4.1.1.72: branched-chain-2-oxoacid decarboxylase
This is an abbreviated version!
For detailed information about branched-chain-2-oxoacid decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.72
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4.1.1.72
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alpha-ketoacid
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maple
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syrup
-
acidosis
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alpha-ketoisocaproate
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ketoacids
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cheese
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alpha-ketoisovalerate
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e1alpha
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bckas
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dihydrolipoyl
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transacylase
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alpha-keto-beta-methylvalerate
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synthesis
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medicine
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agriculture
- 4.1.1.72
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alpha-ketoacid
-
maple
- syrup
- acidosis
- alpha-ketoisocaproate
-
ketoacids
-
cheese
- alpha-ketoisovalerate
- e1alpha
-
bckas
-
dihydrolipoyl
-
transacylase
- alpha-keto-beta-methylvalerate
- synthesis
- medicine
- agriculture
Reaction
Synonyms
alpha-keto acid decarboxylase, AlsS, BCKA, BCKAD, BCKDC, branched-chain 2-keto acid decarboxylase, branched-chain 2-oxoacid decarboxylase, branched-chain alpha-keto acid decarboxylase, branched-chain alpha-ketoacid dehydrogenase complex, branched-chain keto acid decarboxylase, branched-chain oxo acid decarboxylase, decarboxylase, branched-chain oxo acid, KDC, KdcA, MtKDC, THI3, thiamine metabolism regulatory protein, YDL080c
ECTree
4.1.1.72 branched-chain-2-oxoacid decarboxylaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 4.1.1.72 - branched-chain-2-oxoacid decarboxylase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-oxo-3-methylvalerate
2-methylbutanal + CO2
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the enzymatic activity toward 2-oxo-3-methylvalerate is 1.5times higher than the activity toward 2-oxo-isovalerate
-
-
?
2-oxo-3-phenylpropanoic acid
phenylacetaldehyde + CO2
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at 30 mM 8.6% activity relative to 3-methyl-2-oxobutanoic acid
-
-
?
2-oxoglutarate
CO2 + succinate semialdehyde
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5% of the activity with L-3-methyl-2-oxopentanoate
-
-
?
2-oxoisopentanoate
CO2 + isobutanal
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63% of the activity with L-3-methyl-
-
-
?
2-oxopropanoic acid
acetaldehyde + CO2
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at 30 mM 1.2% activity relative to 3-methyl-2-oxobutanoic acid
-
-
?
3,5-dimethoxybenzaldehyde + 2-oxopropanoic acid
(1R)-1-(3,5-dimethoxyphenyl)-1-hydroxypropan-2-one + CO2
-
-
-
-
?
3-(4-hydroxyphenyl)-2-oxopropanoic acid
(4-hydroxyphenyl)-acetaldehyde + CO2
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at 30 mM 6% activity relative to 3-methyl-2-oxobutanoic acid
-
-
?
3-formylbenzonitrile + 2-oxobutanoic acid
3-[(1R)-1-hydroxy-2-oxobutyl]benzonitrile
-
-
-
-
?
4-(4-hydroxyphenyl)-2-oxobutanoic acid
3-(4-hydroxyphenyl)-propanal + CO2
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at 30 mM 1.6% activity relative to 3-methyl-2-oxobutanoic acid
-
-
?
4-(methylsulfanyl)-2-oxobutanoic acid
3-(methylsulfanyl)-propanal + CO2
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at 30 mM 18% activity relative to 3-methyl-2-oxobutanoic acid
-
-
?
4-methyl-2-oxohexanoic acid
3-methylpentanal + CO2
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at 30 mM 19% activity relative to 3-methyl-2-oxobutanoic acid
-
-
?
4-methylthio-2-oxobutanoic acid
3-methylthiopropanal + CO2
10% of the rate with 3-methyl-2-oxobutanoic acid
-
-
?
5-(4-hydroxyphenyl)-2-oxopentanoic acid
4-(4-hydroxyphenyl)-butanal + CO2
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at 30 mM 1.1% activity relative to 3-methyl-2-oxobutanoic acid
-
-
?
indole-3-pyruvate
?
-
at 1 mM 0.85% activity relative to 3-methyl-2-oxobutanoic acid
-
-
?
oxo(phenyl)acetic acid
benzaldehyde + CO2
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at 30 mM 8.4% activity relative to 3-methyl-2-oxobutanoic acid
-
-
?
(indol-3-yl)pyruvate
(indol-3-yl)acetaldehyde + CO2
-
-
-
?
(indol-3-yl)pyruvate
(indol-3-yl)acetaldehyde + CO2
-
-
-
?
2-oxobutanoic acid
propanal + CO2
10% of the rate with 3-methyl-2-oxobutanoic acid
-
-
?
2-oxobutanoic acid
propanal + CO2
-
at 30 mM 9.3% activity relative to 3-methyl-2-oxobutanoic acid
-
-
?
2-oxohexanoic acid
pentanal + CO2
30% of the rate with 3-methyl-2-oxobutanoic acid
-
-
?
