3.4.22.B61: cathepsin L5

This is an abbreviated version!
For detailed information about cathepsin L5, go to the full flat file.

Reaction

cathepsin L5 does not exhibit substantial catalytic activity against substrates containing proline in the P2 position (thereby distinguished from Fasciola cathepsin L1, L2 and L3) =

Synonyms

Cat L5, cathepsin L5, CatL5, FhCatL5, FhCL5, FhpCL5

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B61 cathepsin L5

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Results	in table
2	AA Sequence
6	Application
8	Cloned(Commentary)
1	General Information
1	Inhibitors
14	kcat/KM [mM/s]
20	KM Value [mM]
1	Localization
2	Molecular Weight [Da]
8	Organism
2	pH Optimum
1	pH Stability
1	Posttranslational Modification
6	Protein Variants
5	Purification (Commentary)
1	Reaction
8	Reference
1	Renatured (Commentary)
2	Source Tissue
15	Substrates and Products (Substrate)
2	Subunits
10	Synonyms
1	Temperature Optimum [°C]
20	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.4.22.B61 - cathepsin L5

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

Albumin + H2O

?

Fasciola hepatica

Q9NB30

weak substrate

717293

-

-

?

benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O

benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin

Fasciola hepatica

Q9NB30

CatL5 has a clear preference for benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin over tosyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin

717293

-

-

?

benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O

benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin

Fasciola hepatica

Q9NB30

-

695026

-

-

?

casein + H2O

?

Fasciola hepatica

Q9NB30

-

717293

-

-

?

Hemoglobin + H2O

?

Fasciola hepatica

Q9NB30

cathepsin l5 hydrolyzes hemoglobin only at pH 5.5

717293

-

-

?

Immunoglobulin + H2O

?

Fasciola hepatica

Q9NB30

-

717293

-

-

?

tosyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin + H2O

tosyl-Gly-L-Pro-L-Arg + 7-amino-4-methylcoumarin

Fasciola hepatica

Q9NB30

weak substrate

717293

-

-

?

tosyl-Gly-Phe-Arg-7-amido-4-methylcoumarin + H2O

tosyl-Gly-Phe-Arg + 7-amino-4-methylcoumarin

Fasciola hepatica

Q9NB30

-

695026

-

-

?

tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O

tosyl-Gly-Pro-Arg + 7-amino-4-methylcoumarin

Fasciola hepatica

Q9NB30

-

695026, 731372

-

-

?

type 1 collagen + H2O

?

Fasciola hepatica

Q9NB30

efficient cleavage of type 1 collagen by CatL5 is limited to the beta-and gamma-chains

717293

-

-

?

type 4 collagen + H2O

?

Fasciola hepatica

Q9NB30

-

717293

-

-

?

Z-Phe-Arg-7-amido-4-methylcoumarin + H2O

Z-Phe-Arg + 7-amino-4-methylcoumarin

Fasciola hepatica

Q9NB30

preferred substrate

731372

-

-

?

additional information

?

-

4 entries

additional information

?

-

Fasciola hepatica

Q9NB30

cathepsin L5 does not exhibit substantial catalytic activity against substrates containing proline in the P2 position

695026

-

-

?

additional information

?

-

Fasciola hepatica

-

cathepsin L5 does not exhibit substantial catalytic activity against substrates containing proline in the P2 position

695026

-

-

?

additional information

?

-

Fasciola hepatica

Q9NB30

no activity with PFR-7-amido-4-methylcoumarin, Boc-DPR-7-amido-4-methylcoumarin, Boc-AGPR-7-amido-4-methylcoumarin, Boc-VPR-7-amido-4-methylcoumarin, D-Val-Leu-Arg-7-amido-4-methylcoumarin, Boc-VLK-7-amido-4-methylcoumarin, and benzoyl-FVR-7-amido-4-methylcoumarin

717293

-

-

?

additional information

?

-

Fasciola hepatica

-

no activity with PFR-7-amido-4-methylcoumarin, Boc-DPR-7-amido-4-methylcoumarin, Boc-AGPR-7-amido-4-methylcoumarin, Boc-VPR-7-amido-4-methylcoumarin, D-Val-Leu-Arg-7-amido-4-methylcoumarin, Boc-VLK-7-amido-4-methylcoumarin, and benzoyl-FVR-7-amido-4-methylcoumarin

717293

-

-

?