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Ac-IETD-4-trifluoromethylcoumarin-7-amide + H2O
Ac-IETD + 7-amino-4-trifluoromethylcoumarin
-
-
-
?
acetyl-Ala-Glu(OMe)-Val-Asp(OMe)-7-amido-4-methylcoumarin + H2O
?
-
-
-
-
?
acetyl-Ala-Glu-Val-Asp-4-trifluoromethylcoumarin-7-amide + H2O
acetyl-Ala-Glu-Val-Asp + 7-amino-4-trifluoromethylcoumarin
-
-
-
-
?
acetyl-aspartyl-glutamyl-valinyl-aspartyl-aminofluorocoumarin + H2O
?
-
-
-
-
?
acetyl-VEHD-7-amido-4-methylcoumarin + H2O
acetyl-VEHD + 7-amino-4-methylcoumarin
-
the optimal tetrapeptide recognition motif is LEXD
-
-
?
AEVD-4-nitroanilide + H2O
AEVD + 4-nitroaniline
-
-
-
?
B cell lymphoma-2-interacting domain + H2O
?
BID + H2O
?
cleavage at sites LQTD/G and IEPD/S, for apical caspases
-
-
?
DEVD-4-nitroanilide + H2O
DEVD + 4-nitroaniline
-
-
-
-
?
DEVD-7-amido-4-methylcoumarin + H2O
DEVD + 7-amino-4-methylcoumarin
Hsp90beta + H2O
?
-
Hsp90beta is cleaved by activated caspase-10 under UV-B irradiation at D278, P293, and D294
-
-
?
MDIGAYPHFMPTNLAGDPY + H2O
YPHFMPTNL + AYPHFMPTNL + YPHFMPTNLA + AYPHFMPTNLAG + AYPHFMPTNLAGD + DIGAYPHFMPTNLA + DIGAYPHFMPTNLAG + YPHFMPTNLAGDPY + IGAYPHFMPTNLAGD + MDIG + MDIGA + Met-Asp + Met + Tyr + Pro-Tyr + GDPY + DPY
-
-
quantitative product mass spectrometric analysis, overview
-
?
pro-Mch3 + H2O
?
cleaves the propeptide of Mch3 to generate a 33000 Da protein which is further processed to the 20000 Da band and the 12000 Da protein
-
-
?
procaspase-3 + H2O
caspase-3 + ?
-
-
-
?
procaspase-7 + H2O
caspase-7 + ?
-
-
-
?
YVAD-7-amido-4-methylcoumarin + H2O
YVAD + 7-amino-4-methylcoumarin
additional information
?
-
B cell lymphoma-2-interacting domain + H2O
?
-
-
-
-
?
B cell lymphoma-2-interacting domain + H2O
?
-
caspase-10 can serve as an initiator caspase in Fas signaling leading to Bid processing, caspase cascade activation, and apoptosis
-
-
?
B cell lymphoma-2-interacting domain + H2O
?
-
-
-
-
?
DEVD-7-amido-4-methylcoumarin + H2O
DEVD + 7-amino-4-methylcoumarin
-
-
-
?
DEVD-7-amido-4-methylcoumarin + H2O
DEVD + 7-amino-4-methylcoumarin
-
-
-
-
?
YVAD-7-amido-4-methylcoumarin + H2O
YVAD + 7-amino-4-methylcoumarin
-
-
-
?
YVAD-7-amido-4-methylcoumarin + H2O
YVAD + 7-amino-4-methylcoumarin
less efficient cleavage than DEVD-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
-
caspase-10 is involved in the early phase of advanced glycation end-product-induced pericyte apoptosis
-
-
?
additional information
?
-
-
broad specificity towards pro-aspartate-specific cysteine proteases
-
-
?
additional information
?
-
FLICE2 is a signaling caspase able to interact with the cell death receptors p55 and CD95 through the adapter molecule FADD
-
-
?
additional information
?
