3.5.1.61: mimosinase

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For detailed information about mimosinase, go to the full flat file.

Reaction

Synonyms

mimosine degrading enzyme, mimosine-degrading enzyme, Mp mimosinase

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.61 mimosinase

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Results	in table
3	AA Sequence
1	Application
1	CAS Registry Number
3	Cloned(Commentary)
4	Cofactor
5	General Information
7	Inhibitors
2	kcat/KM [mM/s]
4	KM Value [mM]
4	Localization
2	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
5	Organism
5	pH Optimum
2	pH Range
2	Purification (Commentary)
1	Reaction
1	Reaction Type
5	Reference
8	Source Tissue
9	Substrates and Products (Substrate)
1	Subunits
3	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
2	Temperature Range [°C]
4	Temperature Stability [°C]
2	Turnover Number [1/s]

General Information

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General Information on EC 3.5.1.61 - mimosinase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Mimosa pudica

U6BYK3

mutational analysis of Mp mimosinase reveals that the disruption of a disulfide bond in the vicinity of the pyridoxal 5'-phosphate domain increases the enzyme's preference toward cystathionine

754484

metabolism

2 entries

physiological function

Leucaena leucocephala

A8CEI3

mimosinase is an important enzyme especially in the context of metabolic engineering of plant secondary metabolite as it catalyzes the degradation of mimosine, which is a toxic secondary metabolite found in all Leucaena and Mimosa species

754627

additional information

2 entries

metabolism

Leucaena leucocephala

A8CEI3

the carbon-nitrogen lyase catalyzes the first step of mimosine degradation. Mimosine is a toxic nonprotein aromatic amino acid

734969

metabolism

Mimosa pudica

U6BYK3

molecular relationship between mimosinase and cystathionine beta-lyase (CBL, UniProt ID A0A0M3VI47, EC 4.4.1.13). The recombinant Mp mimosinase degrades both mimosine and cystathionine with a much higher turnover number for mimosine compared with cystathionine, and Mp CBL utilizes only cystathionine as a substrate

754484

additional information

Mimosa pudica

U6BYK3

homology modeling and molecular dynamics simulations of Mp mimosinase suggest a closer coordination of the residues that interact with mimosine at the active site compared with cystathionine, indicating a more compact pocket size for mimosine degradation, substrate docking study. Active site structure

754484

additional information

Mimosa pudica

-

homology modeling and molecular dynamics simulations of Mp mimosinase suggest a closer coordination of the residues that interact with mimosine at the active site compared with cystathionine, indicating a more compact pocket size for mimosine degradation, substrate docking study. Active site structure

754484