3.4.24.26: pseudolysin
This is an abbreviated version!
For detailed information about pseudolysin, go to the full flat file.
Word Map on EC 3.4.24.26
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3.4.24.26
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thermolysin
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metalloproteinases
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collagenase
-
metalloprotease
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3.4.24.4
-
elastin
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gelatinase
-
elastases
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phosphoramidon
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pseudomonal
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stromelysin
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thermolysin-like
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metalloendopeptidase
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medicine
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thermoproteolyticus
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aureolysin
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vibriolysin
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intrastromal
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industry
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nutrition
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biotechnology
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synthesis
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pharmacology
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diagnostics
- 3.4.24.26
- thermolysin
- metalloproteinases
- collagenase
- metalloprotease
-
3.4.24.4
- elastin
- gelatinase
- elastases
- phosphoramidon
-
pseudomonal
- stromelysin
-
thermolysin-like
- metalloendopeptidase
- medicine
- thermoproteolyticus
- aureolysin
- vibriolysin
-
intrastromal
- industry
- nutrition
- biotechnology
- synthesis
- pharmacology
- diagnostics
Reaction
Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects =
Synonyms
A2 elastase, aeruginolysin, ealastase LasB, EC 3.4.24.4, elastase, elastase B, elastolytic metalloproteinase, EPa, LasB, LasB protease, LepA, More, Neutral metalloproteinase, PAE, PASP, PE, PsE, Pseudomonas aeruginosa elastase, Pseudomonas aeruginosa neutral metalloproteinase, Pseudomonas aeruginosa small protease, Pseudomonas elastase, Pseudomonas protease
ECTree
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Reference on EC 3.4.24.26 - pseudolysin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nishino, N.; Powers, J.C.
Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an affinity ligand
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1980
Pseudomonas aeruginosa
Black, W.J.; Quinn, F.; Tompkins, L.S.
Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase
J. Bacteriol.
172
2608-2613
1990
Legionella pneumophila
Morihara, K.; Tsuzuki, H.
Pseudomonas aeruginosa elastase. Affinity chromatography and some properties as a metalloneutral proteinase
Agric. Biol. Chem.
39
1123-1128
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Pseudomonas aeruginosa
-
Morihara, K.
Pseudolysin and other pathogen endopeptidases of thermolysin family
Methods Enzymol.
248
242-253
1995
Pseudomonas aeruginosa, Vibrio cholerae serotype O1
Bever, R.A.; Iglewski, B.H.
Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene
J. Bacteriol.
170
4309-4314
1988
Pseudomonas aeruginosa
Kessler, E.; Safrin, M.; Gustin, J.K.; Ohman, D.E.
Elastase and the LasA protease of Pseudomonas aeruginosa are secreted with their propeptides
J. Biol. Chem.
273
30225-30231
1998
Pseudomonas aeruginosa
Mariencheck, W.I.; Alcorn, J.F.; Palmer, S.M.; Wright, J.R.
Pseudomonas aeruginosa elastase degrades surfactant proteins A and D
Am. J. Respir. Cell Mol. Biol.
28
528-537
2003
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Dulon, S.; Leduc, D.; Cottrell, G.S.; D'Alayer, J.; Hansen, K.K.; Bunnett, N.W.; Hollenberg, M.D.; Pidard, D.; Chignard, M.
Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells
Am. J. Respir. Cell Mol. Biol.
32
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Pseudomonas aeruginosa, Pseudomonas aeruginosa (P14756)
Besson, C.; Saulnier, J.; Wallach, J.M.
Synthetic peptide substrates for a conductimetric assay of Pseudomonas aeruginosa elastase
Anal. Biochem.
237
216-223
1996
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Burns, F.R.; Paterson, C.A.; Gray, R.D.; Wells, J.T.
Inhibition of Pseudomonas aeruginosa elastase and Pseudomonas keratitis using a thiol-based peptide
Antimicrob. Agents Chemother.
34
2065-2069
1990
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Poncz, L.
Substrate inhibition of Pseudomonas aeruginosa elastase by 3-(2-furyl)acryloyl-glycyl-L-phenylalanyl-L-phenylalanine
Arch. Biochem. Biophys.
266
508-515
1988
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Padrines, M.; Bieth, J.G.
Oxidized and Met358-->Leu mutated alpha 1-proteinase inhibitor as substrates of Pseudomonas aeruginosa elastase
Biochim. Biophys. Acta
1163
61-66
1993
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Saulnier, J.M.; Curtil, F.M.; Duclos, M.C.; Wallach, J.M.