-
caspase-10/c is a truncated protein that is essentially a prodomain-only form of the caspase that lacks proteolytic activity in vitro but efficiently induces the formation of perinuclear filamentous structures and cell death in vivo, potential role of caspase-10/c in amplifying the apoptotic response to extracellular stimuli such as cytokines. Caspase-10/d is proteolytically active in vitro and also induces cell death ion vivo, although it is less active than Mch4. Possible role of caspase-10 family in the fetal development
-
-
?
additional information
?
-
-
the enzyme acts as initiator of apoptosis
-
-
?
additional information
?
-
inherited nonlethal caspase abnormalities cause pleiotropic apoptosis defects underlying autoimmunity in ALPS type II, caspase-10 mutations in Pt 11 and Pt 36 affect TRAIL-induced death of dendritic cells
-
-
?
additional information
?
-
-
inherited nonlethal caspase abnormalities cause pleiotropic apoptosis defects underlying autoimmunity in ALPS type II, caspase-10 mutations in Pt 11 and Pt 36 affect TRAIL-induced death of dendritic cells
-
-
?
additional information
?
-
-
caspase-8 has a role in a non-apoptotic or anti-apoptotic signaling pathway leading to NF-kappaB activation through RIP, NIK and IKKalpha
-
-
?
additional information
?
-
-
Mch4 mediates the CrmA-insensitive apoptotic pathways, such as the DNA-damaging agents and staurosporine pathways
-
-
?
additional information
?
-
-
caspase-10 actively contributes to cytotoxic drug-induced apoptosis in leukemic cells. Caspase-10 activation does not occur at the level of a death-inducing signaling complex, nor in a Fas-associated death domain-dependent manner, but requires cytochrome c release from the mitochondria and the adapter molecule Apaf-1. Caspase-10 is activated downstream of caspase-9 and amplifies the caspase cascade by activating caspase-9 and caspase-3 in a feedback loop. Caspase-10 plays a role in cytotoxic drug-induced apoptosis downstream of the mitochondria
-
-
?
additional information
?
-
-
caspase-10 is involved in RIG-I/Mda5-dependent antiviral immune responses, particularly inflammatory responses
-
-
?
additional information
?
-
-
caspase-10 sensitizes breast carcinoma cells to TNF-related apoptosis-inducing ligand-induced but not tumor necrosis factor-induced apoptosis in a caspase-3-dependent manner
-
-
?
additional information
?
-
-
genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome
-
-
?
additional information
?
-
-
spontaneous apoptosis requires the activation of caspase-10/b
-
-
?
additional information
?
-
-
caspase-10 mRNA level is increased by the treatment with sodium butyrate. Sodium butyrate may trigger apoptosis via the induction of the caspase-10 expression
-
-
?
additional information
?
-
the splice variant caspase-10g (comprising five exons including exons 2-5 and a specific exon between exons 5 and 6 of the caspase-10 gene), a prodomain-only isoform of caspase-10, may play a regulatory role preferentially in the NF-kappaB pathway. Caspase-10g induces low level of apoptosis and has no effect on the caspase-10a-mediated cell apoptosis
-
-
?
additional information
?
-
-
the splice variant caspase-10g (comprising five exons including exons 2-5 and a specific exon between exons 5 and 6 of the caspase-10 gene), a prodomain-only isoform of caspase-10, may play a regulatory role preferentially in the NF-kappaB pathway. Caspase-10g induces low level of apoptosis and has no effect on the caspase-10a-mediated cell apoptosis
-
-
?
additional information
?
-
-
xCaspase-10beta can interact with other Xenopus initiator caspases via the conformational activity of its DED, xCaspase-10beta is involved in the early development of Xenopus embryos
-
-
?
