4.1.3.30: Methylisocitrate lyase

This is an abbreviated version!
For detailed information about Methylisocitrate lyase, go to the full flat file.

Word Map on EC 4.1.3.30

4.1.3.30

propionate

methylcitrate

tuberculosis

propionyl-coa

dehydratase

glyoxylate

prpc

lyases

acetyl-coa

typhimurium

mutase

odd-chain

3-bromopyruvate

beta-oxidation

enterica

Reaction

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate

Synonyms

2-Methylisocitrate lyase, Lyase, methylisocitrate, MCL, Mcl1, methylisocitrate lyase, MICL, mmgF, PrpB, TgPrpB, yqiQ

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.3 Oxo-acid-lyases

4.1.3.30 Methylisocitrate lyase

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Results	in table
3	Activating Compound
11293	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
1	Cofactor
3	Crystallization (Commentary)
2	Expression
18	General Information
1	General Stability
28	Inhibitors
4	kcat/KM [mM/s]
1	Ki Value [mM]
12	KM Value [mM]
6	Localization
7	Metals/Ions
7	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
73	Organism
1	Oxidation Stability
6	Pathway
62	PDB ID
3	pH Optimum
3	pH Range
1	pH Stability
1	Posttranslational Modification
13	Protein Variants
5	Purification (Commentary)
3	Reaction
1	Reaction Type
44	Reference
1	Source Tissue
12	Specific Activity [micromol/min/mg]
58	Substrates and Products (Substrate)
4	Subunits
30	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
9	Temperature Stability [°C]
8	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 4.1.3.30 - Methylisocitrate lyase

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(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate

19 entries

(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate

Pyruvate + succinate

Aspergillus nidulans

one of the key enzymes of the methylcitrate cycle. Deletion mutants do not grow on propionate as sole carbon and energy source and are severely inhibited during growth on alternative carbon sources, when propionate is present. The strongest inhibitory effect is observed, when glycerol is the main carbon source, followed by glucose and acetate. In addition, asexual conidiation is strongly impaired in the presence of propionate

663709

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate

succinate + pyruvate

5 entries

2-methylisocitrate

succinate + pyruvate

2 entries

additional information

7 entries