3.4.22.58: caspase-5

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For detailed information about caspase-5, go to the full flat file.

strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/- but also cleaves at Asp-Glu-Val-Asp-/- =

C14.008, cas-5, caspase 5, caspase-5, caspase-5/a, caspase-5/b, ICE(rel)-III, ICErelIII/TY, ICH-3 protease, transcript Y, TY, TY protease

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Results	in table
1	Activating Compound
2	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
131	Disease/ Diagnostics
2	Expression
6	General Information
18	Inhibitors
8	Ki Value [mM]
3	KM Value [mM]
2	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
18	Organism
2	pH Optimum
3	Posttranslational Modification
1	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reaction Type
18	Reference
14	Source Tissue
19	Substrates and Products (Substrate)
2	Subunits
14	Synonyms
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Cloned on EC 3.4.22.58 - caspase-5

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expression in 293-cells

overexpression in COS cells

overexpression in Escherichia coli, Rat-1 or HeLa cells

the enzyme is expressed in baculovirus-infected insect cells, as a 30000 Da protein lacking the propeptide