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metabolism
apoptosis is a form of programmed cell death that requires members of a family of aspartate-specific cysteine proteases, called caspases, to both initiate and execute the apoptotic phenotype
evolution
human caspase-10 and caspase-8, EC 3.4.22.61, are highly homologous in their protein sequence, 46% identical in the catalytic domain, and their genes are on the same region of human chromosome 2q33-34 suggesting that they have a common ancestor
evolution
-
initiator and executioner caspases, the pro-apoptotic members of the caspase family are subdivided in the initiators of apoptosis, i.e. caspases-8, -9 and -10 in humans, and the executioners of apoptosis, caspase-3, -6 and -7, phylogenetic tree of all the human caspases, overview. The initiators have a relatively large N-terminal dimerization domain, either a death effector domain, caspases-8 and -10, or a structurally related caspase recruitment domain, caspase-9. Caspase-18 and the ancestor of -8 and -10 called caspase-810 in this schematic are still found in fishes. Later on in evolution, caspase-8 and -10 branched off from caspase-810
malfunction
-
addition of a caspase-10 inhibitor totally blocks PTK7-knockdown-induced apoptosis
malfunction
-
caspase-10 silencing in neuroblastoma is cell-type related. Downregulation of individual or all caspase-10 isoforms in SH-EP cells does not affect TRAIL sensitivity
malfunction
-
mutations or deficiencies in caspase-10 are associated with autoimmune lymphoproliferative syndrome
malfunction
-
apoptosis is totally prevented when caspase-10 is specifically inhibited in the cells
physiological function
-
caspase-10 activation is important in the initiation phase of apoptosis
physiological function
-
flunarizine triggers apoptosis in Jurkat cells via FADD-independent activation of caspase-10
physiological function
-
activation of caspase-10 in apoptosis is induced by PTK7 knockdown. Caspase-10 may play a critical role in PTK7-knockdown-induced apoptosis, downstream of mitochondria. The intrinsic pathway, i.e. mitochondria pathway, involves a decrease in mitochondrial membrane potential and release of cytochrome, overview
physiological function
-
caspase-10 is an initiator caspase of proinflammatory and apoptotic pathways induced by vaccinia infection. The processing of a short vaccinia virus-encoded antigen can take place by a proteasome-independent pathway involving initiator caspase-5 and -10, which generate antigenic peptides recognized by CD8+ T lymphocytes. Each enzyme can use the degradation products of the other as substrate for new cleavages, indicating concerted endoproteolytic activity of caspase-5 and -10, EC 3.4.22.58 and EC 3.4.22.63
physiological function
-
individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis in several tumour cell types. Distinct caspase-10 isoforms induce opposed apoptotic signals in NB cells. Isozymes caspase-10A and -10D strongly increase tumour necrosis factor-related apoptosis-inducing ligand, i.e. TRAIL, and FasL sensitivity, whereas caspase-10B or -10G have no effect or are weakly anti-apoptotic. The unique C-terminal end of caspase-10B is responsible for its degradation by the ubiquitin-proteasome pathway and for its lack of pro-apoptotic activity compared with caspase-10A and -10D. Functional comparison to caspase-8, EC 3.4.22.61, overview. Caspase-10A or -10D isoforms can substitute for caspase-8 in the initiation extrinsic apoptosis
physiological function
prodeath role for both cleaved and uncleaved caspase-10
physiological function
-
apoptosis is dependent on caspase-10 in association with the formation of the death-inducing signaling complex (DISC) incorporating pro-caspase-10 and tumor necrosis factor receptor 1 (TNF-R1), the process is ligand-independent
physiological function
-
caspase-10 is the key initiator caspase involved in tributyltin-mediated apoptosis in immune cells. Caspase-10 is recruited by the TRAIL-R2 receptor
physiological function
-
Smac mimetic-induced cell death is associated with caspase-10 activation and is Bid-independent, suggesting that in the absence of caspase-8, caspase-10 mediates response to Smac mimetics, overview
physiological function
the enzyme is involved in immunity reactions against infection by Aphanomyces invadans and bacteria Aeromonas hydrophila
