3.4.22.63: caspase-10
This is an abbreviated version!
For detailed information about caspase-10, go to the full flat file.
Word Map on EC 3.4.22.63
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3.4.22.63
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caspase-8
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necrosis
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fadd
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trail
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apoptosis-inducing
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bid
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lymphoproliferative
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factor-related
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death-inducing
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fas-associated
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casp11
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fas-mediated
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trail-induced
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c-flips
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tnf-related
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lymphadenopathy
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faslg
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caspase-8-deficient
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trail-mediated
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cflar
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apaf-1
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z-ietd-fmk
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tnf-r1
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trail-resistant
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template-based
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medicine
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pharmacology
- 3.4.22.63
- caspase-8
- necrosis
- fadd
-
trail
-
apoptosis-inducing
- bid
-
lymphoproliferative
-
factor-related
-
death-inducing
-
fas-associated
-
casp11
-
fas-mediated
-
trail-induced
- c-flips
-
tnf-related
- lymphadenopathy
-
faslg
-
caspase-8-deficient
-
trail-mediated
-
cflar
- apaf-1
-
z-ietd-fmk
-
tnf-r1
-
trail-resistant
-
template-based
- medicine
- pharmacology
Reaction
strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp-/-Gly =
Synonyms
apoptotic protease Mch-4, C14.011, CASP10, caspase 10, caspase-10, caspase-10/b, caspase-10beta, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, ICE-like apoptotic protease 4, Mch4
ECTree
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Subunits
Subunits on EC 3.4.22.63 - caspase-10
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dimer
monomer
1 * 61000, about, sequence calculation, mature enzyme, 1 * 103500, recombinant maltose-binding protein-fusion enzyme, SDS-PAGE
additional information
caspase-10 follows the proximity-induced dimerization model for apical caspases. Chemically inducible dimerization fusions activate the wild-type but not the cleavage site mutant caspase-10
dimer
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caspases can only be active as dimers, since neither the active site dyad nor the substrate pocket can be formed in the monomeric form
the enzyme contains two death effector domains (DED) in the N-terminal at 2-77 and 87-154 and it contains caspase family p20 domain (large subunit) and caspase family p10 domain (small subunit) in the C-terminal at 299-425 and 449-536 respectively
additional information
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the enzyme contains two death effector domains (DED) in the N-terminal at 2-77 and 87-154 and it contains caspase family p20 domain (large subunit) and caspase family p10 domain (small subunit) in the C-terminal at 299-425 and 449-536 respectively
additional information
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proMch4 can autoprocess after Asp-219 and Asp-372 to generate the two subunits of the mature enzyme: P17, the large subunit and p12, the small subunit
additional information
homology modelling of caspase-10, structural modeling based on the structure of procaspase-8, PDB ID 2K7Z
additional information
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homology modelling of caspase-10, structural modeling based on the structure of procaspase-8, PDB ID 2K7Z