4.2.1.118: 3-dehydroshikimate dehydratase

This is an abbreviated version!
For detailed information about 3-dehydroshikimate dehydratase, go to the full flat file.

Word Map on EC 4.2.1.118

4.2.1.118

protocatechuate

quinate

glutamicum

corynebacterium

lignin

crassa

quinic

saccharification

nylon

bioproducts

adipic

qa

muconic

7-phosphate

polyurethan

co-product

petrochemicals

3,4-dihydroxybenzoate

terephthalic

podospora

feedback-resistant

bioenergy

3-dehydroquinate

cis,cis-muconic

synthesis

Reaction

Synonyms

(-)-3-dehydroshikimate dehydratase, 3-dehydroshikimate dehydratase, AroZ, AsbF, BT246_21860, dehydroshikimate dehydratase, DHSase, DSD, mDSD, membrane-bound 3-dehydroshikimate dehydratase, Qa-1, QsuB, Qui1, quiC1, quiC_1, QutC

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.118 3-dehydroshikimate dehydratase

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Results	in table
4465	AA Sequence
2	Application
1	CAS Registry Number
9	Cloned(Commentary)
1	Cofactor
13	General Information
2	General Stability
7	Inhibitors
6	kcat/KM [mM/s]
9	KM Value [mM]
5	Localization
12	Metals/Ions
4	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
19	Organism
10	Pathway
6	PDB ID
6	pH Optimum
1	pH Range
2	pI Value
9	Protein Variants
3	Purification (Commentary)
1	Reaction
16	Reference
1	Renatured (Commentary)
1	Source Tissue
1	Specific Activity [micromol/min/mg]
2	Storage Stability
15	Substrates and Products (Substrate)
7	Subunits
34	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
5	Temperature Stability [°C]
7	Turnover Number [1/s]

Reference

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Reference on EC 4.2.1.118 - 3-dehydroshikimate dehydratase

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695772

Hansen, E.H.; Moeller, B.L.; Kock, G.R.; Bunner, C.M.; Kristensen, C.; Jensen, O.R.; Okkels, F.T.; Olsen, C.E.; Motawia, M.S.; Hansen, J.

De novo biosynthesis of vanillin in fission yeast (Schizosaccharomyces pombe) and baker's yeast (Saccharomyces cerevisiae)

Appl. Environ. Microbiol.

2765-2774

2009

Podospora pauciseta

19286778

696074

Lamb, H.K.; Van den Hombergh, J.P.T.W.; Newton, G.H.; Moore, J.D.; Roberts, C.F.; Hawkins, A.R.

Differential flux through the quinate and shikimate pathways. Implications for the channeling hypothesis

Biochem. J.

284

181-187

1992

Aspergillus nidulans

696233

Fox, D.T.; Hotta, K.; Kim, C.Y.; Koppisch, A.T.

The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase

Biochemistry

12251-12253

2008

Bacillus thuringiensis, Bacillus thuringiensis 97-27

18975921

698089

Rutledge, B.

Molecular characterization of the qa-4 gene of Neurospora crassa

Gene

275-287

1984

Neurospora crassa

6241580

698450

Draths, K.; Frost, J.

Environmentally compatible synthesis of catechol from D-glucose

J. Am. Chem. Soc.

117

2395-2400

1995

Klebsiella pneumoniae

698683

Stroeman, P.; Reinert, W.R.; Giles, N.H.

Purification and characterization of 3-dehydroshikimate dehydratase, an enzyme in the inducible quinic acid catabolic pathway of Neurospora crassa

J. Biol. Chem.

253

4593-4598

1978

Neurospora crassa

149131

700722

Tateoka, T.; Yasuda, I.

3-Dehydroshikimate dehydratase in mung bean cultured cells

Plant Cell Rep.

212-217

1995

Vigna mungo

24185778

714521

Shinagawa, E.; Adachi, O.; Ano, Y.; Yakushi, T.; Matsushita, K.

Purification and characterization of membrane-bound 3-dehydroshikimate dehydratase from Gluconobacter oxydans IFO 3244, a new enzyme catalyzing extracellular protocatechuate formation

Biosci. Biotechnol. Biochem.

1084-1088

2010

Gluconobacter oxydans, Gluconacetobacter liquefaciens, Gluconobacter oxydans IFO 3244

20460715

746603

Harrington, L.B.; Jha, R.K.; Kern, T.L.; Schmidt, E.N.; Canales, G.M.; Finney, K.B.; Koppisch, A.T.; Strauss, C.E.; Fox, D.T.

Rapid thermostabilization of Bacillus thuringiensis serovar Konkukian 97-27 dehydroshikimate dehydratase through a structure-based enzyme design and whole cell activity assay

ACS Synth. Biol.

120-129

2017

Bacillus thuringiensis (A0A1B1L4G3)

27548779

748670

Peek, J.; Roman, J.; Moran, G.R.; Christendat, D.

Structurally diverse dehydroshikimate dehydratase variants participate in microbial quinate catabolism

Mol. Microbiol.

103

39-54

2017

Pseudomonas aeruginosa, Pseudomonas putida (A0A379KX44), Pseudomonas putida, Bacillus anthracis (Q81RQ4)

27706847

748901

Eudes, A.; Sathitsuksanoh, N.; Baidoo, E.E.; George, A.; Liang, Y.; Yang, F.; Singh, S.; Keasling, J.D.; Simmons, B.A.; Loque, D.

Expression of a bacterial 3-dehydroshikimate dehydratase reduces lignin content and improves biomass saccharification efficiency

Plant Biotechnol. J.

1241-1250

2015

Corynebacterium glutamicum

25583257