3.4.22.51: cruzipain

This is an abbreviated version!
For detailed information about cruzipain, go to the full flat file.

Word Map on EC 3.4.22.51

3.4.22.51

cathepsins

brucei

protozoan

epimastigotes

trypomastigotes

trypanocidal

trypanosomiasis

trypanosomal

papain

proteinases

amastigote

papain-like

benznidazole

anti-trypanosoma

antiparasitic

latin

thiosemicarbazone

vinyl

rhodesiense

cystatins

nitril

trypanothione

nifurtimox

antichagasic

chagasin

bauhinia

kininogens

warhead

metacyclic

medicine

metacyclogenesis

falcipain-2

congolense

cruzi-infected

trans-sialidase

tulahuen

reservosomes

n-acylhydrazones

pharmacology

molecular biology

z-phe-arg-amc

semicarbazone

drug development

Reaction

broad endopeptidase specificity similar to that of cathepsin L =

Synonyms

brucipain, cathepsin L-like cysteine protease, cathepsin L-like protease, CatL-like protease, congopain, CP, cruzain, cruzipain, cruzipain 2, CTE-truncated recombinant protease, cz, CZP, evansain, family C1 cysteine peptidase, GP57/51, kinin-releasing cysteine proteases, lysosomal-like cysteine protease, major cysteine proteinase, major cysteine-protease, NACrI, proteinase, Trypanosoma congolese cysteine, proteinase, Trypanosoma cruzi cysteine, proteinase, Trypanosoma cysteine, rhodesain, TCI, TCII, trypanopain, Trypanosoma congolese cysteine protease, Trypanosoma cruzi cysteine protease, Trypanosoma cysteine protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.51 cruzipain

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Results	in table
8	Activating Compound
17	AA Sequence
7	Application
4	CAS Registry Number
10	Cloned(Commentary)
7	Crystallization (Commentary)
2	Expression
9	General Information
1	General Stability
109	IC50 Value
313	Inhibitors
31	kcat/KM [mM/s]
26	Ki Value [mM]
86	KM Value [mM]
13	Localization
1	Metals/Ions
13	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
107	Organism
47	PDB ID
25	pH Optimum
4	pH Range
6	pH Stability
9	Posttranslational Modification
5	Protein Variants
16	Purification (Commentary)
1	Reaction
4	Reaction Type
76	Reference
14	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
155	Substrates and Products (Substrate)
1	Subunits
73	Synonyms
13	Temperature Optimum [°C]
3	Temperature Stability [°C]
77	Turnover Number [1/s]

Localization

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Localization on EC 3.4.22.51 - cruzipain

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cell surface

Trypanosoma cruzi

the signaling factor NF-kB P65 colocalizes with cruzain on the cell surface of intracellular wild-type parasites