3.5.1.38: glutamin-(asparagin-)ase

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Word Map on EC 3.5.1.38

3.5.1.38

leukemia

lymphoblastic

l-asparaginase

succinylated

erwinia

6-diazo-5-oxo-l-norleucine

drug development

medicine

Reaction

Synonyms

asparaginase A, asparaginase B, glutaminase-asparaginase, glutaminase/asparaginase, periplasmic glutaminase/asparaginase, PGA

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.1.38 glutamin-(asparagin-)ase

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Results	in table
4	Activating Compound
288	AA Sequence
3	Application
1	CAS Registry Number
2	Cloned(Commentary)
4	Crystallization (Commentary)
2	General Stability
36	Inhibitors
3	Ki Value [mM]
25	KM Value [mM]
8	Localization
2	Metals/Ions
10	Molecular Weight [Da]
52	Natural Substrates/ Products (Substrates)
170	Organism
18	Pathway
34	PDB ID
4	pH Optimum
5	pH Range
3	pH Stability
2	Protein Variants
12	Purification (Commentary)
1	Reaction
1	Reaction Type
30	Reference
19	Source Tissue
13	Specific Activity [micromol/min/mg]
4	Storage Stability
117	Substrates and Products (Substrate)
13	Subunits
11	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Range [°C]
8	Temperature Stability [°C]
3	Turnover Number [1/s]

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drug development

2 entries

medicine

Streptomyces canarius

L-glutaminase has a significant efficiency against Hep-G2 cell (IC50 6.8x02g/ml) and HeLa cells (IC50 8.3 g/ml), while the growth of MCF-7 cells is not affected. L-glutaminase has a moderate cytotoxic effect against HCT-116 cells (IC50 64.7 g/ml) and RAW 264.7 cells (IC50 59.3 g/ml). In vivo, L-glutaminase shows no observed changes in liver, kidney functions, hematological parameters and slight effect on red blood cells and level of platelets after 10 days of rabbit's injection

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