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3.4.22.B61: cathepsin L5

This is an abbreviated version!
For detailed information about cathepsin L5, go to the full flat file.

Word Map on EC 3.4.22.B61

Reaction

cathepsin L5 does not exhibit substantial catalytic activity against substrates containing proline in the P2 position (thereby distinguished from Fasciola cathepsin L1, L2 and L3) =

Synonyms

Cat L5, cathepsin L5, CatL5, FhCatL5, FhCL5, FhpCL5

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B61 cathepsin L5

Engineering

Engineering on EC 3.4.22.B61 - cathepsin L5

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L69C
the mutation results in low overall activity
L69F
the mutant shows a 2-3fold increase in the ability to cleave substrates with P2 proline
L69S
the mutation results in low overall activity
L69W
the mutation results in an increased preference for substrates containing proline at P2. The mutant shows increased Km values for benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin and tosyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin compared to the wild type enzyme, but show increased catalytic efficiency for tosyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin