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3.4.24.26: pseudolysin

This is an abbreviated version!
For detailed information about pseudolysin, go to the full flat file.

Word Map on EC 3.4.24.26

Reaction

Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects =

Synonyms

A2 elastase, aeruginolysin, ealastase LasB, EC 3.4.24.4, elastase, elastase B, elastolytic metalloproteinase, EPa, LasB, LasB protease, LepA, More, Neutral metalloproteinase, PAE, PASP, PE, PsE, Pseudomonas aeruginosa elastase, Pseudomonas aeruginosa neutral metalloproteinase, Pseudomonas aeruginosa small protease, Pseudomonas elastase, Pseudomonas protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.26 pseudolysin

KI Value

KI Value on EC 3.4.24.26 - pseudolysin

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.034
2-mercaptoacetyl-Leu-Dphe
at pH 7.5 and 25°C, with furylacryloyl-glycyl-L-leucyl-L-alanine as substrate
0.0015
2-mercaptoacetyl-Leu-Phe
at pH 7.5 and 25°C, with furylacryloyl-glycyl-L-leucyl-L-alanine as substrate
0.0002
2-mercaptoacetyl-Phe-Leu
at pH 7.5 and 25°C, with furylacryloyl-glycyl-L-leucyl-L-alanine as substrate
4
3-(2-furyl)acryloyl-glycine
-
5
3-(2-furyl)acryloyl-glycyl-L-phenylalanyl-L-phenylalanine
-
0.028
benzyloxycarbonyl-Gly-NHOH
at pH 7.5 and 25°C, with furylacryloyl-glycyl-L-leucyl-L-alanine as substrate
6.2
benzyloxycarbonyl-L-leucine
at pH 7.5 and 25°C, with furylacryloyl-glycyl-L-leucyl-L-alanine as substrate
5
benzyloxycarbonyl-L-phenylalanine
at pH 7.5 and 25°C, with furylacryloyl-glycyl-L-leucyl-L-alanine as substrate
0.011
benzyloxycarbonyl-Leu-NHOH
at pH 7.5 and 25°C, with furylacryloyl-glycyl-L-leucyl-L-alanine as substrate
0.021
benzyloxycarbonyl-Phe-NHOH
at pH 7.5 and 25°C, with furylacryloyl-glycyl-L-leucyl-L-alanine as substrate
1.5
L-phenylalanyl-L-phenylalanine
-
1.1
Leu-Phe
at pH 7.5 and 25°C, with furylacryloyl-glycyl-L-leucyl-L-alanine as substrate
0.000041
N-mercaptoacetyl-Phe-Tyr-amide
-
pH and temperature not specified in the publication
0.4
Phe-Leu
at pH 7.5 and 25°C, with furylacryloyl-glycyl-L-leucyl-L-alanine as substrate
0.0002
phosphoryl-L-leucyl-L-phenylalanine
at pH 7.5 and 25°C, with furylacryloyl-glycyl-L-leucyl-L-alanine as substrate
0.0004
rapidly eluting isomer of HSCH2(DL)CH[CH2CH(CH3)2]CO-Phe-Ala-NH2
-
-
0.00003
S-homoPhe [N-alpha-alpha]Phe-IsoAsn
-
0.0003
slowly eluting isomer of HSCH2(DL)CH[CH2CH(CH3)2]CO-Phe-Ala-NH2
-
-