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3.4.22.63: caspase-10

This is an abbreviated version!
For detailed information about caspase-10, go to the full flat file.

Word Map on EC 3.4.22.63

Reaction

strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp-/-Gly =

Synonyms

apoptotic protease Mch-4, C14.011, CASP10, caspase 10, caspase-10, caspase-10/b, caspase-10beta, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, ICE-like apoptotic protease 4, Mch4

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.63 caspase-10

Cloned

Cloned on EC 3.4.22.63 - caspase-10

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning of caspase-10/c and caspase-10/d isoforms
expression in Escherichia coli
expression in NIH-3T3 cells
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expression of both the long and short isoforms of the wild-type or the caspase-10 mutants are transfected into Hela or MCF-7 cells together with a bet-gal reporter construct
gene CASP10, recombinant expression of human caspase-10 in Saccharomyces cerevisiae strain strain BY4741 and derivatives, phenotypes, overview. Identification of 46 suppressors whose coexpression abolishes caspase-10 function and leads to cell curvaival and growth
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gene CsCasp10, cDNA library construction, DNA and amino acid sequence determination and analysis, phylogenetic analysis and tree, quantitative real time PCR expression analysis, recombinant expression of enzyme fused to maltose-binding protein in Escherichia coli strain BL21(DE3)
proMch4 lacking the two N-terminal FADD-like domains is subcloned in the bacterial expression vector pET21b
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splice variant caspase-10g (comprising five exons including exons 2-5 and a specific exon between exons 5 and 6 of the caspase-10 gene), expression in HeLa and JURKAT cells
the caspase-10 gene is linked to the caspase-8 gene, EC 3.4.22.61, at the human chromosome locus 2q33-34
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the caspase-10 gene is linked to the caspase-8 gene, EC 3.4.22.61, at the human chromosome locus 2q33-34. Expression of His-tagged truncated mutant, with and without the D279A mutation, in Escherichia coli strain BL21 (DE3)
the over-expression analysis of JF-caspase-10 in Japanese flounder cell line HINAE induces apoptosis 24 h post-transfection