3.5.1.38: glutamin-(asparagin-)ase
This is an abbreviated version!
For detailed information about glutamin-(asparagin-)ase, go to the full flat file.
Word Map on EC 3.5.1.38
Reaction
Synonyms
asparaginase A, asparaginase B, glutaminase-asparaginase, glutaminase/asparaginase, periplasmic glutaminase/asparaginase, PGA
ECTree
3.5.1.38 glutamin-(asparagin-)aseAdvanced search results
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results (Inhibitors
Inhibitors on EC 3.5.1.38 - glutamin-(asparagin-)ase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
2-Hydroxy-5-nitrobenzyl bromide
-
40% inhibition at 10 mM, concentration-dependent, protection against inhibition in presence of substrate
aspartic acid
-
competitive inhibition, Ki: glutaminase activity 0.16 mM, asparaginase activity 0.53 mM
azaserine
-
competitive not reversible inhibition of both activities
D-asparagine
Tilachlidium humicola
-
mixed type of competitive and non-competitive inhibition, Ki: 7.2-8.4 mM
glutamic acid
-
competitive inhibition, Ki: glutaminase acitvity 5 mM, asparaginase activity 3 mM
L-asparagine
-
competitive inhibition of glutaminase activity, Ki: 0.02 mM
N-bromosuccinimide
-
concentration-dependent inhibition, 40% at 10 mM, protection against inhibition in presence of substrate
NH4Cl
-
weak non-competitive inhibition of glutaminase activity
5-Diazo-4-oxo-L-norvaline
inactivation by covalent binding to Thr20 and Tyr34
6-diazo-5-oxo-L-norleucine
-
irreversible inhibition at very low concentrations
6-diazo-5-oxo-L-norleucine
-
competitive not reversible inhibition of both activities after extensive dialysis
6-diazo-5-oxo-L-norleucine
inactivation by covalent binding to Thr20 and Tyr34
p-chloromercuribenzoate
-
complete inhibition at 0.1 mM, asparaginases A and B
