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3.4.22.58: caspase-5

This is an abbreviated version!
For detailed information about caspase-5, go to the full flat file.

Word Map on EC 3.4.22.58

Reaction

strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/- but also cleaves at Asp-Glu-Val-Asp-/- =

Synonyms

C14.008, cas-5, caspase 5, caspase-5, caspase-5/a, caspase-5/b, ICE(rel)-III, ICErelIII/TY, ICH-3 protease, transcript Y, TY, TY protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.58 caspase-5

Reference

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Reference on EC 3.4.22.58 - caspase-5

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Garcia-Calvo, M.; Peterson, E.P.; Leiting, B.; Ruel, R.; Nicholson, D.W.; Thornberry, N.A.
Inhibition of human caspases by peptide-based and macromolecular inhibitors
J. Biol. Chem.
273
32608-32613
1998
Homo sapiens
Manually annotated by BRENDA team
Garcia-Calvo, M.; Peterson, E.P.; Rasper, D.M.; Vaillancourt, J.P.; Zamboni, R.; Nicholson, D.W.; Thornberry, N.A.
Purification and catalytic properties of human caspase family members
Cell Death Differ.
6
362-369
1999
Homo sapiens
Manually annotated by BRENDA team
Chang, H.Y.; Yang, X.
Proteases from cell suicide: functions and regulation of caspases
Microbiol. Mol. Biol. Rev.
64
821-846
2000
Homo sapiens
Manually annotated by BRENDA team
Thornberry, N.A.; Rano, T.A.; Peterson, E.P.; et al.
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
J. Biol. Chem.
272
17907-17911
1997
Homo sapiens
Manually annotated by BRENDA team
Wang, S.; Miura, M.; Jung, Y.K.; Zhu, H.; Gagliardini, V.; Shi, L.; Greenberg, A.H.; Yuan, J.
Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE
J. Biol. Chem.
271
20580-20587
1996
Mus musculus
Manually annotated by BRENDA team
Faucheu, C.; Blanchet, A.M.; Collard-Dutilleul, V.; Lalanne, J.L.; Diu-Hercend, A.
Identification of a cysteine protease closely related to interleukin-1 beta-converting enzyme
Eur. J. Biochem.
236
207-213
1996
Homo sapiens (P51878)
Manually annotated by BRENDA team
Munday N.A.; Vaillancourt J.P.; Ali A.; Casano F.J.; Miller D.K.; Molineaux S.M.; Yamin T.T.; Yu V.L.; Nicholson D.W.
Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases
J. Biol. Chem.
270
15870-15876
1995
Homo sapiens (P51878)
Manually annotated by BRENDA team
Kamada, S.; Funahashi, Y.; Tsujimoto, Y.
Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases
Cell Death Differ.
4
473-478
1997
Homo sapiens
Manually annotated by BRENDA team
Fassy, F.; Krebs, O.; Rey, H.; Komara, B.; Gillard, C.; Capdevila, C.; Yea, C.; Faucheu, C.; Blanchet, A.M.; Miossec, C.; Diu-Hercend, A.
Enzymic activity of two caspases related to interleukin-1beta-converting enzyme
Eur. J. Biochem.
253
76-83
1998
Homo sapiens
Manually annotated by BRENDA team
Eckhart, L.; Kittel, C.; Gawlas, S.; Gruber, F.; Mildner, M.; Jilma, B.; Tschachler, E.
Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants
Biochem. Biophys. Res. Commun.
348
682-688
2006
Homo sapiens (P51878), Homo sapiens
Manually annotated by BRENDA team
Trojan, J.; Brieger, A.; Raedle, J.; Weber, N.; Kriener, S.; Kronenberger, B.; Caspary, W.F.; Zeuzem, S.
BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability
Int. J. Colorectal Dis.
19
538-544
2004
Homo sapiens
Manually annotated by BRENDA team
Offman, J.; Gascoigne, K.; Bristow, F.; Macpherson, P.; Bignami, M.; Casorelli, I.; Leone, G.; Pagano, L.; Sica, S.; Halil, O.; Cummins, D.; Banner, N.R.; Karran, P.
Repeated sequences in CASPASE-5 and FANCD2 but not NF1 are targets for mutation in microsatellite-unstable acute leukemia/myelodysplastic syndrome
Mol. Cancer Res.
3
251-260
2005
Homo sapiens
Manually annotated by BRENDA team
Gao, J.; Wells, J.A.
Identification of specific tethered inhibitors for caspase-5
Chem. Biol. Drug Des.
79
209-215
2012
Homo sapiens
Manually annotated by BRENDA team
Bian, Z.M.; Elner, S.G.; Khanna, H.; Murga-Zamalloa, C.A.; Patil, S.; Elner, V.M.
Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells
Invest. Ophthalmol. Vis. Sci.
52
8646-8656
2011
Homo sapiens
Manually annotated by BRENDA team
Lopez, D.; Jimenez, M.; Garcia-Calvo, M.; Del Val, M.
Concerted antigen processing of a short viral antigen by human caspase-5 and -10
J. Biol. Chem.
286
16910-16913
2011
Homo sapiens
Manually annotated by BRENDA team
Bitto, N.J.; Baker, P.J.; Dowling, J.K.; Wray-McCann, G.; De Paoli, A.; Tran, L.S.; Leung, P.L.; Stacey, K.J.; Mansell, A.; Masters, S.L.; Ferrero, R.L.
Membrane vesicles from Pseudomonas aeruginosa activate the noncanonical inflammasome through caspase-5 in human monocytes
Immunol. Cell Biol.
96
1120-1130
2018
Homo sapiens (P51878), Homo sapiens
Manually annotated by BRENDA team
Vigano, E.; Diamond, C.E.; Spreafico, R.; Balachander, A.; Sobota, R.M.; Mortellaro, A.
Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes
Nat. Commun.
6
8761
2015
Homo sapiens (P51878), Homo sapiens
Manually annotated by BRENDA team
Hattinger, E.; Wolf, R.
Caspase-5 rescues UVB-dependent IL-1beta activity in ASC-deficient epidermal keratinocytes
Photodermatol. Photoimmunol. Photomed.
32
165-167
2016
Homo sapiens (P51878)
Manually annotated by BRENDA team