Cloned (Comment) | Organism |
---|---|
gene ba1977 | Bacillus anthracis |
gene ba2944 | Bacillus anthracis |
gene bc1960 | Bacillus cereus |
gene bc3618 | Bacillus cereus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | constructure of a knockout DELTABA2944 mutant | Bacillus cereus |
additional information | constructure of a knockout DELTABA2944 mutant | Bacillus anthracis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | the enzyme does not possess a signal peptide | Bacillus cereus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidoglycan-N-acetyl-D-glucosamine + H2O | Bacillus cereus | - |
peptidoglycan-D-glucosamine + acetate | - |
? | |
peptidoglycan-N-acetyl-D-glucosamine + H2O | Bacillus anthracis | - |
peptidoglycan-D-glucosamine + acetate | - |
? | |
peptidoglycan-N-acetyl-D-glucosamine + H2O | Bacillus cereus ATCC 14579 | - |
peptidoglycan-D-glucosamine + acetate | - |
? | |
peptidoglycan-N-acetyl-D-glucosamine + H2O | Bacillus anthracis ATCC 14578 | - |
peptidoglycan-D-glucosamine + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus anthracis | Q81P72 | gene ba2944 | - |
Bacillus anthracis | Q81RR3 | gene ba1977 | - |
Bacillus anthracis ATCC 14578 | Q81P72 | gene ba2944 | - |
Bacillus anthracis ATCC 14578 | Q81RR3 | gene ba1977 | - |
Bacillus cereus | Q81AF4 | gene b3c618 | - |
Bacillus cereus | Q81EK9 | gene bc1960 | - |
Bacillus cereus ATCC 14579 | Q81AF4 | gene b3c618 | - |
Bacillus cereus ATCC 14579 | Q81EK9 | gene bc1960 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is inactive towards all peptidoglycan precursors | Bacillus cereus | ? | - |
? | |
additional information | the enzyme is inactive towards all peptidoglycan precursors | Bacillus cereus ATCC 14579 | ? | - |
? | |
peptidoglycan-N-acetyl-D-glucosamine + H2O | - |
Bacillus cereus | peptidoglycan-D-glucosamine + acetate | - |
? | |
peptidoglycan-N-acetyl-D-glucosamine + H2O | - |
Bacillus anthracis | peptidoglycan-D-glucosamine + acetate | - |
? | |
peptidoglycan-N-acetyl-D-glucosamine + H2O | - |
Bacillus cereus ATCC 14579 | peptidoglycan-D-glucosamine + acetate | - |
? | |
peptidoglycan-N-acetyl-D-glucosamine + H2O | - |
Bacillus anthracis ATCC 14578 | peptidoglycan-D-glucosamine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BA1977 | - |
Bacillus anthracis |
BA2944 | - |
Bacillus anthracis |
BC1960 | - |
Bacillus cereus |
BC3618 | - |
Bacillus cereus |
peptidoglycan deacetylase | - |
Bacillus cereus |
peptidoglycan deacetylase | - |
Bacillus anthracis |
PGNG-dac | - |
Bacillus cereus |
PGNG-dac | - |
Bacillus anthracis |
General Information | Comment | Organism |
---|---|---|
evolution | peptidoglycan deacetylases (PGNG-dacs) belong to the carbohydrate esterase family 4 (CE4) | Bacillus cereus |
evolution | peptidoglycan deacetylases (PGNG-dacs) belong to the carbohydrate esterase family 4 (CE4) | Bacillus anthracis |
malfunction | almost 100fold increase in virulence for RDELTAba1977 mutant strain when it is injected in lysM-/- mice | Bacillus anthracis |
physiological function | enzyme BA1961 participates in the biogenesis of the peptidoglycan during both elongation and cell division | Bacillus cereus |
physiological function | the enzyme is required for bacterial evasion to lysozyme and innate immune responses | Bacillus cereus |
physiological function | the enzyme is required for bacterial evasion to lysozyme and innate immune responses, for neutral polysaccharide attachment to peptidoglycan, and for polysaccharide modification | Bacillus anthracis |
physiological function | the enzyme is required for bacterial evasion to lysozyme and innate immune responses. Enzyme BA1977 is associated with lateral peptidoglycan synthesis, it is a bona fide peptidoglycan deacetylase involved in resistance to host lysozyme and required for full virulence | Bacillus anthracis |