physiological function
caspase-10 negatively regulates caspase-8-mediated cell death. Caspase-10 reduces death-inducing signaling complex DISC association and activation of caspase-8. Caspase-10 does not compete with caspase-8 for binding to adaptor protein FADD. Caspase-8 is required upstream of both regulator cFLIP and caspase-10 and DISC formation critically depends on the scaffold function of caspase-8. Caspase-10 rewires DISC signaling to NF-kappaB activation/cell survival and the catalytic activity of caspase-10, and caspase-8, is redundant in gene induction
physiological function
the apoptosis-inducing complex FADDosome is driven by ATR-dependent caspase-10 upregulation. During FADDosome-induced apoptosis, FLICE-inhibitory protein cFLIPL is ubiquitinated by TRAF2, leading to its degradation and subsequent adaptor protein FADD-dependent caspase-8 activation. Cancer cells lacking caspase-10, TRAF2 or ATR switch from this cell-autonomous suicide to a more effective, autocrine/paracrine mode of apoptosis initiated by a different complex, the FLIPosome. It leads to processing of cFLIPL to cFLIPp43, TNF-alpha production and consequently, contrary to the FADDosome, p53-independent apoptosis
additional information
-
isozymes caspase-10B and -10A/B are protected from CHX-mediated degradation by lactacystin treatment
additional information
residue D297 is essential for autocleavage, while even though the sequence surrounding D319 is compatible for cleavage by caspase-10, its location close to the compact core makes it unavailable for cleavage
additional information
-
residue D297 is essential for autocleavage, while even though the sequence surrounding D319 is compatible for cleavage by caspase-10, its location close to the compact core makes it unavailable for cleavage
additional information
-
the heterodimer of caspase-10 with FLIPL still can cleave Bid and induce intrinsic apoptosis
additional information
-
autophagy is associated to human caspase-10-induced cell death in yeast, a specific process that depends on an intact MAPK pathway, the Factor-arrest (Far) protein family, and the autophagy machinery, overview. Far11 coordinates a death-promoting signal and regulates both autophagy and the DNA damage response. The expression of human caspase-10 in Saccharomyces cerevisiae activates an intracellular death signal that depends on the Far protein complex. Expression of initiator caspase-10 is toxic in yeast and induces a lethal phenotype with most of the principal hallmarks of apoptosis and autophagy, which include the production of ROS, chromatin condensation, phosphatidylserine externalization, and increased vacuolization. The MAP kinases Fus3, Kss1, and Slt2 are activated after the expression of caspase-10 in yeast cells
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Garcia-Calvo, M.; Peterson, E.P.; Leiting, B.; Ruel, R.; Nicholson, D.W.; Thornberry, N.A.
Inhibition of human caspases by peptide-based and macromolecular inhibitors
J. Biol. Chem.
273
32608-32613
1998
Homo sapiens
brenda
Garcia-Calvo, M.; Peterson, E.P.; Rasper, D.M.; Vaillancourt, J.P.; Zamboni, R.; Nicholson, D.W.; Thornberry, N.A.
Purification and catalytic properties of human caspase family members
Cell Death Differ.
6
362-369
1999
Homo sapiens
brenda
Chang, H.Y.; Yang, X.
Proteases from cell suicide: functions and regulation of caspases
Microbiol. Mol. Biol. Rev.
64
821-846
2000
Homo sapiens
brenda
Fernandes-Alnemri, T.; Armstrong, R.C.; Krebs, J.F.; Srinivasula, S.M.; Wang, L.; Bullrich, F.; Fritz, L.C.; Trapani, J.A.; Tomaselli, K.J.; Litwack, G.; Alnemri, E.S.
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
Proc. Natl. Acad. Sci. USA
93
7464-7469
1996
Homo sapiens (Q92851)
brenda
Srinivasula, S.M.; Ahmad, M.; Fernandes-Almeri, T.; Liwack, G.; Alnemri, E.S.
Molecular ordering of the Fas-apoptotic pathway: the fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteien proteases
Proc. Natl. Acad. Sci. USA
93
14486-14491
1996
Homo sapiens
brenda
Vincenz, C.; Dixit, V.M.
Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling
J. Biol. Chem.
272
6578-6583
1997
Homo sapiens (Q92851)
brenda
Ng P.W.; Porter A.G.; Janicke R.U.
Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10
J. Biol. Chem.
274
10301-10308
1999
Homo sapiens (Q92851)
brenda
Shikama, Y.; Yamada, M.; Miyashita, T.
Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases
Eur. J. Immunol.
33
1998-2006
2003
Homo sapiens
brenda
Wang J.; Zheng L.; Lobito A.; Chan F.K.; Dale J.; Sneller M.; Yao X.; Puck J.M.; Straus S.E.; Lenardo M.J.
Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
Cell
98
47-58
1999
Homo sapiens (Q92851), Homo sapiens
brenda
Boatright, K.M.; Deis, C.; Denault, J.B.; Sutherlin, D.P.; Salvesen, G.S.
Activiation of caspases-8 and -10 by FLIP L
Biochem. J.
382
651-657
2004
Homo sapiens
brenda
Lecomte, M.; Denis, U.; Ruggiero, D.; Lagarde, M.; Wiernsperger, N.
Involvement of caspase-10 in advanced glycation end-product-induced apoptosis of bovine retinal pericytes in culture
Biochim. Biophys. Acta
1689
202-211
2004
Bos taurus
brenda
Kominami, K.; Takagi, C.; Kurata, T.; Kitayama, A.; Nozaki, M.; Sawasaki, T.; Kuida, K.; Endo, Y.; Manabe, N.; Ueno, N.; Sakamaki, K.
The initiator caspase, caspase-10beta, and the BH-3-only molecule, Bid, demonstrate evolutionary conservation in Xenopus of their pro-apoptotic activities in the extrinsic and intrinsic pathways
Genes Cells
11
701-717
2006
Xenopus laevis
brenda
Zhu, S.; Hsu, A.P.; Vacek, M.M.; Zheng, L.; Schaeffer, A.A.; Dale, J.K.; Davis, J.; Fischer, R.E.; Straus, S.E.; Boruchov, D.; Saulsbury, F.T.; Lenardo, M.J.; Puck, J.M.
Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome
Hum. Genet.
119
284-294
2006
Homo sapiens
brenda
Milhas, D.; Cuvillier, O.; Therville, N.; Clave, P.; Thomsen, M.; Levade, T.; Benoist, H.; Segui, B.
Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis
J. Biol. Chem.
280
19836-19842
2005
Homo sapiens
brenda
Takahashi, K.; Kawai, T.; Kumar, H.; Sato, S.; Yonehara, S.; Akira, S.
Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA
J. Immunol.
176
4520-4524
2006
Homo sapiens
brenda
Goepel, F.; Weinmann, P.; Schymeinsky, J.; Walzog, B.
Identification of caspase-10 in human neutrophils and its role in spontaneous apoptosis
J. Leukocyte Biol.
75
836-843
2004
Homo sapiens
brenda
Engels, I.H.; Totzke, G.; Fischer, U.; Schulze-Osthoff, K.; Jaenicke, R.U.
Caspase-10 sensitizes breast carcinoma cells to TRAIL-induced but not tumor necrosis factor-induced apoptosis in a caspase-3-dependent manner
Mol. Cell. Biol.
25
2808-2818
2005
Homo sapiens
brenda
Filomenko, R.; Prevotat, L.; Rebe, C.; Cortier, M.; Jeannin, J.F.; Solary, E.; Bettaieb, A.
Caspase-10 involvement in cytotoxic drug-induced apoptosis of tumor cells
Oncogene
25
7635-7645
2006
Homo sapiens
brenda
Wang, H.; Wang, P.; Sun, X.; Luo, Y.; Wang, X.; Ma, D.; Wu, J.
Cloning and characterization of a novel caspase-10 isoform that activates NF-kB activity
Biochim. Biophys. Acta
1770
1528-1537
2007
Homo sapiens (Q92851), Homo sapiens
brenda
Cerutti, E.; Campagnoli, M.F.; Ferretti, M.; Garelli, E.; Crescenzio, N.; Rosolen, A.; Chiocchetti, A.; Lenardo, M.J.; Ramenghi, U.; Dianzani, U.
Co-inherited mutations of Fas and caspase-10 in development of the autoimmune lymphoproliferative syndrome
BMC Immunol.
