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3.4.22.51: cruzipain

This is an abbreviated version!
For detailed information about cruzipain, go to the full flat file.

Word Map on EC 3.4.22.51

Reaction

broad endopeptidase specificity similar to that of cathepsin L =

Synonyms

brucipain, cathepsin L-like cysteine protease, cathepsin L-like protease, CatL-like protease, congopain, CP, cruzain, cruzipain, cruzipain 2, CTE-truncated recombinant protease, cz, CZP, evansain, family C1 cysteine peptidase, GP57/51, kinin-releasing cysteine proteases, lysosomal-like cysteine protease, major cysteine proteinase, major cysteine-protease, NACrI, proteinase, Trypanosoma congolese cysteine, proteinase, Trypanosoma cruzi cysteine, proteinase, Trypanosoma cysteine, rhodesain, TCI, TCII, trypanopain, Trypanosoma congolese cysteine protease, Trypanosoma cruzi cysteine protease, Trypanosoma cysteine protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.51 cruzipain

Crystallization

Crystallization on EC 3.4.22.51 - cruzipain

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
bound to benzoyl-Arg-Ala-fluoromethyl ketone and benzoyl-Tyr-Ala-fluoromethyl ketone, hanging drop vapor diffusion method
complexed with benzyloxycarbonyl-Phe-Ala-fluoromethylketone
cruzain crystals diffract to 1.2 A resolution, yielding two novel cruzain structures: apocruzain and cruzain bound to the reversible covalent inhibitor S-methyl thiomethanesulfonate. Mass-spectrometric experiments confirm the presence of a methylthiol group attached to the catalytic cysteine
enzyme lacking the C-terminal domain, complexed with benzyloxycarbonyl-Phe-Ala-fluoromethylketone
recombinant protein and truncated version