3.4.22.51: cruzipain

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For detailed information about cruzipain, go to the full flat file.

Reaction

broad endopeptidase specificity similar to that of cathepsin L =

Synonyms

brucipain, cathepsin L-like cysteine protease, cathepsin L-like protease, CatL-like protease, congopain, CP, cruzain, cruzipain, cruzipain 2, CTE-truncated recombinant protease, cz, CZP, evansain, family C1 cysteine peptidase, GP57/51, kinin-releasing cysteine proteases, lysosomal-like cysteine protease, major cysteine proteinase, major cysteine-protease, NACrI, proteinase, Trypanosoma congolese cysteine, proteinase, Trypanosoma cruzi cysteine, proteinase, Trypanosoma cysteine, rhodesain, TCI, TCII, trypanopain, Trypanosoma congolese cysteine protease, Trypanosoma cruzi cysteine protease, Trypanosoma cysteine protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.51 cruzipain

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Results	in table
8	Activating Compound
17	AA Sequence
7	Application
4	CAS Registry Number
10	Cloned(Commentary)
7	Crystallization (Commentary)
2	Expression
9	General Information
1	General Stability
109	IC50 Value
313	Inhibitors
31	kcat/KM [mM/s]
26	Ki Value [mM]
86	KM Value [mM]
13	Localization
1	Metals/Ions
13	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
107	Organism
47	PDB ID
25	pH Optimum
4	pH Range
6	pH Stability
9	Posttranslational Modification
5	Protein Variants
16	Purification (Commentary)
1	Reaction
4	Reaction Type
76	Reference
14	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
155	Substrates and Products (Substrate)
1	Subunits
73	Synonyms
13	Temperature Optimum [°C]
3	Temperature Stability [°C]
77	Turnover Number [1/s]

Metals Ions

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Metals Ions on EC 3.4.22.51 - cruzipain

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METALS and IONS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

NaCl

Trypanosoma cruzi

Q598P5

Km increases up to 400 mM, then decreases and remains constant at 50-60% up to 1 M, kcat maximum at 300 mM

638883