,cis-muconic
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synthesis
- 4.2.1.118
- protocatechuate
- quinate
- glutamicum
- corynebacterium
- lignin
- crassa
-
quinic
-
saccharification
-
nylon
-
bioproducts
-
adipic
- qa
-
muconic
- 7-phosphate
-
polyurethan
-
co-product
-
petrochemicals
- 3,4-dihydroxybenzoate
-
terephthalic
-
podospora
-
feedback-resistant
-
bioenergy
- 3-dehydroquinate
-
cis,cis-muconic
- synthesis
Reaction
Synonyms
(-)-3-dehydroshikimate dehydratase, 3-dehydroshikimate dehydratase, AroZ, AsbF, BT246_21860, dehydroshikimate dehydratase, DHSase, DSD, mDSD, membrane-bound 3-dehydroshikimate dehydratase, Qa-1, QsuB, Qui1, quiC1, quiC_1, QutC
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Application
Application on EC 4.2.1.118 - 3-dehydroshikimate dehydratase
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synthesis
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introduction of both 3-dehydroshikimate dehydratase and protocatechuic acid decarboxylase into an Escherichia coli construct synthesizing elevated levles of 3-dehydroshikimic acid leads to production of up to 18.5 mM catechol from 56 mM D-glucose on 1 l-scale
synthesis
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production of vanillin by engineered pathway in Schizosaccharomyces pombe or Saccharomyces cerevisiae. Pathway involves incorporation of 3-dehydroshikimate dehydratase, an aromatic carboxylic acid reductase from a bacterium of the Nocardia genus, and an O-ethyltransferase from Homo sapiens. In Saccharomyces cerevisiae, the aromatic carboxylic acid reductase enzyme requires activation by phosphopantetheinylation, achieved by coexpression of a Corynebacterium glutamicum phosphopantetheinyl transferase. Prevention of reduction of vanillin to vanillyl alcohol is achieved by knockout of the host alcohol dehydrogenase ADH6. In Schizosaccharomyces pombe, the biosynthesis is further improved by introduction of an Arabidopsis thaliana family 1 UDPglycosyltransferase, converting vanillin into vanillin beta-D-glucoside, which is not toxic to the yeast cells and thus may be accumulated in larger amounts