3.4.21.B12: prostase
This is an abbreviated version!
For detailed information about prostase, go to the full flat file.
Word Map on EC 3.4.21.B12
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3.4.21.B12
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klk4
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kallikreins
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amelogenins
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amelogenesis
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ameloblastin
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enamelysin
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incisor
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imperfecta
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maturation-stage
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amelx
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amelotin
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medicine
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secretory-stage
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hypomineralized
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masp-1
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hypomaturation
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crystallite
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metalloproteinase-20
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analysis
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diagnostics
- 3.4.21.B12
- klk4
- kallikreins
- amelogenins
-
amelogenesis
- ameloblastin
- enamelysin
- incisor
- imperfecta
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maturation-stage
-
amelx
-
amelotin
- medicine
-
secretory-stage
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hypomineralized
- masp-1
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hypomaturation
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crystallite
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metalloproteinase-20
- analysis
- diagnostics
Reaction
proteolysis of polypeptides =
Synonyms
EM serine proteinase 1, EMSP1, enamel matrix serine protease 1, HK4, K4, kallikrein 1-related peptidase 4, kallikrein 4, kallikrein-4, kallikrein-4 proteinase, kallikrein-like protein 1, kallikrein-related peptidase, kallikrein-related peptidase 4, kallikrein-related peptidase-4, KLK, KLK-4 proteinase, KLK-L1, KLK4, More, peptidase S01.251, prostase, prostate cancer serine protease, PRSS17, S01.251, serine protease 1, serine protease 17, tissue kallikrein-related peptidase 4
ECTree
3.4.21.B12 prostaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.21.B12 - prostase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
52 kDa prostatic acid phosphatase + H2O
33 kDa prostatic acid phosphatase + 19 kDa fragment
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enzyme may be involved in the physiological clearance of prostatic acid phosphatase
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?
amelogenin + H2O
?
the enzyme plays a pivotal role during dental enamel formation by degrading the major enamel protein, amelogenin, prior to the final steps of enamel hardening. KLK4 self-destructs once amelogenin is degraded. It progressively loses activity, becomes aggregated, and autofragmented when incubated without substrate in both the presence and absence of reducer. However, with non-ionic detergent present as proxy substrate, KLK4 remains active and intact throughout
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?
matrix metalloproteinase-1 + H2O
?
the enzyme activates matrix metalloproteinase-1, a protease that promotes prostate tumor growth and metastasis. Matrix metalloproteinase-1 is produced in the tumor compartment of prostate cancer bone metastases, highlighting its accessibility to KLK4 at this site
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?
plasma hepatocyte growth factor activator zymogen + H2O
mature HGF activator + ?
activation, hepatocyte growth factor is mainly secreted from fibroblasts as an inactive single-chain precursor, which lacks biological activity
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?
protease-activated receptor-1 + H2O
?
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KLK4 cleaves protease-activated receptor-1 at the activation site on intact cell surface
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?
thrombospondin-1 + H2O
?
the enzyme liberates an N-terminal product, with purported angiogenic activity, from thrombospondin-1. It cleaves thrombospondin-1 in osteoblast-derived matrix
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?
polypeptide + H2O
peptides
enzyme is involved in degradation of extracellular matrix and activation of prostate specific antigen PSA and other proteases
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?
polypeptide + H2O
peptides
enzyme is regulated by steroid hormones
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?
polypeptide + H2O
peptides
enzyme may be involved in the pathogenesis and/or progression of prostate, breast, and possibly other malgnancies
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?
polypeptide + H2O
peptides
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enzyme plays a role in the physiologic processing of seminal plasma proteins , e.g. pro-PSA, as well as in the pathogenesis of prostate cancer through the activation of pro-PSA
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?
pro-prostate-specific antigen + H2O
activated prostate-specific antigen
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i.e. PSA
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?
pro-prostate-specific antigen + H2O
activated prostate-specific antigen
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activation of PSA
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?
additional information
?
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enzyme is regulated by steroid hormones, contains androgen response elements in the proximal promotor region
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?
additional information
?
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enzyme is involved in tissue remodeling and cancer metastasis
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?
additional information
?
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enzyme modulates the tumor-associated urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor system activity by either activating the pro-enzyme form of urokinase-type plasminogen activator or cleaving the cell surface-associated urokinase-type plasminogen activator receptor
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?
additional information
?
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kallikrein-4 is a serine protease expressed during enamel maturation, and proteolytic processing of the enamel matrix by KLK4 is critical for proper enamel formation. In vitro dipeptidyl peptidase I activates pro-KLK4 to cleave a fluorogenic peptide containing a KLK4 cleavage site
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?
additional information
?
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the enzyme performs proteolytic autoactivation
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?
additional information
?
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the enzyme performs proteolytic autoactivation
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?
additional information
?
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enzyme participates in the degradation of enamel proteins in vivo
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?
additional information
?
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enzyme participates in the degradation of enamel proteins in vivo
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?