Elastolytic activity of Pseudomonas aeruginosa elastase
Biochim. Biophys. Acta
995
285-290
1989
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Kocabiyik, S.; Ergin, E.; Turkoglu, S.
Effects of metals on elastase from Pseudomonas aeruginosa SES-938-1
Biol. Trace Elem. Res.
50
25-31
1995
Pseudomonas aeruginosa, Pseudomonas aeruginosa SES-938-1
Kessler, E.; Spierer, A.
Inhibition by phosphoramidon of Pseudomonas aeruginosa elastase injected intracorneally in rabbit eyes
Curr. Eye Res.
3
1075-1078
1984
Pseudomonas aeruginosa
Spierer, A.; Kessler, E.
The effect of 2-mercaptoacetyl-L-phenylalanyl-L-leucine, a specific inhibitor of Pseudomonas aeruginosa elastase, on experimental Pseudomonas keratitis in rabbit eyes
Curr. Eye Res.
3
645-650
1984
Pseudomonas aeruginosa
Jones, A.; Elphick, H.; Pettitt, E.; Everard, M.L.; Evans, G.S.
Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase
Eur. Respir. J.
19
1136-1141
2002
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Morihara, K.; Tsuzuki, H.; Oda, K.
Protease and elastase of Pseudomonas aeruginosa: inactivation of human plasma alpha 1-proteinase inhibitor
Infect. Immun.
24
188-193
1979
Pseudomonas aeruginosa (P14756)
Kessler, E.; Israel, M.; Landshman, N.; Chechick, A.; Blumberg, S.
In vitro inhibition of Pseudomonas aeruginosa elastase by metal-chelating peptide derivatives
Infect. Immun.
38
716-723
1982
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Heck, L.W.; Morihara, K.; McRae, W.B.; Miller, E.J.
Specific cleavage of human type III and IV collagens by Pseudomonas aeruginosa elastase
Infect. Immun.
51
115-118
1986
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Poncz, L.; Jentoft, N.; Ho, M.C.; Dearborn, D.G.
Kinetics of proteolysis of hog gastric mucin by human neutrophil elastase and by Pseudomonas aeruginosa elastase
Infect. Immun.
56
703-704
1988
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Bejarano, P.A.; Langeveld, J.P.; Hudson, B.G.; Noelken, M.E.
Degradation of basement membranes by Pseudomonas aeruginosa elastase
Infect. Immun.
57
3783-3787
1989
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Häse, C.C.; Finkelstein, R.A.
Comparison of the Vibrio cholerae hemagglutinin/protease and the Pseudomonas aeruginosa elastase
Infect. Immun.
58
4011-4015
1990
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Kawamoto, S.; Shibano, Y.; Fukushima, J.; Ishii, N.; Morihara, K.; Okuda, K.
Site-directed mutagenesis of Glu-141 and His-223 in Pseudomonas aeruginosa elastase: catalytic activity, processing, and protective activity of the elastase against Pseudomonas infection
Infect. Immun.
61
1400-1405
1993
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Wolz, C.; Hohloch, K.; Ocaktan, A.; Poole, K.; Evans, R.W.; Rochel, N.; Albrecht-Gary, A.M.; Abdallah, M.A.; Doring, G.
Iron release from transferrin by pyoverdin and elastase from Pseudomonas aeruginosa
Infect. Immun.
62
4021-4027
1994
Pseudomonas aeruginosa (P14756)
Azghani, A.O.; Baker, J.W.; Shetty, S.; Miller, E.J.; Bhat, G.J.
Pseudomonas aeruginosa elastase stimulates ERK signaling pathway and enhances IL-8 production by alveolar epithelial cells in culture
Inflamm. Res.
51
506-510
2002
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Kessler, E.; Kennah, H.E.; Brown, S.I.
Pseudomonas protease. Purification, partial characterization, and its effect on collagen, proteoglycan, and rabbit corneas
Invest. Ophthalmol. Vis. Sci.
16
488-497
1977
Pseudomonas aeruginosa
Kessler, E.; Spierer, A.; Blumberg, S.
Specific inhibition of Pseudomonas aeruginosa elastase injected intracorneally in rabbit eyes
Invest. Ophthalmol. Vis. Sci.
24
1093-1097
1983
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Marquart, M.E.; Caballero, A.R.; Chomnawang, M.; Thibodeaux, B.A.; Twining, S.S.; O'Callaghan, R.J.
