3.4.21.B1: hyaluronan-binding serine protease
This is an abbreviated version!
For detailed information about hyaluronan-binding serine protease, go to the full flat file.
Word Map on EC 3.4.21.B1
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3.4.21.B1
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marburg
-
fibrinolysis
-
haemostasis
-
nonmedullary
-
autoactivation
-
pro-urokinase
-
fnmtc
-
medicine
-
srgap1
-
analysis
- 3.4.21.B1
-
marburg
-
fibrinolysis
-
haemostasis
-
nonmedullary
-
autoactivation
- pro-urokinase
-
fnmtc
- medicine
-
srgap1
- analysis
Reaction
endopeptidase activity. Cleaves C-terminal site of Lys and Arg =
Synonyms
factor seven activating protease, factor VII activating protease, factor VII-activating protease, FASP, FSAP, gelatinolytic serine proteinase, HABP, HABP2, hyaluronan binding protein 2, hyaluronan-binding protease, hyaluronic acid-binding protease, PHBP, PHBSP, plasma hyaluronan-binding protein, S01.033
ECTree
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Reference on EC 3.4.21.B1 - hyaluronan-binding serine protease
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Etscheid, M.; Hunfeld, A.; Konig, H.; Seitz, R.; Dodt, J.
Activation of proPHBSP, the zymogen of a plasma hyaluronan binding serine protease, by an intermolecular autocatalytic mechanism
Biol. Chem.
381
1223-1231
2000
Homo sapiens
Romisch, J.
Factor VII activating protease (FSAP): a novel protease in hemostasis
Biol. Chem.
383
1119-1124
2002
Homo sapiens
Etscheid, M.; Beer, N.; Fink, E.; Seitz, R.; Johannes, D.
The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin
Biol. Chem.
383
1633-1643
2002
Homo sapiens
Choi-Miura, N.H.; Yoda, M.; Saito, K.; Takahashi, K.; Tomita, M.
Identification of the substrates for plasma hyaluronan binding protein
Biol. Pharm. Bull.
24
140-143
2001
Homo sapiens
Choi-Miura, N.H.; Saito, K.; Takahashi, K.; Yoda, M.; Tomita, M.
Regulation mechanism of the serine protease activity of plasma hyaluronan binding protein
Biol. Pharm. Bull.
24
221-225
2001
Homo sapiens
Choi-Miura, N.H.; Takahashi, K.; Yoda, M.; Saito, K.; Mazda, T.; Tomita, M.
Proteolytic activation and inactivation of the serine protease activity of plasma hyaluronan binding protein
Biol. Pharm. Bull.
24
448-452
2001
Homo sapiens
Kannemeier, C.; Feussner, A.; Stohr, H.A.; Weisse, J.; Preissner, K.T.; Romisch, J.
Factor VII and single-chain plasminogen activator-activating protease: activation and autoactivation of the proenzyme
Eur. J. Biochem.
268
3789-3796
2001
Homo sapiens
Hunfeld, A.; Etscheid, M.; Konig, H.; Seitz, R.; Dodt, J.
Detection of a novel plasma serine protease during purification of vitamin K-dependent coagulation factors
FEBS Lett.
456
290-294
1999
Homo sapiens (Q14520), Homo sapiens
Vostrov, A.A.; Quitschke, W.W.
Plasma hyaluronan-binding protein is a serine protease
J. Biol. Chem.
275
22978-22985
2000
Bos taurus, Oryctolagus cuniculus, Equus sp., Homo sapiens
Etscheid, M.; Beer, N.; Dodt, J.
The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration
Cell. Signal.
17
1486-1494
2005
Homo sapiens
Choi-Miura, N.H.
Novel human plasma proteins, IHRP (acute phase protein) and PHBP (serine protease), which bind to glycosaminoglycans
Curr. Med. Chem. Cardiovasc. Hematol. Agents
2
239-248
2004
Homo sapiens
Parahuleva, M.S.; Kanse, S.M.; Parviz, B.; Barth, A.; Tillmanns, H.; Bohle, R.M.; Sedding, D.G.; Hoelschermann, H.
