3.4.23.B3: equine infectious anemia virus proteinase

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For detailed information about equine infectious anemia virus proteinase, go to the full flat file.

Reaction

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-/-PIVQ- cleavage site. =

Synonyms

EIAV PR, EIAV proteinase, EIAV retropepsin, EIAV-PR, equine infectious anemia virus retropepsin, More

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B3 equine infectious anemia virus proteinase

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Results	in table
2	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
4	Crystallization (Commentary)
9	Inhibitors
1	Ki Value [mM]
40	KM Value [mM]
1	Localization
1	Metals/Ions
2	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
12	Organism
1	pH Optimum
1	pH Range
1	Posttranslational Modification
4	Protein Variants
3	Purification (Commentary)
3	Reaction
1	Reaction Type
12	Reference
64	Substrates and Products (Substrate)
4	Subunits
9	Synonyms
1	Temperature Optimum [°C]
45	Turnover Number [1/s]

Cloned

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Cloned on EC 3.4.23.B3 - equine infectious anemia virus proteinase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

expression in Escherichia coli

equine infectious anemia virus

-

647821

expression in Escherichia coli as a Pol precursor protein

equine infectious anemia virus

-

647826

expression of the mutant enzyme I54G in Escherichia coli. The wild-type enzyme does not accumulate in Escherichia coli at a level sufficient for purifying enough material to homogeneity for crystallization

equine infectious anemia virus

-

647823

phylogenetic analysis, comparison to other retroviruses, overview

equine infectious anemia virus

P32542

666190

the enzyme is encoded in the 5' part of the pol gene, expression as part of the Gag-Pol polyprotein precursor, expression in Escherichia coli

equine infectious anemia virus

-

668794