Identification of a novel secreted protease from Pseudomonas aeruginosa that causes corneal erosions
Invest. Ophthalmol. Vis. Sci.
46
3761-3768
2005
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa (Q5XPI6), Pseudomonas aeruginosa, Pseudomonas aeruginosa PA103 (Q5XPI6)
Fukushima, J.; Yamamoto, S.; Morihara, K.; Atsumi, Y.; Takeuchi, H.; Kawamoto, S.; Okuda, K.
Structural gene and complete amino acid sequence of Pseudomonas aeruginosa IFO 3455 elastase
J. Bacteriol.
171
1698-1704
1989
Pseudomonas aeruginosa, Pseudomonas aeruginosa IFO3455
McIver, K.; Kessler, E.; Ohman, D.E.
Substitution of active-site His-223 in Pseudomonas aeruginosa elastase and expression of the mutated lasB alleles in Escherichia coli show evidence for autoproteolytic processing of proelastase
J. Bacteriol.
173
7781-7789
1991
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
McIver, K.S.; Olson, J.C.; Ohman, D.E.
Pseudomonas aeruginosa lasB1 mutants produce an elastase, substituted at active-site His-223, that is defective in activity, processing, and secretion
J. Bacteriol.
175
4008-4015
1993
Pseudomonas aeruginosa (P14756)
Thayer, M.M.; Flaherty, K.M.; McKay, D.B.
Three-dimensional structure of the elastase of Pseudomonas aeruginosa at 1.5-A resolution
J. Biol. Chem.
266
2864-2871
1991
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Kessler, E.; Safrin, M.
The propeptide of Pseudomonas aeruginosa elastase acts an elastase inhibitor
J. Biol. Chem.
269
22726-22731
1994
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Heck, L.W.; Alarcon, P.G.; Kulhavy, R.M.; Morihara, K.; Russell, M.W.; Mestecky, J.F.
Degradation of IgA proteins by Pseudomonas aeruginosa elastase
J. Immunol.
144
2253-2257
1990
Pseudomonas aeruginosa, Pseudomonas aeruginosa IFO 3455
Azghani, A.O.; Bedinghaus, T.; Klein, R.
Detection of elastase from Pseudomonas aeruginosa in sputum and its potential role in epithelial cell permeability
Lung
178
181-189
2000
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
McKay, D.B.; Thayer, M.M.; Flaherty, K.M.; Pley, H.; Benvegnu, D.
Crystallographic structures of the elastase of Pseudomonas aeruginosa
Matrix Suppl.
1
112-115
1992
Pseudomonas aeruginosa (P14756)
Braun, P.; Bitter, W.; Tommassen, J.
Activation of Pseudomonas aeruginosa elastase in Pseudomonas putida by triggering dissociation of the propeptide-enzyme complex
Microbiology
146
2565-2572
2000
Pseudomonas aeruginosa (P14756)
-
Braun, P.; Tommassen, J.; Filloux, A.
Role of the propeptide in folding and secretion of elastase of Pseudomonas aeruginosa
Mol. Microbiol.
19
297-306
1996
Pseudomonas aeruginosa (P14756)
Galloway, D.R.
Pseudomonas aeruginosa elastase and elastolysis revisited: recent developments
Mol. Microbiol.
5
2315-2321
1991
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO-E64 (P14756)
Barbey-Morel, C.; Perlmutter, D.H.
Effect of pseudomonas elastase on human mononuclear phagocyte alpha 1-antitrypsin expression
Pediatr. Res.
29
133-140
1991
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Matheson, N.R.; Potempa, J.; Travis, J.
Interaction of a novel form of Pseudomonas aeruginosa alkaline protease (aeruginolysin) with interleukin-6 and interleukin-8
Biol. Chem.
387
911-915
2006
Pseudomonas aeruginosa
Gupta, A.; Roy, I.; Khare, S.K.; Gupta, M.N.
Purification and characterization of a solvent stable protease from Pseudomonas aeruginosa PseA
J. Chromatogr. A
1069
155-161
2005
Pseudomonas aeruginosa
Adekoya, O.A.; Willassen, N.P.; Sylte, I.
Molecular insight into pseudolysin inhibition using the MM-PBSA and LIE methods
J. Struct. Biol.
153
129-144
2006
Pseudomonas aeruginosa
Elston, C.; Wallach, J.; Saulnier, J.
New continuous and specific fluorometric assays for Pseudomonas aeruginosa elastase and LasA protease
Anal. Biochem.
