3.4.22.58: caspase-5
This is an abbreviated version!
For detailed information about caspase-5, go to the full flat file.
Word Map on EC 3.4.22.58
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3.4.22.58
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inflammasome
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caspase-4
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pyroptosis
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gsdmd
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gasdermin
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nonpolyposis
- 3.4.22.58
- inflammasome
- caspase-4
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pyroptosis
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gsdmd
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gasdermin
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nonpolyposis
Reaction
strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/- but also cleaves at Asp-Glu-Val-Asp-/- =
Synonyms
C14.008, cas-5, caspase 5, caspase-5, caspase-5/a, caspase-5/b, ICE(rel)-III, ICErelIII/TY, ICH-3 protease, transcript Y, TY, TY protease
ECTree
3.4.22.58 caspase-5Advanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.22.58 - caspase-5
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-WEHD-7-amido-4-methylcoumarin + H2O
acetyl-WEHD + 7-amino-4-methylcoumarin
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optimal tetrapeptide recognition motif
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?
interleukin-1beta + H2O
?
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50 nM enzyme partly cleaves interleukin-1beta into the 28000 Da form and a very faint 17500 Da band can be detected, with other dilutions of TY no cleavage is detected
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?
MDIGAYPHFMPTNLAGDPY + H2O
AYPHFMPTNLA + AYPHFMPTNLAGD + DIGAYPHFMPTNLAG + IGAYPHFMPTNLAGD + MDIGAYPHFMPTNL + MDIGAYPHFMPTNLA + MDIGAYPHFMPTNLAGD + MDIGAYPHFMPTNLAGDP + Met + MDIG + Met-Asp + Tyr + Pro-Tyr + GDPY + DPY
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quantitative product mass spectrometric analysis, overview
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?
pro-caspase-5 + H2O
?
caspase-5 has protease activity on its own precursor
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?
succinyl-YVAD-7-amido-4-methylcoumarin + H2O
succinyl-YVAD + 7-amino-4-methylcoumarin
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?
additional information
?
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the enzyme fails to process the interleukin-1beta precursor, activity is dependent on the presence of a cysteine residue at position 245
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?
additional information
?
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very little efficiency on caspase-1 substrates
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?
additional information
?
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the enzyme cleaves the substrates in the order of increasing efficiency: p35, pro-caspase-3, CrmA
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?
additional information
?
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the preferred cleavage sequence is WEHD-/- or LEHD-/-
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?
additional information
?
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the preferred cleavage sequence is WEHD-/- or LEHD-/-
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?
additional information
?
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the enzyme is involved in cytokine activation
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?
additional information
?
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the enzyme is able to induce apoptosis when overexpressed in COS cells
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?
additional information
?
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the production of the enzyme induces the activation of an endogenous 32000 Da putative cysteine protease (CPP32) like caspase
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?
additional information
?
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Ich-3 may mediate apoptosis induced by granzyme B. Ich-3 does not process pro-interleukin-1beta directly but does promote pro-interleukin-1beta processing by ICE. Ich-3 may play a very important role in apoptosis and inflammatory responses and may be an upstream regulator of ICE
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?