8
28
2007
Homo sapiens
brenda
Kurobe, T.; Hirono, I.; Kondo, H.; Yamashita, M.; Aoki, T.
Molecular cloning, expression, and functional analysis of caspase-10 from Japanese flounder Paralichthys olivaceus
Fish Shellfish Immunol.
23
1266-1274
2007
Paralichthys olivaceus (Q0WYJ4), Paralichthys olivaceus
brenda
Nohara, K.; Yokoyama, Y.; Kano, K.
The important role of caspase-10 in sodium butyrate-induced apoptosis
Kobe J. Med. Sci.
53
265-273
2007
Homo sapiens
brenda
Lisa-Santamaria, P.; Neiman, A.M.; Cuesta-Marban, A.; Mollinedo, F.; Revuelta, J.L.; Jimenez, A.
Human initiator caspases trigger apoptotic and autophagic phenotypes in Saccharomyces cerevisiae
Biochim. Biophys. Acta
1793
561-571
2009
Homo sapiens (Q92851), Homo sapiens
brenda
Hyer, M.L.; Shi, R.; Krajewska, M.; Meyer, C.; Lebedeva, I.V.; Fisher, P.B.; Reed, J.C.
Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer
Cancer Res.
68
2927-2933
2008
Homo sapiens
brenda
Pawar, P.; Ma, L.; Byon, C.H.; Liu, H.; Ahn, E.Y.; Jhala, N.; Arnoletti, J.P.; McDonald, J.M.; Chen, Y.
Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: role of calmodulin
Clin. Cancer Res.
15
1288-1296
2009
Homo sapiens
brenda
Li, C.; Zhao, H.; Hu, Z.; Liu, Z.; Wang, L.E.; Gershenwald, J.E.; Prieto, V.G.; Lee, J.E.; Duvic, M.; Grimm, E.A.; Wei, Q.
Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma
Hum. Mutat.
29
1443-1451
2008
Homo sapiens
brenda
Su, H.C.
The technological transformation of patient-driven human immunology research
Immunol. Res.
43
167-171
2009
Homo sapiens, no activity in Mus musculus
brenda
Xu, B.; Zhou, Z.G.; Li, Y.; Wang, L.; Yang, L.; Zhou, B.; Liu, H.Y.; Song, J.M.; Zeng, Y.J.; Wang, R.; Shen, X.G.; Sun, X.F.
Clinicopathological significance of caspase-8 and caspase-10 expression in rectal cancer
Oncology
74
229-236
2008
Homo sapiens
brenda
Conrad, D.M.; Furlong, S.J.; Doucette, C.D.; West, K.A.; Hoskin, D.W.
The Ca2+ channel blocker flunarizine induces caspase-10-dependent apoptosis in Jurkat T-leukemia cells
Apoptosis
15
597-607
2010
Homo sapiens
brenda
Chen, H.; Xia, Y.; Fang, D.; Hawke, D.; Lu, Z.
Caspase-10-mediated heat shock protein 90beta cleavage promotes UVB irradiation-induced cell apoptosis
Mol. Cell. Biol.
29
3657-3664
2009
Homo sapiens
brenda
Kim, M.S.; Oh, J.E.; Min, C.K.; Lee, S.; Chung, N.G.; Yoo, N.J.; Lee, S.H.
Mutational analysis of CASP10 gene in acute leukaemias and multiple myelomas
Pathology
41
484-487
2009
Homo sapiens
brenda
Oh, J.E.; Kim, M.S.; Ahn, C.H.; Kim, S.S.; Han, J.Y.; Lee, S.H.; Yoo, N.J.
Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas
Pathology
42
73-76
2010
Homo sapiens
brenda
Wachmann, K.; Pop, C.; van Raam, B.J.; Drag, M.; Mace, P.D.; Snipas, S.J.; Zmasek, C.; Schwarzenbacher, R.; Salvesen, G.S.; Riedl, S.J.
Activation and specificity of human caspase-10
Biochemistry
49
8307-8315
2010
Homo sapiens (Q92851), Homo sapiens
brenda
van Raam, B.J.; Salvesen, G.S.