368
87-94
2007
Pseudomonas aeruginosa
Lutfullah, G.; Amin, F.; Khan, Z.; Azhar, N.; Azim, M.K.; Noor, S.; Shoukat, K.
Homology modeling of hemagglutinin/protease [HA/P (vibriolysin)] from Vibrio cholerae: Sequence comparision, residue interactions and molecular mechanism
Protein J.
27
105-114
2008
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Kida, Y.; Higashimoto, Y.; Inoue, H.; Shimizu, T.; Kuwano, K.
A novel secreted protease from Pseudomonas aeruginosa activates NF-kappaB through protease-activated receptors
Cell. Microbiol.
10
1491-1504
2008
Pseudomonas aeruginosa
Cheng, M.; Takenaka, S.; Aoki, S.; Murakami, S.; Aoki, K.
Purification and characterization of an eggshell membrane decomposing protease from Pseudomonas aeruginosa strain ME-4
J. Biosci. Bioeng.
107
373-378
2009
Pseudomonas aeruginosa, Pseudomonas aeruginosa ME-4
Mun, J.J.; Tam, C.; Kowbel, D.; Hawgood, S.; Barnett, M.J.; Evans, D.J.; Fleiszig, S.M.
Clearance of Pseudomonas aeruginosa from a healthy ocular surface involves surfactant protein D and is compromised by bacterial elastase in a murine null-infection model
Infect. Immun.
77
2392-2398
2009
Pseudomonas aeruginosa PAO1
Beaufort, N.; Corvazier, E.; Hervieu, A.; Choqueux, C.; Dussiot, M.; Louedec, L.; Cady, A.; de Bentzmann, S.; Michel, J.B.; Pidard, D.
The thermolysin-like metalloproteinase and virulence factor LasB from pathogenic Pseudomonas aeruginosa induces anoikis of human vascular cells
Cell. Microbiol.
13
1149-1167
2011
Pseudomonas aeruginosa
Ghorbel-Bellaaj, O.; Khaled, H.B.; Bayoudh, A.; Younes, I.; Hmidet, N.; Jellouli, K.; Nasri, M.
Pseudomonas aeruginosa A2 elastase: Purification, characterization and biotechnological applications
Int. J. Biol. Macromol.
50
679-686
2012
Pseudomonas aeruginosa, Pseudomonas aeruginosa A2
Andrejko, M.; Mizerska-Dudka, M.
Elastase B of Pseudomonas aeruginosa stimulates the humoral immune response in the greater wax moth, Galleria mellonella
J. Invertebr. Pathol.
107
16-26
2011
Pseudomonas aeruginosa
Wei, G.; Tian, N.; Valery, A.; Zhong, Y.; Schuppan, D.; Helmerhorst, E.
Identification of pseudolysin (lasB) as an aciduric gluten-degrading enzyme with high therapeutic potential for celiac disease
Am. J. Gastroenterol.
110
899-908
2015
Acinetobacter junii, Acinetobacter junii FA10
Falciani, C.; Lozzi, L.; Scali, S.; Brunetti, J.; Bracci, L.; Pini, A.
Site-specific pegylation of an antimicrobial peptide increases resistance to Pseudomonas aeruginosa elastase
Amino Acids
46
1403-1407
2014
Pseudomonas aeruginosa
Han, M.; Wang, X.; Ding, H.; Jin, M.; Yu, L.; Wang, J.; Yu, X.
The role of N-glycosylation sites in the activity, stability, and expression of the recombinant elastase expressed by Pichia pastoris
Enzyme Microb. Technol.
54
32-37
2014
Pseudomonas aeruginosa
Wildeboer, D.; Hill, K.E.; Jeganathan, F.; Williams, D.W.; Riddell, A.D.; Price, P.E.; Thomas, D.W.; Stephens, P.; Abuknesha, R.A.; Price, R.G.
Specific protease activity indicates the degree of Pseudomonas aeruginosa infection in chronic infected wounds
Eur. J. Clin. Microbiol. Infect. Dis.
31
2183-2189
2012
Pseudomonas aeruginosa
Adekoya, O.; Sjoeli, S.; Wuxiuer, Y.; Bilto, I.; Marques, S.; Santos, M.; Nuti, E.; Cercignani, G.; Rossello, A.; Winberg, J.; Sylte, I.
Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors
Eur. J. Med. Chem.
