3.4.22.51: cruzipain
This is an abbreviated version!
For detailed information about cruzipain, go to the full flat file.
Word Map on EC 3.4.22.51
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3.4.22.51
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cathepsins
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brucei
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protozoan
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epimastigotes
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trypomastigotes
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trypanocidal
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trypanosomiasis
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trypanosomal
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papain
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proteinases
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amastigote
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papain-like
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benznidazole
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anti-trypanosoma
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antiparasitic
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latin
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thiosemicarbazone
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vinyl
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rhodesiense
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cystatins
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nitril
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trypanothione
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nifurtimox
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antichagasic
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chagasin
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bauhinia
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kininogens
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warhead
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metacyclic
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medicine
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metacyclogenesis
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falcipain-2
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congolense
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cruzi-infected
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trans-sialidase
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tulahuen
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reservosomes
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n-acylhydrazones
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pharmacology
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molecular biology
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z-phe-arg-amc
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semicarbazone
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drug development
- 3.4.22.51
- cathepsins
- brucei
-
protozoan
- epimastigotes
- trypomastigotes
-
trypanocidal
- trypanosomiasis
-
trypanosomal
- papain
- proteinases
- amastigote
-
papain-like
- benznidazole
-
anti-trypanosoma
-
antiparasitic
-
latin
- thiosemicarbazone
-
vinyl
- rhodesiense
- cystatins
-
nitril
- trypanothione
- nifurtimox
-
antichagasic
- chagasin
- bauhinia
- kininogens
-
warhead
-
metacyclic
- medicine
-
metacyclogenesis
- falcipain-2
- congolense
-
cruzi-infected
- trans-sialidase
-
tulahuen
-
reservosomes
-
n-acylhydrazones
- pharmacology
- molecular biology
- z-phe-arg-amc
- semicarbazone
- drug development
Reaction
broad endopeptidase specificity similar to that of cathepsin L =
Synonyms
brucipain, cathepsin L-like cysteine protease, cathepsin L-like protease, CatL-like protease, congopain, CP, cruzain, cruzipain, cruzipain 2, CTE-truncated recombinant protease, cz, CZP, evansain, family C1 cysteine peptidase, GP57/51, kinin-releasing cysteine proteases, lysosomal-like cysteine protease, major cysteine proteinase, major cysteine-protease, NACrI, proteinase, Trypanosoma congolese cysteine, proteinase, Trypanosoma cruzi cysteine, proteinase, Trypanosoma cysteine, rhodesain, TCI, TCII, trypanopain, Trypanosoma congolese cysteine protease, Trypanosoma cruzi cysteine protease, Trypanosoma cysteine protease
ECTree
3.4.22.51 cruzipainAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.22.51 - cruzipain
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Gelatin + H2O
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?
additional information
?
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enzyme may be involved in facilitating parasite entry into the brain
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?
additional information
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enzyme may be involved in facilitating parasite entry into the brain
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?
additional information
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antigenic character in natural human infections
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?
additional information
?
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antigenic character in natural human infections
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?
additional information
?
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stimulates potent humoral and cellular immune response during infection in both humans and mice
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?
additional information
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stimulates potent humoral and cellular immune response during infection in both humans and mice
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?
additional information
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enzyme plays a role in the production of antibodies against cardiac M2 muscarinic acetylcholine receptor
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?
additional information
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enzyme plays a role in the production of antibodies against cardiac M2 muscarinic acetylcholine receptor
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?
additional information
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cruzipain may act as a survival factor for cardiomyocytes because it rescues them from apoptosis and stimulates arginase-2
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?
additional information
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design of selective prodrugs of primaquine: Lys-Arg-primaquine, Phe-Ala-primaquine, and Phe-Arg-primaquine, cleaved by the enzyme in vivo and selectively inhibiting it, overview
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