3.4.21.B12: prostase
This is an abbreviated version!
For detailed information about prostase, go to the full flat file.
Word Map on EC 3.4.21.B12
-
3.4.21.B12
-
klk4
-
kallikreins
-
amelogenins
-
amelogenesis
-
ameloblastin
-
enamelysin
-
incisor
-
imperfecta
-
maturation-stage
-
amelx
-
amelotin
-
medicine
-
secretory-stage
-
hypomineralized
-
masp-1
-
hypomaturation
-
crystallite
-
metalloproteinase-20
-
analysis
-
diagnostics
- 3.4.21.B12
- klk4
- kallikreins
- amelogenins
-
amelogenesis
- ameloblastin
- enamelysin
- incisor
- imperfecta
-
maturation-stage
-
amelx
-
amelotin
- medicine
-
secretory-stage
-
hypomineralized
- masp-1
-
hypomaturation
-
crystallite
-
metalloproteinase-20
- analysis
- diagnostics
Reaction
proteolysis of polypeptides =
Synonyms
EM serine proteinase 1, EMSP1, enamel matrix serine protease 1, HK4, K4, kallikrein 1-related peptidase 4, kallikrein 4, kallikrein-4, kallikrein-4 proteinase, kallikrein-like protein 1, kallikrein-related peptidase, kallikrein-related peptidase 4, kallikrein-related peptidase-4, KLK, KLK-4 proteinase, KLK-L1, KLK4, More, peptidase S01.251, prostase, prostate cancer serine protease, PRSS17, S01.251, serine protease 1, serine protease 17, tissue kallikrein-related peptidase 4
ECTree
Advanced search results
Engineering
Engineering on EC 3.4.21.B12 - prostase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
E77A
H25A
additional information
-
naturally occuring gene mutation G214A results in a truncated enzyme that lacks residue S207 of the catalytic triad. Mutation affects tooth enamel formation causing the enamel crystallites to grow incompletely in thickness or width but to normal length, i.e. autosomal recessive hypomaturation amelogenesis imperfecta
additional information
-
KLK-4 mutant (g.2142G>A), enamel is of normal thickness but opaque throughout its width compared with normal enamel. Enamel has a normal prismatic structure and generally a well-organized and discernable crystallite composition. In some areas, globular structures are present where crystallites are not discernable or appear to have an altered morphology. The KLK-4 mutant enamel has an increased protein content compared with normal enamel