3.5.1.104: peptidoglycan-N-acetylglucosamine deacetylase
This is an abbreviated version!
For detailed information about peptidoglycan-N-acetylglucosamine deacetylase, go to the full flat file.
Word Map on EC 3.5.1.104
-
3.5.1.104
-
lysozyme
-
deacetylation
-
streptococcus
-
pylori
-
helicobacter
-
chitin
-
cereus
-
listeria
-
monocytogenes
-
anthracis
-
muropeptides
-
lysozyme-induced
-
chitooligosaccharides
-
autolysins
-
de-n-acetylation
-
n-acetylmuramic
-
pharmacology
-
medicine
- 3.5.1.104
- lysozyme
-
deacetylation
- streptococcus
- pylori
- helicobacter
- chitin
- cereus
- listeria
- monocytogenes
- anthracis
- muropeptides
-
lysozyme-induced
- chitooligosaccharides
- autolysins
-
de-n-acetylation
-
n-acetylmuramic
- pharmacology
- medicine
Reaction
Synonyms
BA1961, BA1977, BA2944, BC1960, Bc1974, BC3618, BC_1960, BC_1974, enzyme BC1960, enzyme BC3618, GlcNAc deacetylase, HP0310, HP310, HpPgdA, Lmo0415, MurNAc deacetylase, N-acetylglucosamine deacetylase, N-acetylglucosamine deacetylase BC1960, PdaC, peptidoglycan deacetlyase, peptidoglycan deacetylase, peptidoglycan GlcNAc deacetylase, peptidoglycan GlcNAc deacetylases, peptidoglycan N-acetylglucosamine deacetylase, peptidoglycan N-acetylglucosamine deacetylase BC1960, PG N-deacetylase, Pgd, pgdA, pgdA_1, pgdA_2, PGNG-dac, PGNGdacs, polysaccharide deacetylase, polysaccharide deacetylase C, Rv1096 protein, SfPgdA, SpPgdA, yheN, YjeA
ECTree
3.5.1.104 peptidoglycan-N-acetylglucosamine deacetylaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.5.1.104 - peptidoglycan-N-acetylglucosamine deacetylase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-methylumbelliferyl acetate + H2O
4-methylumbelliferol + acetate
-
-
-
-
?
GlcNAc-beta-1,4-GlcNAc + H2O
?
-
no deacetylation of the reducing GlcNAc residue
-
-
?
GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc + H2O
?
-
deacetylates all GlcNAc residues of the oligomer except the reducing end ones
-
-
?
GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc + H2O
GlcNAc-beta-1,4-GlcN-beta-1,4-GlcNAc + acetate
-
-
-
?
GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc + H2O
?
-
GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc is the favorable substrate. Deacetylates all GlcNAc residues of the oligomer except the reducing end ones
-
-
?
GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc + H2O
GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcN-beta-1,4-GlcNAc + acetate
GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc + H2O
?
-
deacetylates all GlcNAc residues of the oligomer except the reducing end ones
-
-
?
GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc + H2O
?
-
deacetylates all GlcNAc residues of the oligomer except the reducing end ones
-
-
?
GlcNAcbeta(1-4)GlcNAcbeta(1-4)GlcNAcbeta(1-4)GlcNAcbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O
GlcNbeta(1-4)GlcNbeta(1-4)GlcNbeta(1-4)GlcNbeta(1-4)GlcNbeta(1-4)GlcNAc
-
-
-
?
N,N',N'',N''',N''''-pentaacetylchitopentaose + H2O
N,N',N''-triacetylchitopentaose + N,N'-diacetylchitopentaose + N-acetylchitopentaose + acetate
-
-
almost quantitative conversion to mono-, di- and tri-de-acetylated products
-
?
peptidoglycan from Streptococcus suis + H2O
deacetylated peptidoglycan + acetate
-
-
-
-
?
peptidoglycan from wild-type Streptococcus pneumoniae + H2O
deacetylated peptidoglycan + acetate
-
-
-
-
?
acetylated peptidoglycan + H2O
deacetylated peptidoglycan + acetate
-
-
-
-
?
