3.4.24.26: pseudolysin

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For detailed information about pseudolysin, go to the full flat file.

Reaction

Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects =

Synonyms

A2 elastase, aeruginolysin, ealastase LasB, EC 3.4.24.4, elastase, elastase B, elastolytic metalloproteinase, EPa, LasB, LasB protease, LepA, More, Neutral metalloproteinase, PAE, PASP, PE, PsE, Pseudomonas aeruginosa elastase, Pseudomonas aeruginosa neutral metalloproteinase, Pseudomonas aeruginosa small protease, Pseudomonas elastase, Pseudomonas protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.26 pseudolysin

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Results	in table
6	Activating Compound
26	AA Sequence
24	Application
1	CAS Registry Number
14	Cloned(Commentary)
4	Crystallization (Commentary)
2	Expression
25	General Information
2	General Stability
24	IC50 Value
155	Inhibitors
18	Ki Value [mM]
26	KM Value [mM]
39	Localization
25	Metals/Ions
39	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
31	Organic Solvent Stability
87	Organism
3	PDB ID
18	pH Optimum
2	pH Range
7	pH Stability
3	pI Value
6	Posttranslational Modification
26	Protein Variants
30	Purification (Commentary)
1	Reaction
1	Reaction Type
83	Reference
2	Renatured (Commentary)
4	Source Tissue
9	Specific Activity [micromol/min/mg]
1	Storage Stability
215	Substrates and Products (Substrate)
28	Subunits
95	Synonyms
14	Temperature Optimum [°C]
3	Temperature Range [°C]
15	Temperature Stability [°C]
28	Turnover Number [1/s]

pH Stability

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pH Stability on EC 3.4.24.26 - pseudolysin

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

4.5 - 12

Pseudomonas indica

WP_084338031.1

stable

755230

5 - 11

Pseudomonas aeruginosa

-

purified enzyme, 60 min, loss of 30% activity at pH 5.0 and of 50% at pH 11.0, completely stable at pH 6.0-10.0, profile overview

717673

6 - 10

Pseudomonas aeruginosa

-

4°C, 16 h, in presence of Ca2+ stable

31116

6 - 9

2 entries

6 - 9.5

2 entries

6 - 9

Pseudomonas aeruginosa

-

-

669613

6 - 9

Pseudomonas aeruginosa

-

1 h, stable

754211

6 - 9.5

Pseudomonas aeruginosa

-

-

699056

6 - 9.5

Pseudomonas aeruginosa

-

stable at, recombinant enzyme

733746