3.4.21.B1: hyaluronan-binding serine protease

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For detailed information about hyaluronan-binding serine protease, go to the full flat file.

Reaction

endopeptidase activity. Cleaves C-terminal site of Lys and Arg =

Synonyms

factor seven activating protease, factor VII activating protease, factor VII-activating protease, FASP, FSAP, gelatinolytic serine proteinase, HABP, HABP2, hyaluronan binding protein 2, hyaluronan-binding protease, hyaluronic acid-binding protease, PHBP, PHBSP, plasma hyaluronan-binding protein, S01.033

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B1 hyaluronan-binding serine protease

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Results	in table
33	Activating Compound
2	AA Sequence
10	Application
1	CAS Registry Number
5	Cloned(Commentary)
333	Disease/ Diagnostics
2	Expression
11	General Information
52	Inhibitors
1	Ki Value [mM]
2	KM Value [mM]
1	Localization
3	Metals/Ions
29	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
38	Organism
2	pH Optimum
2	pI Value
5	Posttranslational Modification
7	Protein Variants
11	Purification (Commentary)
1	Reaction
26	Reaction Type
38	Reference
1	Renatured (Commentary)
57	Source Tissue
1	Specific Activity [micromol/min/mg]
99	Substrates and Products (Substrate)
8	Subunits
58	Synonyms
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Expression

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Expression on EC 3.4.21.B1 - hyaluronan-binding serine protease

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

in late pregnancy the plasma FSAP antigen and activity is significantly higher compared with levels in non-pregnant women and remains elevated after delivery, plasma FSAP levels in women using oral contraceptives are also significantly elevated compared to the control group. FSAP mRNA levels are strongly induced by estradiol in monocytes but not in hepatocytes

Homo sapiens

-

710611

oral contraceptive use with preparartions containing ethinylestradiol, levonorgestrel, desogestrel, gestodene, and norgestimate increases the plasma measures of factor VII-activating protease

Homo sapiens

-

718425