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3.4.22.63: caspase-10

This is an abbreviated version!
For detailed information about caspase-10, go to the full flat file.

Word Map on EC 3.4.22.63

Reaction

strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp-/-Gly =

Synonyms

apoptotic protease Mch-4, C14.011, CASP10, caspase 10, caspase-10, caspase-10/b, caspase-10beta, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, ICE-like apoptotic protease 4, Mch4

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.63 caspase-10

Activating Compound

Activating Compound on EC 3.4.22.63 - caspase-10

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-(acetyloxy)benzoic acid 4-(nitrooxymethyl)-phenyl ester
-
i.e. para-NO-ASA, activates proteolytic enzyme activation. The compund inhibits the proliferation and induces cell death in acute lymphoblastic leukemia cell lines and patient samples
caspase-8
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caspase-8 cleaves and activates caspase-10 directly
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FLICE-like inhibitory protein
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i.e. FLIPL, activation occurs independently of cleavage of either the caspase or FLIPL
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FLIPL protein
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heterodimerization with the long isoform of cFLIP, FLIPL, leads to activation of caspase-10. The heterodimer of caspase-10 with FLIPL still can cleave Bid and induce intrinsic apoptosis
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Sodium citrate
activates the wild-type enzyme up to 500fold and the D297A mutant 100fold at up to 1.0 M, is inhibitory above probably due to precipitation
additional information
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