3.4.23.B3: equine infectious anemia virus proteinase
This is an abbreviated version!
For detailed information about equine infectious anemia virus proteinase, go to the full flat file.
Word Map on EC 3.4.23.B3
Reaction
Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-/-PIVQ- cleavage site. =
Synonyms
EIAV PR, EIAV proteinase, EIAV retropepsin, EIAV-PR, equine infectious anemia virus retropepsin, More
ECTree
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Natural Substrates Products on EC 3.4.23.B3 - equine infectious anemia virus proteinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
EIAV Gag-Pol polypetide + H2O
?
-
several cleavage sites
-
-
?
EIAV nucleocapsid protein + H2O
?
-
processing in the early phase of virus replication
-
-
?
additional information
?
-
-
the enzyme is essential for processing gag and gal-pol polyproteins in order to generate new infectious viral particles
-
-
?
additional information
?
-
-
the enzyme processes viral polyproteins into functional molecules during replication and it also cleaves viral nucleocapsid protein during infection
-
-
?
additional information
?
-
-
the retropepsin is expressed as part of the Gag-Pol polyprotein precursor, the enzyme cleaves the precursor into functional proteins during or after assembly and budding of the virions, thereby releasing itself
-
-
?