acetylated peptidoglycan + H2O
deacetylated peptidoglycan + acetate
-
enzymatic deacetylation of chemically acetylated vegetative peptidoglycan from Bacillus cereus by BC1960 and BC3618 results in increased resistance to lysozyme digestion
-
-
?
acetylated peptidoglycan + H2O
deacetylated peptidoglycan + acetate
-
effective in deacetylating cell wall peptidoglycan from the Gram(+) Bacillus cereus and Bacillus subtilis and the Gram(-) Helicobacter pylori
-
-
?
acetylated peptidoglycan + H2O
deacetylated peptidoglycan + acetate
-
-
-
-
?
acetylated peptidoglycan + H2O
deacetylated peptidoglycan + acetate
-
enzymic N-acetylglucosamine deacetylation protects peptidoglycan from hydrolysis by the major autolysin AcmA in Lactococcus lactis cells, and this leads to decreased cellular autolysis
-
-
?
acetylated peptidoglycan + H2O
deacetylated peptidoglycan + acetate
-
-
-
-
?
acetylated peptidoglycan + H2O
deacetylated peptidoglycan + acetate
-
enzymic N-acetylglucosamine deacetylation protects peptidoglycan from hydrolysis by the major autolysin AcmA in Lactococcus lactis cells, and this leads to decreased cellular autolysis
-
-
?
acetylated peptidoglycan + H2O
deacetylated peptidoglycan + acetate
-
-
-
-
?
acetylated peptidoglycan + H2O
deacetylated peptidoglycan + acetate
-
N-deacetylation is a major modification of Listeria peptidoglycan. PG N-deacetylation could be a general mechanism used by bacteria to evade the host innate immune system
-
-
?
acetylated peptidoglycan + H2O
deacetylated peptidoglycan + acetate
-
-
-
-
?
acetylated peptidoglycan + H2O
deacetylated peptidoglycan + acetate
-
-
-
?
acetylated peptidoglycan + H2O
deacetylated peptidoglycan + acetate
-
-
-
?
acetylated peptidoglycan + H2O
deacetylated peptidoglycan + acetate
peptidoglycan GlcNAc deacetylase protects the Gram-positive bacterial cell wall from host lysozymes by deacetylating peptidoglycan GlcNAc residues
-
-
?
acetylated peptidoglycan + H2O
deacetylated peptidoglycan + acetate
contribution of lysozyme and peptidoglycan modifications during colonization of the upper respiratory tract analyzed
-
-
?
GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc + H2O
GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcN-beta-1,4-GlcNAc + acetate
-
deacetylation of the chitin oligomer at position 3
-
-
?
GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcNAc + H2O
GlcNAc-beta-1,4-GlcNAc-beta-1,4-GlcN-beta-1,4-GlcNAc + acetate
-
deacetylation of the chitin oligomer at position 3
-
-
?
GlcNAc-Mur[-L-Ala-D-Glu]-GlcNAc-MurNAcr[-L-Ala-D-Glu] + H2O
?
-
i.e. 4S2P, deacetylation
-
-
?
GlcNAc-Mur[-L-Ala-D-Glu]-GlcNAc-MurNAcr[-L-Ala-D-Glu] + H2O
?
