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3.4.23.B3: equine infectious anemia virus proteinase

This is an abbreviated version!
For detailed information about equine infectious anemia virus proteinase, go to the full flat file.

Word Map on EC 3.4.23.B3

Reaction

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-/-PIVQ- cleavage site. =

Synonyms

EIAV PR, EIAV proteinase, EIAV retropepsin, EIAV-PR, equine infectious anemia virus retropepsin, More

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.B3 equine infectious anemia virus proteinase

KM Value

KM Value on EC 3.4.23.B3 - equine infectious anemia virus proteinase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.35
AAQTCYNCGK
-
pH 5.6, 37°C
0.02
AKLVLAQLSK
-
pH 5.6, 37°C
0.6
APKVCFKCKQ
-
pH 5.6, 37°C
0.01
Gln-Lys-2-aminohexanoic acid-2-aminohexanoic acid-Leu-p-nitrophenylalanine-Ala-Lys-Ala-Leu
-
pH 4.7, wild-type enzyme
0.47
KMVKCFNCGK
-
pH 5.6, 37°C
0.02
KPIKCWNCGK
-
pH 5.6, 37°C
0.02 - 0.075
Lys-Ala-Arg-Ile-2-aminohexanoic acid-p-nitrophenylalanine-Glu-Ala-2-aminohexanoic acid-NH2
0.01 - 0.105
Lys-Ala-Arg-Leu-2-aminohexanoic acid-p-nitrophenylalanine-Glu-Ala-2-aminohexanoic acid-NH2
0.01 - 0.03
Lys-Ala-Arg-Val-2-aminohexanoic acid-p-nitrophenylalanine-Asn-Ala-2-aminohexanoic acid-NH2
0.1
Lys-Ala-Arg-Val-2-aminohexanoic acid-p-nitrophenylalanine-Gln-Ala-2-aminohexanoic acid-NH2
-
pH 4.7, 25°C, wild-type enzyme
0.02 - 0.07
Lys-Ala-Arg-Val-2-aminohexanoic acid-p-nitrophenylalanine-Glu-Ala-2-aminohexanoic acid-Gly-NH2
0.04 - 0.21
Lys-Ala-Arg-Val-2-aminohexanoic acid-p-nitrophenylalanine-Thr-Ala-2-aminohexanoic acid-NH2
0.007
Lys-Ala-Arg-Val-Asn-p-nitrophenylalanine-Glu-Ala-Gly-NH2
-
pH 4.7, 25°C, wild-type enzyme
0.025 - 0.05
Lys-Ala-Arg-Val-Leu-p-nitrophenylalanine-Glu-Ala-2-aminohexanoic acid-Gly-NH2
0.035 - 0.045
Lys-Ala-Arg-Val-Nal-p-nitrophenylalanine-Glu-Ala-Gly-NH2
0.035 - 0.07
Lys-Ala-Arg-Val-Phe-p-nitrophenylalanine-Glu-Ala-2-aminohexanoic acid-Gly-NH2
0.075 - 0.205
Lys-Ala-Arg-Val-Phe-p-nitrophenylalanine-Glu-Ala-Gly-NH2
0.05 - 0.55
Lys-Ala-Arg-Val-Trp-p-nitrophenylalanine-Glu-Ala-Gly-NH2
0.06 - 0.165
Lys-Ala-Arg-Val-Tyr-p-nitrophenylalanine-Glu-Ala-Gly-NH2
0.1
Pro-Ser-Glu-Glu-Tyr-Pro-Ile-2-aminohexanoic acid-Ile-Asn
-
pH 4.7, wild-type enzyme and mutant enzyme T30D
0.08
PSEEYPIMID
-
pH 5.6, 37°C
0.27
QKQTFPIQQK
-
pH 5.6, 37°C
2.2
SQNYPIVQ
-
pH 5.6, 37°C
0.04
VSQNYPIV
-
pH 5.6, 37°C
0.31
VSQNYPIVQ
-
pH 5.6, 37°C