3.4.22.58: caspase-5
This is an abbreviated version!
For detailed information about caspase-5, go to the full flat file.
Word Map on EC 3.4.22.58
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3.4.22.58
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inflammasome
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caspase-4
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pyroptosis
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gsdmd
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gasdermin
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nonpolyposis
- 3.4.22.58
- inflammasome
- caspase-4
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pyroptosis
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gsdmd
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gasdermin
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nonpolyposis
Reaction
strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/- but also cleaves at Asp-Glu-Val-Asp-/- =
Synonyms
C14.008, cas-5, caspase 5, caspase-5, caspase-5/a, caspase-5/b, ICE(rel)-III, ICErelIII/TY, ICH-3 protease, transcript Y, TY, TY protease
ECTree
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General Information
General Information on EC 3.4.22.58 - caspase-5
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malfunction
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caspase-5 knockdown by shRNA reduces caspase-1 protein expression and activation and inhibited TNF-alphainduced interleukin-8 and MCP-1
physiological function
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caspase-5 is an initiator caspase of proinflammatory and apoptotic pathways induced by vaccinia infection. The processing of a short vaccinia virus-encoded antigen can take place by a proteasome-independent pathway involving initiator caspase-5 and -10, which generate antigenic peptides recognized by CD8+ T lymphocytes. Each enzyme can use the degradation products of the other as substrate for new cleavages, indicating concerted endoproteolytic activity of caspase-5 and -10, EC 3.4.22.58 and EC 3.4.22.63
physiological function
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functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells. Involvement of caspase-5 in tunicamycin-induced apoptotic cell death, similar to caspase-4, EC 3.4.22.57
physiological function
caspase-4 and caspase-5 are the key determinants of one-step inflammasome activation in human monocyte. The contribute to TLR4-mediated IL-1alpha/beta release from human monocytes
physiological function
caspase-5 rescues UVB-dependent IL-1beta activity in apoptosis-associated speck-like protein containing a CARD (ASC)-deficient epidermal keratinocyte
physiological function
membrane vesicles from Pseudomonas aeruginosa activate the noncanonical inflammasome in human monocytes through caspase-5