3.4.21.B12: prostase

This is an abbreviated version!
For detailed information about prostase, go to the full flat file.

Reaction

proteolysis of polypeptides =

Synonyms

EM serine proteinase 1, EMSP1, enamel matrix serine protease 1, HK4, K4, kallikrein 1-related peptidase 4, kallikrein 4, kallikrein-4, kallikrein-4 proteinase, kallikrein-like protein 1, kallikrein-related peptidase, kallikrein-related peptidase 4, kallikrein-related peptidase-4, KLK, KLK-4 proteinase, KLK-L1, KLK4, More, peptidase S01.251, prostase, prostate cancer serine protease, PRSS17, S01.251, serine protease 1, serine protease 17, tissue kallikrein-related peptidase 4

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B12 prostase

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10	Activating Compound
4	AA Sequence
15	Application
2	CAS Registry Number
20	Cloned(Commentary)
2	Crystallization (Commentary)
255	Disease/ Diagnostics
1	Expression
9	General Information
4	IC50 Value
12	Inhibitors
7	KM Value [mM]
13	Localization
10	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
43	Organism
6	pH Optimum
1	pH Range
1	pI Value
10	Posttranslational Modification
6	Protein Variants
10	Purification (Commentary)
10	Reaction
1	Reaction Type
42	Reference
2	Renatured (Commentary)
92	Source Tissue
4	Specific Activity [micromol/min/mg]
1	Storage Stability
92	Substrates and Products (Substrate)
8	Subunits
71	Synonyms
3	Temperature Optimum [°C]
6	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.21.B12 - prostase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

by vapor diffusion in hanging drops. K4 crystallised in the presence of 10 mM Ni2+ reveals tetragonal space group P4. In the presence of Zn2+ it reveals tetragonal space group P41212. In the presence of 10 mM Co2+ it reveals monoclinic space group P21. The three different K4 crystal forms with bound Ni2+, Zn2, and Co2+ contain two, four and 16 crystallographically independent K4 molecules per asymmetric unit, respectively. K4 possesses an unusual 99-loop that creates a groove-like acidic S2 subsite

Homo sapiens

-

681390

hanging drop vapour diffusion method using 20% PEG-MME 2000, 100 mM Tris (pH 8.5) and 10 mM NiCl2, or 100 mM HEPES (pH 6.5) and 100 mM NaCl with 1.6 M ammonium sulfate, or with 10 mM CoCl2, 100 mM Mes buffer (pH 6.0) and 1.6 M ammonium sulfate

Homo sapiens

-

681390