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4.1.1.72: branched-chain-2-oxoacid decarboxylase

This is an abbreviated version!
For detailed information about branched-chain-2-oxoacid decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.72

Reaction

(3S)-3-methyl-2-oxopentanoate
=
2-methylbutanal
 +
CO2

Synonyms

alpha-keto acid decarboxylase, AlsS, BCKA, BCKAD, BCKDC, branched-chain 2-keto acid decarboxylase, branched-chain 2-oxoacid decarboxylase, branched-chain alpha-keto acid decarboxylase, branched-chain alpha-ketoacid dehydrogenase complex, branched-chain keto acid decarboxylase, branched-chain oxo acid decarboxylase, decarboxylase, branched-chain oxo acid, KDC, KdcA, MtKDC, THI3, thiamine metabolism regulatory protein, YDL080c

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.72 branched-chain-2-oxoacid decarboxylase

Temperature Stability

Temperature Stability on EC 4.1.1.72 - branched-chain-2-oxoacid decarboxylase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40
-
sufficiently stable up to 40°C, but rapidly loses activity at higher temperatures
61
wild-type, melting temperature
64
mutant V461I, melting temperature
66.5
mutant V461I/A290M, melting temperature
70.5
mutant V461I/A290M/Q252N/D306G/E316R/F388Y, melting temperature
75.5
mutant V461I/A290M/Q252N/D306G/E316R/F388Y/I404C, melting temperature