Proliferative versus apoptotic functions of caspase-8 hetero or homo: the caspase-8 dimer controls cell fate
Biochim. Biophys. Acta
1824
113-122
2012
Homo sapiens, no activity in Mus musculus
brenda
Muehlethaler-Mottet, A.; Flahaut, M.; Bourloud, K.B.; Nardou, K.; Coulon, A.; Liberman, J.; Thome, M.; Gross, N.
Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis
Cell Death Dis.
2
e125
2011
Homo sapiens
brenda
Lopez, D.; Jimenez, M.; Garcia-Calvo, M.; Del Val, M.
Concerted antigen processing of a short viral antigen by human caspase-5 and -10
J. Biol. Chem.
286
16910-16913
2011
Homo sapiens
brenda
Meng, L.; Sefah, K.; ODonoghue, M.B.; Zhu, G.; Shangguan, D.; Noorali, A.; Chen, Y.; Zhou, L.; Tan, W.
Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathway
PLoS ONE
5
e14018
2010
Homo sapiens
brenda
Raulf, N.; El-Attar, R.; Kulms, D.; Lecis, D.; Delia, D.; Walczak, H.; Papenfuss, K.; Odell, E.; Tavassoli, M.
Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10
Br. J. Cancer
111
1955-1964
2014
Homo sapiens
brenda
Arockiaraj, J.; Gnanam, A.J.; Muthukrishnan, D.; Pasupuleti, M.; Milton, J.; Singh, A.
An upstream initiator caspase 10 of snakehead murrel Channa striatus, containing DED, p20 and p10 subunits: molecular cloning, gene expression and proteolytic activity
Fish Shellfish Immunol.
34
505-513
2013
Channa striata (T1RRM8), Channa striata
brenda
Lisa-Santamaria, P.; Jimenez, A.; Revuelta, J.L.
The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling
J. Biol. Chem.
287
29636-29647
2012
Homo sapiens
brenda
Krug, H.F.
Caspase-10 is the key initiator caspase involved in tributyltin-mediated apoptosis in human immune cells
J. Toxicol.
2012
395482
2012
Homo sapiens
brenda
Cisterne, A.; Baraz, R.; Khan, N.I.; Welschinger, R.; Basnett, J.; Fung, C.; Rizos, H.; Bradstock, K.F.; Bendall, L.J.
Silencer of death domains controls cell death through tumour necrosis factor-receptor 1 and caspase-10 in acute lymphoblastic leukemia
PLoS ONE
9
e103383
2014
Homo sapiens
brenda
Mohr, A.; Deedigan, L.; Jencz, S.; Mehrabadi, Y.; Houlden, L.; Albarenque, S.M.; Zwacka, R.M.
Caspase-10 a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment
Cell Death Differ.
25
340-352
2018
Homo sapiens (Q92851)
brenda
Horn, S.; Hughes, M.A.; Schilling, R.; Sticht, C.; Tenev, T.; Ploesser, M.; Meier, P.; Sprick, M.R.; MacFarlane, M.; Leverkus, M.
Caspase-10 negatively regulates caspase-8-mediated cell death, switching the response to CD95L in favor of NF-kappaB activation and cell survival
Cell Rep.
19
785-797
2017
Homo sapiens (Q92851)
brenda
Elvitigala, D.A.; Whang, I.; Jung, H.B.; Lim, B.S.; Nam, B.H.; Lee, J.
Molecular delineation of a caspase 10 homolog from black rockfish (Sebastes schlegelii) and its transcriptional regulation in response to pathogenic stress
Gene
570
288-294
2015
Sebastes schlegelii (A0A0G4APA6)
brenda
Guo, W.; Dong, A.; Pan, X.; Lin, X.; Lin, Y.; He, M.; Zhu, B.; Jin, L.; Yao, R.
Role of caspase-10 in the death of acute leukemia cells
Oncol. Lett.
12
1623-1629
2016
Homo sapiens (Q92851)
brenda