3.5.1.38: glutamin-(asparagin-)ase
This is an abbreviated version!
For detailed information about glutamin-(asparagin-)ase, go to the full flat file.
Word Map on EC 3.5.1.38
Reaction
Synonyms
asparaginase A, asparaginase B, glutaminase-asparaginase, glutaminase/asparaginase, periplasmic glutaminase/asparaginase, PGA
ECTree
3.5.1.38 glutamin-(asparagin-)aseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.5.1.38 - glutamin-(asparagin-)ase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
N-carbamoyl-L-asparagine + H2O
N-carbamoyl-L-aspartate + NH3
-
-
-
?
N-glycyl-L-asparagine + H2O
N-glycyl-L-aspartate + NH3
-
60% higher activity than on L-asparagine
-
?
beta-D-aspartyl hydroxylammonium sulfate + H2O
L-Asp + hydroxylammonium sulfate
-
only asparaginase A, low activity
-
?
beta-D-aspartyl hydroxylammonium sulfate + H2O
L-Asp + hydroxylammonium sulfate
-
-
-
?
beta-L-aspartyl hydroxylammonium sulfate + H2O
L-Asp + hydroxylammonium sulfate
-
higher activity for asparaginase B
-
?
beta-L-aspartyl hydroxylammonium sulfate + H2O
L-Asp + hydroxylammonium sulfate
-
-
-
?
beta-L-aspartyl hydroxylammonium sulfate + H2O
L-Asp + hydroxylammonium sulfate
-
-
-
?
beta-L-aspartyl hydroxylammonium sulfate + H2O
L-Asp + hydroxylammonium sulfate
-
-
-
?
D-asparagine + H2O
D-aspartate + NH3
-
one third of the L-isomer
-
?
gamma-L-glutamyl hydroxylammonium sulfate + H2O
L-glutamate + hydroxylammonium sulfate
-
-
-
?
gamma-L-glutamyl hydroxylammonium sulfate + H2O
L-glutamate + hydroxylammonium sulfate
-
very low activities for both asparaginases A and B
-
?
gamma-L-glutamyl hydroxylammonium sulfate + H2O
L-glutamate + hydroxylammonium sulfate
-
-
-
?
gamma-L-glutamyl hydroxylammonium sulfate + H2O
L-glutamate + hydroxylammonium sulfate
-
same rate as for L-glutamine
-
?
gamma-L-glutamyl hydroxylammonium sulfate + H2O
L-glutamate + hydroxylammonium sulfate
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
involved in the maintenance of the correct L-asparagine/L-aspartate ratio
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
ratio of glutaminase to aspariginase activity is 0.7 to 1
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
involved in the maintenance of the correct L-asparagine/L-aspartate ratio
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
hydrolysed at a rate of 0.83 compared to L-glutamine
-
?
L-asparagine + H2O
L-aspartate + NH3
-
involved in the maintenance of the correct L-asparagine/L-aspartate ratio
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
ratio of glutaminase to aspariginase activity is 1.4 to 1
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
involved in the maintenance of the correct L-asparagine/L-aspartate ratio
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
ratio of glutaminase to aspariginase activity is 0.8 to 1
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
hydrolysed at a rate of 0.73 compared to L-glutamine
-
?
L-asparagine + H2O
L-aspartate + NH3
-
hydrolysis at a rate of 0.73 compared to L-glutamine
-
?
L-asparagine + H2O
L-aspartate + NH3
-
hydrolysed at a rate of 0.73 compared to L-glutamine
-
?
L-asparagine + H2O
L-aspartate + NH3
-
hydrolysis at a rate of 0.73 compared to L-glutamine
-
?
L-asparagine + H2O
L-aspartate + NH3
-
not active on D-asparagine
-
?
L-glutamine + H2O
L-glutamate + NH3
-
higher activity for glutaminase than for asparaginase
-
?
L-glutamine + H2O
L-glutamate + NH3
-
involved in the maintenance of the correct L-glutamine/L-glutamate ratio
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
ratio of glutaminase to aspariginase activity is 0.7 to 1
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
involved in the maintenance of the correct L-glutamine/L-glutamate ratio
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
ratio of glutaminase to aspariginase activity is 0.7 to 1
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
involved in the maintenance of the correct L-glutamine/L-glutamate ratio
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
ratio of glutaminase to aspariginase activity is 1.4 to 1
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
involved in the maintenance of the correct L-glutamine/L-glutamate ratio
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
ratio of glutaminase to aspariginase activity is 0.8 to 1
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
higher activity for glutaminase than for asparaginase
-
?
L-glutamine + H2O
L-glutamate + NH3
-
higher activity for glutaminase than for asparaginase
-
?
L-glutamine + H2O
L-glutamate + NH3
-
higher activity for glutaminase than for asparaginase
-
?
L-glutamine + H2O
L-glutamate + NH3
-
higher activity for glutaminase than for asparaginase
-
?
L-glutamine + H2O
L-glutamate + NH3
-
one fifth of the activity on L-asparagine
-
?
L-glutamine + H2O
L-glutamate + NH3
Tilachlidium humicola
-
lower activity than for L-asparagine
-
?
N-acetyl-L-asparagine + H2O
N-acetyl-L-aspartate + NH3
-
5% of the activity compared to L-asparagine
-
?
additional information
?
-
-
acetamide, nicotinamide, and NAD are not hydrolyzed
-
-
?
additional information
?
-
-
acetamide, nicotinamide, and NAD are not hydrolyzed
-
-
?
additional information
?
-
-
acetamide, nicotinamide, and NAD are not hydrolyzed
-
-
?
additional information
?
-
-
acetamide, nicotinamide, and NAD are not hydrolyzed
-
-
?
additional information
?
-
-
glutaminase/asparaginase is downregulated during growth of the aauR mutant on Glu
-
-
?
additional information
?
-
-
glutaminase/asparaginase is downregulated during growth of the aauR mutant on Glu
-
-
?
