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Literature summary for 3.4.22.58 extracted from

  • Kamada, S.; Funahashi, Y.; Tsujimoto, Y.
    Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases (1997), Cell Death Differ., 4, 473-478.
    View publication on PubMed
Search for more literature for 3.4.22.58

Inhibitors

Inhibitors Comment Organism Structure
acetyl-YVAD-aldehyde no inhibition Homo sapiens
CrmA inhibits cleavage of pro-caspase-3 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens overexpression induces apoptosis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CrmA + H2O
-
 Homo sapiens ?
-
 ?
additional information the enzyme cleaves the substrates in the order of increasing efficiency: p35, pro-caspase-3, CrmA Homo sapiens ?
-
 ?
additional information overexpression induces apoptosis Homo sapiens ?
-
 ?
p35 + H2O
-
 Homo sapiens ?
-
 ?
pro-caspase-3 + H2O
-
 Homo sapiens p12 + pro-p17
-
 ?