4.1.1.72: branched-chain-2-oxoacid decarboxylase

This is an abbreviated version!
For detailed information about branched-chain-2-oxoacid decarboxylase, go to the full flat file.

Reaction

Synonyms

alpha-keto acid decarboxylase, AlsS, BCKA, BCKAD, BCKDC, branched-chain 2-keto acid decarboxylase, branched-chain 2-oxoacid decarboxylase, branched-chain alpha-keto acid decarboxylase, branched-chain alpha-ketoacid dehydrogenase complex, branched-chain keto acid decarboxylase, branched-chain oxo acid decarboxylase, decarboxylase, branched-chain oxo acid, KDC, KdcA, MtKDC, THI3, thiamine metabolism regulatory protein, YDL080c

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.72 branched-chain-2-oxoacid decarboxylase

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Results	in table
3	Activating Compound
88	AA Sequence
9	Application
1	CAS Registry Number
9	Cloned(Commentary)
8	Cofactor
1	Crystallization (Commentary)
43	Disease/ Diagnostics
3	General Information
9	Inhibitors
10	kcat/KM [mM/s]
1	Ki Value [mM]
68	KM Value [mM]
3	Localization
6	Metals/Ions
24	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
39	Organism
8	Pathway
7	pH Optimum
4	pH Range
3	pH Stability
1	Posttranslational Modification
36	Protein Variants
9	Purification (Commentary)
2	Reaction
1	Reaction Type
35	Reference
2	Renatured (Commentary)
3	Source Tissue
2	Specific Activity [micromol/min/mg]
116	Substrates and Products (Substrate)
18	Subunits
40	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
9	Temperature Stability [°C]
58	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 4.1.1.72 - branched-chain-2-oxoacid decarboxylase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1,10-phenanthroline

Lactococcus lactis subsp. lactis

Q684J7

10 mM, 4.5% residual activity

664985

2-[(R)-1-hydroxyethyl]deaza thiamine diphosphate

Lactococcus lactis

-

0.1 mM

677319

4-hydroxymercuribenzoic acid

Lactococcus lactis subsp. lactis

Q684J7

1 mM, 59% residual activity

664985

Cu2+

Lactococcus lactis subsp. lactis

Q684J7

1 mM, 5.2% residual activity

664985

EDTA

Lactococcus lactis subsp. lactis

Q684J7

1 mM, 4.3% residual activity

664985

phenylmethanesulfonyl fluoride

Lactococcus lactis subsp. lactis

Q684J7

1 mM, 71.7% residual activity

664985

phosphoramidon

Lactococcus lactis subsp. lactis

Q684J7

1 mM, 52% residual activity

664985

pyruvate

Mycobacterium tuberculosis

P9WG37

weak substrate inhibition

693210

Zn2+

Lactococcus lactis subsp. lactis

Q684J7

1 mM, 66% residual activity

664985