4.1.3.30: Methylisocitrate lyase

This is an abbreviated version!
For detailed information about Methylisocitrate lyase, go to the full flat file.

Word Map on EC 4.1.3.30

4.1.3.30

propionate

methylcitrate

tuberculosis

propionyl-coa

dehydratase

glyoxylate

prpc

lyases

acetyl-coa

typhimurium

mutase

odd-chain

3-bromopyruvate

beta-oxidation

enterica

Reaction

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate

Synonyms

2-Methylisocitrate lyase, Lyase, methylisocitrate, MCL, Mcl1, methylisocitrate lyase, MICL, mmgF, PrpB, TgPrpB, yqiQ

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.3 Oxo-acid-lyases

4.1.3.30 Methylisocitrate lyase

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Results	in table
3	Activating Compound
11293	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
1	Cofactor
3	Crystallization (Commentary)
2	Expression
18	General Information
1	General Stability
28	Inhibitors
4	kcat/KM [mM/s]
1	Ki Value [mM]
12	KM Value [mM]
6	Localization
7	Metals/Ions
7	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
73	Organism
1	Oxidation Stability
6	Pathway
62	PDB ID
3	pH Optimum
3	pH Range
1	pH Stability
1	Posttranslational Modification
13	Protein Variants
5	Purification (Commentary)
3	Reaction
1	Reaction Type
44	Reference
1	Source Tissue
12	Specific Activity [micromol/min/mg]
58	Substrates and Products (Substrate)
4	Subunits
30	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
9	Temperature Stability [°C]
8	Turnover Number [1/s]

KI Value

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KI Value on EC 4.1.3.30 - Methylisocitrate lyase

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additional information

Aspergillus fumigatus

0.258 mM isocitrate required to double the KM-value with methylisocitrate (wild type protein), 0.0598 mM isocitrate required to double the KM-value with methylisocitrate (L521F mutant protein), 0.0606 mM isocitrate required to double the KM-value with methylisocitrate (S523T mutant protein), 0.0119 mM isocitrate required to double the KM-value with methylisocitrate (L521F/L521F mutant protein)

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