4.1.1.72: branched-chain-2-oxoacid decarboxylase

This is an abbreviated version!
For detailed information about branched-chain-2-oxoacid decarboxylase, go to the full flat file.

Reaction

Synonyms

alpha-keto acid decarboxylase, AlsS, BCKA, BCKAD, BCKDC, branched-chain 2-keto acid decarboxylase, branched-chain 2-oxoacid decarboxylase, branched-chain alpha-keto acid decarboxylase, branched-chain alpha-ketoacid dehydrogenase complex, branched-chain keto acid decarboxylase, branched-chain oxo acid decarboxylase, decarboxylase, branched-chain oxo acid, KDC, KdcA, MtKDC, THI3, thiamine metabolism regulatory protein, YDL080c

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.72 branched-chain-2-oxoacid decarboxylase

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Results	in table
3	Activating Compound
88	AA Sequence
9	Application
1	CAS Registry Number
9	Cloned(Commentary)
8	Cofactor
1	Crystallization (Commentary)
43	Disease/ Diagnostics
3	General Information
9	Inhibitors
10	kcat/KM [mM/s]
1	Ki Value [mM]
68	KM Value [mM]
3	Localization
6	Metals/Ions
24	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
39	Organism
8	Pathway
7	pH Optimum
4	pH Range
3	pH Stability
1	Posttranslational Modification
36	Protein Variants
9	Purification (Commentary)
2	Reaction
1	Reaction Type
35	Reference
2	Renatured (Commentary)
3	Source Tissue
2	Specific Activity [micromol/min/mg]
116	Substrates and Products (Substrate)
18	Subunits
40	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
9	Temperature Stability [°C]
58	Turnover Number [1/s]

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Turnover Number on EC 4.1.1.72 - branched-chain-2-oxoacid decarboxylase