2-oxohexanoic acid
pentanal + CO2
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at 30 mM 13% activity relative to 3-methyl-2-oxobutanoic acid
-
-
?
2-oxoisocaproate
3-methylbutanal + CO2
22.7% of the activity with 2-oxoisovalerate
-
-
?
2-oxoisohexanoate
CO2 + isopentanal
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38% of the activity with L-3-methyl-2-oxopentanoate
-
-
?
2-oxoisohexanoate
CO2 + isopentanal
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38% of the activity with L-3-methyl-2-oxopentanoate
-
-
?
2-oxomethylvalerate
pentanal + CO2
16.7% of the activity with 2-oxoisovalerate
-
-
?
2-oxopentanoic acid
butanal + CO2
25% of the rate with 3-methyl-2-oxobutanoic acid
-
-
?
2-oxopentanoic acid
butanal + CO2
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at 30 mM 15% activity relative to 3-methyl-2-oxobutanoic acid
-
-
?
3-methyl-2-oxopentanoic acid
2-methylbutanal + CO2
30% of the rate with 3-methyl-2-oxobutanoic acid
-
-
?
3-methyl-2-oxopentanoic acid
2-methylbutanal + CO2
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at 30 mM 38.1% activity relative to 3-methyl-2-oxobutanoic acid
-
-
?
4-hydroxyphenylpyruvate
4-hydroxyphenylacetaldehyde + CO2
-
-
-
?
4-hydroxyphenylpyruvate
4-hydroxyphenylacetaldehyde + CO2
-
-
-
?
4-methyl-2-oxopentanoic acid
3-methylbutanal + CO2
35% of the rate with 3-methyl-2-oxobutanoic acid
-
-
?
4-methyl-2-oxopentanoic acid
3-methylbutanal + CO2
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at 30 mM 26.3% activity relative to 3-methyl-2-oxobutanoic acid
-
-
?
4-methylthio-2-oxobutanoate
3-methylthiopropanal + CO2
-
-
-
?
L-3-methyl-2-oxopentanoate
CO2 + 2-methylbutanal
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stereospecificity towards the L-isomer
-
-
?
Phenylpyruvate
Phenylacetaldehyde + CO2
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8.8% of the activity with 2-oxoisovalerate
-
?
pyruvate
ethanal + CO2
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25% of the activity with L-3-methyl-2-oxopentanoate
-
-
?
additional information
?
-
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essential for the synthesis of branched-chain fatty acids
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-
?
additional information
?
-
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plants with enzymic activity show enhanced cold tolerance, role as a protective mechanism for growth of plants under sub optimal temperatures
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-
?
additional information
?
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acetolactate synthase AlsS, EC 2.2.1.6, is able to catalyze the decarboxylation of 2-oxoisovalerate both in vivo and in vitro
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-
?
additional information
?
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acetolactate synthase AlsS, EC 2.2.1.6, is able to catalyze the decarboxylation of 2-oxoisovalerate both in vivo and in vitro
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-
?
additional information
?
-
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3-fluoro-2-oxopropanoic acid, isobutyraldehyde, 3,5-dichlorobenzaldehyde, 3,5-dimethoxybenzaldehyde and 2-oxooctanoic acid are no substrates
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-
?
additional information
?
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the enzyme is also able to catalyze carboligation reactions with an exceptionally broad substrate range, a feature that makes KdcA a potentially valuable biocatalyst for C-C bond formation, in particular for the enzymatic synthesis of diversely substituted 2-hydroxyketones with high enantioselectivity
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-
?
additional information
?
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enzyme additionallly catalyzes the asymmetric synthesis of chiral 2-hydroxy ketones with high stereochemical purity
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-
?
additional information
?
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very poor substrates: indole-3-pyruvate and pyruvate
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-
?
additional information
?
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enzyme is found to convert a broad spectrum of branched-chain and aromatic alpha-keto acids. Determined the catalytic constants for the conversion of 11 aliphatic, aromatic, and branched-chain alpha-keto acids
-
-
?
additional information
?
-
-
enzyme is found to convert a broad spectrum of branched-chain and aromatic alpha-keto acids. Determined the catalytic constants for the conversion of 11 aliphatic, aromatic, and branched-chain alpha-keto acids
-
-
?
additional information
?
-
enzyme is found to convert a broad spectrum of branched-chain and aromatic alpha-keto acids. Determined the catalytic constants for the conversion of 11 aliphatic, aromatic, and branched-chain alpha-keto acids
-
-
?
additional information
?
-
-
enzyme is found to convert a broad spectrum of branched-chain and aromatic alpha-keto acids. Determined the catalytic constants for the conversion of 11 aliphatic, aromatic, and branched-chain alpha-keto acids
-
-
?
additional information
?
-
-
mitochondrial branched-chain aminotransferase binds to the E1 decarboxylase of BCKDC, forming a metabolon that allows channeling of branched-chain alpha-keto acids from mitochondrial branched-chain aminotransferase to E1
-
-
?
