3.4.24.26: pseudolysin

This is an abbreviated version!
For detailed information about pseudolysin, go to the full flat file.

Word Map on EC 3.4.24.26

3.4.24.26

thermolysin

metalloproteinases

collagenase

metalloprotease

3.4.24.4

elastin

gelatinase

elastases

phosphoramidon

pseudomonal

stromelysin

thermolysin-like

metalloendopeptidase

medicine

thermoproteolyticus

aureolysin

vibriolysin

intrastromal

industry

nutrition

biotechnology

synthesis

pharmacology

diagnostics

Reaction

Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects =

Synonyms

A2 elastase, aeruginolysin, ealastase LasB, EC 3.4.24.4, elastase, elastase B, elastolytic metalloproteinase, EPa, LasB, LasB protease, LepA, More, Neutral metalloproteinase, PAE, PASP, PE, PsE, Pseudomonas aeruginosa elastase, Pseudomonas aeruginosa neutral metalloproteinase, Pseudomonas aeruginosa small protease, Pseudomonas elastase, Pseudomonas protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.26 pseudolysin

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Results	in table
6	Activating Compound
26	AA Sequence
24	Application
1	CAS Registry Number
14	Cloned(Commentary)
4	Crystallization (Commentary)
2	Expression
25	General Information
2	General Stability
24	IC50 Value
155	Inhibitors
18	Ki Value [mM]
26	KM Value [mM]
39	Localization
25	Metals/Ions
39	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
31	Organic Solvent Stability
87	Organism
3	PDB ID
18	pH Optimum
2	pH Range
7	pH Stability
3	pI Value
6	Posttranslational Modification
26	Protein Variants
30	Purification (Commentary)
1	Reaction
1	Reaction Type
83	Reference
2	Renatured (Commentary)
4	Source Tissue
9	Specific Activity [micromol/min/mg]
1	Storage Stability
215	Substrates and Products (Substrate)
28	Subunits
95	Synonyms
14	Temperature Optimum [°C]
3	Temperature Range [°C]
15	Temperature Stability [°C]
28	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.24.26 - pseudolysin

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casein + H2O

2 entries

Elastin + H2O

2 entries

Fibronectin + H2O

Pseudomonas aeruginosa

flagellin + H2O

Gliadin + H2O

gluten + H2O

human thrombin + H2O

Pseudomonas aeruginosa

P14756

digestion of thrombin by Pseudomonas aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns in vitro and in vivo by preventing toll-like receptor dimerization and subsequent activation of down-stream signalling pathways the enzyme cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses

754837

PAR2 + H2O

Pseudomonas aeruginosa

P14756

663600

i.e. proteinase-activated receptor 2, enzyme cleaves the N-terminal domain of PAR2 from the cell surface without triggering receptor endocytosis as trypsin does. Cleavage does not activate PAR2, but disarms the recptor for subsequent activation by trypsin

Vitronectin + H2O

Pseudomonas aeruginosa

717465

additional information

3 entries