3.5.1.61: mimosinase
This is an abbreviated version!
For detailed information about mimosinase, go to the full flat file.
Word Map on EC 3.5.1.61
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3.5.1.61
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leucaena
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mimosa
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leucocephala
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non-protein
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3-hydroxy-4-pyridone
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nutrition
- 3.5.1.61
- leucaena
- mimosa
- leucocephala
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non-protein
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3-hydroxy-4-pyridone
- nutrition
Reaction
Synonyms
mimosine degrading enzyme, mimosine-degrading enzyme, Mp mimosinase
ECTree
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Substrates Products
Substrates Products on EC 3.5.1.61 - mimosinase
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REACTION DIAGRAM
(S)-2-amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate + H2O
3-hydroxy-4(1H)-pyrid-4-one + L-serine
(S)-2-amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate + H2O
3-hydroxy-4H-pyrid-4-one + pyruvate + NH3
beta-[N-(3-hydroxy-4(1H)-pyridone)]-alpha-aminopropionic acid + H2O
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3-hydroxy-4(1H)-pyrid-4-one + L-serine
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free toxic amino acid mimosine, 3-(3-hydroxy-4-oxo-1(4H)-pyridyl)-L-alanine, beta-[N-(3-hydroxy-4(1H)-pyridone)]-alpha-aminopropionic acid, beta-[N-(3-hydroxy-4-oxypyridyl)]-alpha-aminopropionic acid
DHP, less toxic than mimosine
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(S)-2-amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate + H2O
3-hydroxy-4(1H)-pyrid-4-one + L-serine
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free toxic amino acid mimosine, 3-(3-hydroxy-4-oxo-1(4H)-pyridyl)-L-alanine, beta-[N-(3-hydroxy-4(1H)-pyridone)]-alpha-aminopropionic acid, beta-[N-(3-hydroxy-4-oxypyridyl)]-alpha-aminopropionic acid
DHP, less toxic than mimosine
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3-hydroxy-4H-pyrid-4-one + pyruvate + NH3
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(S)-2-amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate + H2O
3-hydroxy-4H-pyrid-4-one + pyruvate + NH3
i.e. mimosine, a toxic nonprotein aromatic amino acid. Dependence of the enzyme on pyridoxal 5'-phosphate and the production of 3-hydroxy-4H-pyrid-4-one with the release of ammonia indicate that the enzyme is a carbon-nitrogen lyase
product identification by by electrospray ionization-tandem mass spectrometry
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3-hydroxy-4-(1H)-pyridone + pyruvate + NH3
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substrate docking study. Cystathionine is a larger molecule than mimosine and consists of propyl (C3) and ethyl (C2) chains bound by a thioether linkage. The ethyl chain moiety and PLP of the complex interacts with Arg417, Lys255, Arg105', and Gly133 as is the case for mimosine
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additional information
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substrate docking study. Cystathionine is a larger molecule than mimosine and consists of propyl (C3) and ethyl (C2) chains bound by a thioether linkage. The ethyl chain moiety and PLP of the complex interacts with Arg417, Lys255, Arg105', and Gly133 as is the case for mimosine
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