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2.98

(indol-3-yl)pyruvate

Mycobacterium tuberculosis

P9WG37

-

693210

19.75

2-oxo-3-methylpentanoate

Mycobacterium tuberculosis

P9WG37

-

693210

5.98

2-oxobutyrate

Mycobacterium tuberculosis

P9WG37

-

693210

7.06

2-Oxohexanoate

Mycobacterium tuberculosis

P9WG37

-

693210

31.5

2-Oxoisohexanoate

Mycobacterium tuberculosis

P9WG37

-

693210

28.35

2-oxoisopentanoate

Mycobacterium tuberculosis

P9WG37

-

693210

0.19 - 8.9

2-oxoisovalerate

16 entries

6.95

2-oxopentanoate

Mycobacterium tuberculosis

P9WG37

-

693210

0.3 - 149

3-methyl-2-oxobutanoate

9 entries

29 - 33

3-methyl-2-oxobutyrate

2 entries

0.5 - 27

3-methyl-2-oxopentanoate

4 entries

3.89

4-hydroxyphenylpyruvate

Mycobacterium tuberculosis

P9WG37

-

693210

0.17 - 8.5

4-methyl-2-oxopentanoate

3 entries

18.57

benzoylformate

Mycobacterium tuberculosis

P9WG37

-

693210

1.7 - 7.5

phenylpyruvate

3 entries

0.09 - 2.14

pyruvate

2 entries

0.19 - 0.53

thiamine diphosphate

10 entries

0.19

2-oxoisovalerate

Homo sapiens

-

wild-type, pH 7.5, 30°C, E1b-catalyzed decarboxylation reaction

656230

0.19

2-oxoisovalerate

Homo sapiens

-

wild-type, pH 7.5, 30°C, overall reaction

656230

0.38

2-oxoisovalerate

Homo sapiens

-

mutant Y300A, pH 7.5, 30°C, E1b-catalyzed decarboxylation reaction

656230

0.38

2-oxoisovalerate

Homo sapiens

-

mutant Y300A, pH 7.5, 30°C, overall reaction

656230

0.41

2-oxoisovalerate

Homo sapiens

-

mutant R301A, pH 7.5, 30°C, E1b-catalyzed decarboxylation reaction

656230

0.41

2-oxoisovalerate

Homo sapiens

-

mutant R301A, pH 7.5, 30°C, overall reaction

656230

0.48

2-oxoisovalerate

Homo sapiens

-

mutant D295A, pH 7.5, 30°C, E1b-catalyzed decarboxylation reaction

656230

0.48

2-oxoisovalerate

Homo sapiens

-

mutant D295A, pH 7.5, 30°C, overall reaction

656230

0.57

2-oxoisovalerate

Homo sapiens

-

mutant Y300F, pH 7.5, 30°C, E1b-catalyzed decarboxylation reaction

656230

0.57

2-oxoisovalerate

Homo sapiens

-

mutant Y300F, pH 7.5, 30°C, overall reaction

656230

0.8

2-oxoisovalerate

Bacillus subtilis

Q04789

mutant Q487G, pH 7.0, 37°C

695784

0.8

2-oxoisovalerate

Bacillus subtilis

Q04789

mutant Q487S, pH 7.0, 37°C

695784

1.1

2-oxoisovalerate

Bacillus subtilis

Q04789

mutant Q487A, pH 7.0, 37°C

695784

4.8

2-oxoisovalerate

Bacillus subtilis

Q04789

mutant Q487I, pH 7.0, 37°C

695784

5.4

2-oxoisovalerate

Bacillus subtilis

Q04789

mutant Q487L, pH 7.0, 37°C

695784

8.9

2-oxoisovalerate

Bacillus subtilis

Q04789

wild-type, pH 7.0, 37°C

695784

0.3

3-methyl-2-oxobutanoate

Thermoplasma acidophilum

Q9HIA4; Q9HIA3

pH 7.0, 55°C

747761

5.2

3-methyl-2-oxobutanoate

Lactococcus lactis

Q6QBS4

mutant V461I/A290M/Q252N/D306G/E316R/F388Y/I404C, pH 6.5, 30°C

747587

43

3-methyl-2-oxobutanoate

Lactococcus lactis

Q6QBS4

mutant V461I/A290M/Q252N/D306G/E316R/F388Y/L434C/M290V, pH 6.5, 30°C

747587

69

3-methyl-2-oxobutanoate

Lactococcus lactis

Q6QBS4

mutant V461I/A290M/Q252N/D306G/E316R/F388Y/L434C/M290C, pH 6.5, 30°C

747587

95

3-methyl-2-oxobutanoate

Lactococcus lactis

Q6QBS4

mutant A290M/Q252N/D306G/E316R/F388Y/L434C, pH 6.5, 30°C

747587

118

3-methyl-2-oxobutanoate

Lactococcus lactis

Q6QBS4

mutant V461I/A290M, pH 6.5, 30°C

747587

120

3-methyl-2-oxobutanoate

Lactococcus lactis

Q6QBS4

mutant V461I, pH 6.5, 30°C

747587

145

3-methyl-2-oxobutanoate

Lactococcus lactis

Q6QBS4

wild-type, pH 6.5, 30°C

747587

149

3-methyl-2-oxobutanoate

Lactococcus lactis

Q6QBS4

mutant V461I/A290M/Q252N/D306G/E316R/F388Y, pH 6.5, 30°C

747587

29

3-methyl-2-oxobutyrate

Psychrobacter arcticus

-

pH and temperature not specified in the publication

727556

33

3-methyl-2-oxobutyrate

Psychrobacter cryohalolentis

-

pH and temperature not specified in the publication

727556

0.5

3-methyl-2-oxopentanoate

Thermoplasma acidophilum

Q9HIA4; Q9HIA3

pH 7.0, 55°C

747761

23

3-methyl-2-oxopentanoate

Psychrobacter arcticus

-

pH and temperature not specified in the publication

727556

25

3-methyl-2-oxopentanoate

Lactococcus lactis

-

pH and temperature not specified in the publication

727556

27

3-methyl-2-oxopentanoate

Psychrobacter cryohalolentis

-

pH and temperature not specified in the publication

727556

0.17

4-methyl-2-oxopentanoate

Thermoplasma acidophilum

Q9HIA4; Q9HIA3

pH 7.0, 55°C

747761

7

4-methyl-2-oxopentanoate

Psychrobacter arcticus

-

pH and temperature not specified in the publication

727556

8.5

4-methyl-2-oxopentanoate

Psychrobacter cryohalolentis

-

pH and temperature not specified in the publication

727556

1.7

phenylpyruvate

Psychrobacter arcticus

-

pH and temperature not specified in the publication

727556

1.8

phenylpyruvate

Psychrobacter cryohalolentis

-

pH and temperature not specified in the publication

727556

7.5

phenylpyruvate

Mycobacterium tuberculosis

P9WG37

-

693210

0.09

pyruvate

Thermoplasma acidophilum

Q9HIA4; Q9HIA3

pH 7.0, 55°C

747761

2.14

pyruvate

Mycobacterium tuberculosis

P9WG37

-

693210

0.19

thiamine diphosphate

Homo sapiens

-

wild-type, pH 7.5, 30°C, E1b-catalyzed decarboxylation reaction

656230

0.19

thiamine diphosphate

Homo sapiens

-

wild-type, pH 7.5, 30°C, overall reaction

656230

0.31

thiamine diphosphate

Homo sapiens

-

mutant Y300A, pH 7.5, 30°C, E1b-catalyzed decarboxylation reaction

656230

0.31

thiamine diphosphate

Homo sapiens

-

mutant Y300A, pH 7.5, 30°C, overall reaction

656230

0.41

thiamine diphosphate

Homo sapiens

-

mutant R301A, pH 7.5, 30°C, E1b-catalyzed decarboxylation reaction

656230

0.41

thiamine diphosphate

Homo sapiens

-

mutant R301A, pH 7.5, 30°C, overall reaction

656230

0.42

thiamine diphosphate

Homo sapiens

-

mutant D295A, pH 7.5, 30°C, E1b-catalyzed decarboxylation reaction

656230

0.42

thiamine diphosphate

Homo sapiens

-

mutant D295A, pH 7.5, 30°C, overall reaction

656230

0.53

thiamine diphosphate

Homo sapiens

-

mutant Y300F, pH 7.5, 30°C, E1b-catalyzed decarboxylation reaction

656230

0.53

thiamine diphosphate

Homo sapiens

-

mutant Y300F, pH 7.5, 30°C, overall reaction

656230