-
i.e. 4S2P, deacetylation
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
Q81P72, Q81RR3
-
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
Q81P72, Q81RR3
-
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
-
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
-
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
-
substrates: peptidoglycans digested by DL-endopeptidase, or by LD-endopeptidase, or by L-alanine amidase, the latter is a very poor substrate. Purified recombinant and truncated enzyme, expressed in Escherichia coli, deacetylates Bacillus subtilis peptidoglycan and its polymer, (-GlcNAc-MurNAc[-L-Ala-D-Glu]-)n. The enzyme deacetylates N-acetylmuramic acid not N-acetyl-D-glucosamine from the polymer. The enzyme PdaC is a unique enzyme exhibiting two different deacetylase activities. The enzyme works as a MurNAc deacetylase toward glycan strands containing L-Ala-D-Glu
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
-
substrates: peptidoglycans digested by DL-endopeptidase, or by LD-endopeptidase, or by L-alanine amidase, the latter is a very poor substrate. Purified recombinant and truncated enzyme, expressed in Escherichia coli, deacetylates Bacillus subtilis peptidoglycan and its polymer, (-GlcNAc-MurNAc[-L-Ala-D-Glu]-)n. The enzyme deacetylates N-acetylmuramic acid not N-acetyl-D-glucosamine from the polymer. The enzyme PdaC is a unique enzyme exhibiting two different deacetylase activities. The enzyme works as a MurNAc deacetylase toward glycan strands containing L-Ala-D-Glu
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
-
-
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
-
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
-
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
-
Helicobacter pylori is highly resistant to lysozyme (up to 50 mg/ml), but the HP310 mutant is less resistant compared with the parent strain. The peptidoglycan deacetylation appears to confer lysozyme resistance to escape immunedetection
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
the enzyme catalyzes the removal of the acetyl group from the C2 atom of N-acetylglucosamine, which is a constituent of the peptidoglycan found in the cell walls of many bacteria
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
peptidoglycan consists of alternating N-acetylglucosamine and N-acetylmuramic acid residues connected by beta-1,4 bonds and cross-linked via short peptide bridges
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
-
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
peptidoglycan consists of alternating N-acetylglucosamine and N-acetylmuramic acid residues connected by beta-1,4 bonds and cross-linked via short peptide bridges
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
-
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
the enzyme catalyzes the removal of the acetyl group from the C2 atom of N-acetylglucosamine, which is a constituent of the peptidoglycan found in the cell walls of many bacteria
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
-
peptidoglycan N-deacetylation is an important modification of Listeria peptidoglycan, which allows this human pathogen to evade the innate immune system
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
-
N-acetylated murein after lysozyme digestion
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
-
-
-
?
peptidoglycan-N-acetyl-D-glucosamine + H2O
peptidoglycan-D-glucosamine + acetate
-
-
-
?
additional information
?
-
-
reaction of the deacetylase with (GlcNAc-MurNAc)3 is less than 1/100 of that with peptidoglycan, while the enzyme is inactive towards (GlcNAc-MurNAc), GlcNAc-MurNAc, and monomeric N-acetylglucosamine derivatives
-
-
?
additional information
?
-
the enzyme is inactive towards all peptidoglycan precursors
-
-
?
additional information
?
-
the enzyme is inactive towards all peptidoglycan precursors
-
-
?
additional information
?
-
the enzyme is inactive towards all peptidoglycan precursors
-
-
?
additional information
?
-
the enzyme is inactive towards all peptidoglycan precursors
-
-
?
additional information
?
-
-
PdaC acts as a GlcNAc deacetylase toward chitin oligomers and as a MurNAc deacetylase toward Bacillus subtilis peptidoglycan, activity toward MurNAc is higher than toward GlcNAc
-
-
?
additional information
?
-
-
the purified recombinant enzyme shows no nuclease activity with DNA
-
-
?
additional information
?
-
-
PdaC acts as a GlcNAc deacetylase toward chitin oligomers and as a MurNAc deacetylase toward Bacillus subtilis peptidoglycan, activity toward MurNAc is higher than toward GlcNAc
-
-
?
additional information
?
-
-
the purified recombinant enzyme shows no nuclease activity with DNA
-
-
?
additional information
?
-
no substrates: N-acetyl putrescine, N-acetyl spermidine, N-acetyl cadaverine, and N-acetyl dipeptides Ac-D-Ala-D-Ala-OH, Ac-D-Ala-D-Ala-OCH3, Ac-DAla-L-Ala-OH, Ac-D-Ala-L-Ala-OCH3
-
-
?
additional information
?
-
-
no substrates: N-acetyl putrescine, N-acetyl spermidine, N-acetyl cadaverine, and N-acetyl dipeptides Ac-D-Ala-D-Ala-OH, Ac-D-Ala-D-Ala-OCH3, Ac-DAla-L-Ala-OH, Ac-D-Ala-L-Ala-OCH3
-
-
?
additional information
?
-
-
N-acetylmuramic acid is not a substrate. With N-acetylglucosamine as substrate D-glucosamine is formed
-
-
?
additional information
?
-
-
enzyme is inactive against peptidoglycans from Staphylococcus aureus, Staphylococcus carnosus or Escherichia coli. No substrate: N-acetylglucosamine
-
-
?