89
340-348
2014
Bacillus thermoproteolyticus
Bian, F.; Yue, S.; Peng, Z.; Zhang, X.; Chen, G.; Yu, J.; Xuan, N.; Bi, Y.
A comprehensive alanine-scanning mutagenesis study reveals roles for salt bridges in the structure and activity of Pseudomonas aeruginosa elastase
PLoS ONE
10
e121108
2015
Pseudomonas aeruginosa
Odunuga, O.; Adekoya, O.; Sylte, I.
High-level expression of pseudolysin, the extracellular elastase of Pseudomonas aeruginosa, in Escherichia coli and its purification
Protein Expr. Purif.
113
79-84
2015
Pseudomonas aeruginosa
Yang, J.; Zhao, H.; Ran, L.; Li, C.; Zhang, X.; Su, H.; Shi, M.; Zhou, B.; Chen, X.; Zhang, Y.
Mechanistic insights into elastin degradation by pseudolysin, the major virulence factor of the opportunistic pathogen Pseudomonas aeruginosa
Sci. Rep.
5
9936
2015
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Galdino, A.C.M.; de Oliveira, M.P.; Ramalho, T.C.; de Castro, A.A.; Branquinha, M.H.; Santos, A.L.S.
Anti-virulence strategy against the multidrug-resistant bacterial pathogen Pseudomonas aeruginosa pseudolysin (elastase B) as a potential druggable target
Curr. Protein Pept. Sci.
20
471-487
2019
Pseudomonas aeruginosa
Jose, D.; Mohandas, A.; Bright Singh, I.
Bioprocess technology for LasB protease (elastase) production from Pseudomonas aeruginosa MCCB 123
Indian J. Biotechnol.
17
284-289
2018
Pseudomonas aeruginosa (G1EMI7), Pseudomonas aeruginosa MCCB 123 (G1EMI7)
-
Casilag, F.; Lorenz, A.; Krueger, J.; Klawonn, F.; Weiss, S.; Haeussler, S.
The LasB elastase of Pseudomonas aeruginosa acts in concert with alkaline protease AprA to prevent flagellin-mediated immune recognition
Infect. Immun.
84
162-171
2016
Pseudomonas aeruginosa (Q02RJ6), Pseudomonas aeruginosa UCBPP-PA14 (Q02RJ6)
Said, Z.S.A.M.; Arifi, F.A.M.; Salleh, A.B.; Rahman, R.N.Z.R.A.; Leow, A.T.C.; Latip, W.; Ali, M.S.M.
Unravelling protein -organic solvent interaction of organic solvent tolerant elastase from Pseudomonas aeruginosa strain K crystal structure
Int. J. Biol. Macromol.
127
575-584
2019
Pseudomonas aeruginosa (A7LI11)
Kotb, E.; El-Zawahry, Y.; Saleh, G.
Isolation of a putative virulence agent, cytotoxic serine-elastase, from a newly isolated Pseudomonas aeruginosa ZuhP13
J. Biosci.
44
7
2019
Pseudomonas aeruginosa, Pseudomonas aeruginosa ZuhP13
Smith, K.; Rajendran, R.; Kerr, S.; Lappin, D.F.; Mackay, W.G.; Williams, C.; Ramage, G.
Aspergillus fumigatus enhances elastase production in Pseudomonas aeruginosa co-cultures
Med. Mycol.
53
645-655
2015
Pseudomonas aeruginosa
Li, Y.; Bai, F.; Xia, H.; Zhuang, L.; Xu, H.; Jin, Y.; Zhang, X.; Bai, Y.; Qiao, M.
A novel regulator PA5022 (aefA) is involved in swimming motility, biofilm formation and elastase activity of Pseudomonas aeruginosa
Microbiol. Res.
176
14-20
2015
Pseudomonas aeruginosa, Pseudomonas aeruginosa PA68
van der Plas, M.J.; Bhongir, R.K.; Kjellstroem, S.; Siller, H.; Kasetty, G.; Moergelin, M.; Schmidtchen, A.
Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
Nat. Commun.
7
11567
2016
Pseudomonas aeruginosa (P14756), Pseudomonas aeruginosa
Shinji, T.; Moe, Y.; Yukihiro, K.; Yoko, Y.; Hitoshi, A.
Characterization of an organic-solvent-stable elastase from Pseudomonas indica and its potential use in eggshell membrane hydrolysis
Proc. Biochem.
85
156-163
2019
Pseudomonas indica (WP_084338031.1), Pseudomonas indica NBRC 103045 (WP_084338031.1)
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