3.4.22.B61: cathepsin L5
This is an abbreviated version!
For detailed information about cathepsin L5, go to the full flat file.
Word Map on EC 3.4.22.B61
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3.4.22.B61
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fasciola
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cathepsins
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hepatica
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fluke
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subsite
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medicine
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evasion
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l-like
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gigantica
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helminth
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cattle
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sheep
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metacercariae
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stage-specific
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excysted
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multivalent
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veterinary
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agriculture
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diagnostics
- 3.4.22.B61
- fasciola
- cathepsins
- hepatica
- fluke
-
subsite
- medicine
-
evasion
-
l-like
- gigantica
-
helminth
- cattle
- sheep
-
metacercariae
-
stage-specific
-
excysted
-
multivalent
-
veterinary
- agriculture
- diagnostics
Reaction
cathepsin L5 does not exhibit substantial catalytic activity against substrates containing proline in the P2 position (thereby distinguished from Fasciola cathepsin L1, L2 and L3) =
Synonyms
Cat L5, cathepsin L5, CatL5, FhCatL5, FhCL5, FhpCL5
ECTree
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Engineering
Engineering on EC 3.4.22.B61 - cathepsin L5
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L69F
the mutant shows a 2-3fold increase in the ability to cleave substrates with P2 proline
L69W
the mutation results in an increased preference for substrates containing proline at P2. The mutant shows increased Km values for benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin and tosyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin compared to the wild type enzyme, but show increased catalytic efficiency for tosyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin
L69Y
substantial increase in the ability to accommodate substrates with a proline residue in the P2
L69Y
the mutant shows a 2-3fold increase in the ability to cleave substrates with P2 proline