Factor Seven Activating Protease (FSAP) expression in human monocytes and accumulation in unstable coronary atherosclerotic plaques
Atherosclerosis
196
164-171
2008
Homo sapiens
Muhl, L.; Nykjaer, A.; Wygrecka, M.; Monard, D.; Preissner, K.T.; Kanse, S.M.
Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP-inhibitor complexes are internalized via LRP
Biochem. J.
404
191-196
2007
Homo sapiens
Shibamiya, A.; Muhl, L.; Tannert-Otto, S.; Preissner, K.T.; Kanse, S.M.
Nucleic acids potentiate Factor VII-activating protease (FSAP)-mediated cleavage of platelet-derived growth factor-BB and inhibition of vascular smooth muscle cell proliferation
Biochem. J.
404
45-50
2007
Homo sapiens
Kress, J.A.; Seitz, R.; Dodt, J.; Etscheid, M.
Induction of intracellular signalling in human endothelial cells by the hyaluronan-binding protease involves two distinct pathways
Biol. Chem.
387
1275-1283
2006
Homo sapiens
Etscheid, M.; Kress, J.; Seitz, R.; Dodt, J.
The hyaluronic acid-binding protease: a novel vascular and inflammatory mediator?
Int. Immunopharmacol.
8
166-170
2008
Homo sapiens
Wygrecka, M.; Morty, R.E.; Markart, P.; Kanse, S.M.; Andreasen, P.A.; Wind, T.; Guenther, A.; Preissner, K.T.
Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome
J. Biol. Chem.
282
21671-21682
2007
Homo sapiens
Kanse, S.M.; Parahuleva, M.; Muhl, L.; Kemkes-Matthes, B.; Sedding, D.; Preissner, K.T.
Factor VII-activating protease (FSAP): vascular functions and role in atherosclerosis
Thromb. Haemost.
99
286-289
2008
Homo sapiens
Stephan, S.; Schwarz, H.; Borchert, A.; Bussfeld, D.; Quak, E.; Simshaeuser-Knaub, B.; Teigelkamp, S.; Behrens, F.; Vitzthum, F.
Tests for the measurement of factor VII-activating protease (FSAP) activity and antigen levels in citrated plasma, their correlation to PCR testing, and utility for the detection of the Marburg I-polymorphism of FSAP
Clin. Chem. Lab. Med.
46
1109-1116
2008
Homo sapiens (Q14520)
Muhl, L.; Hersemeyer, K.; Preissner, K.T.; Weimer, T.; Kanse, S.M.
Structure-function analysis of factor VII activating protease (FSAP): sequence determinants for heparin binding and cellular functions
FEBS Lett.
583
1994-1998
2009
Homo sapiens (Q14520)
Wasmuth, H.E.; Tag, C.G.; Van de Leur, E.; Hellerbrand, C.; Mueller, T.; Berg, T.; Puhl, G.; Neuhaus, P.; Samuel, D.; Trautwein, C.; Kanse, S.M.; Weiskirchen, R.
The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB
Hepatology
49
775-780
2009
Homo sapiens (Q14520), Homo sapiens
Parahuleva, M.S.; Hoelschermann, H.; Erdogan, A.; Langanke, E.; Prickartz, I.; Parviz, B.; Weiskirchen, R.; Tillmanns, H.; Kanse, S.M.
Factor Seven Activating Protease (FSAP) levels during normal pregnancy and in women using oral contraceptives
Thromb. Res.
126
e36-e40
2010
Homo sapiens
Kanse, S.M.; Declerck, P.J.; Ruf, W.; Broze, G.; Etscheid, M.
Factor VII-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor
Arterioscler. Thromb. Vasc. Biol.
32
427-433
2012
Homo sapiens
Yamamichi, S.; Fujiwara, Y.; Kikuchi, T.; Nishitani, M.; Matsushita, Y.; Hasumi, K.
Extracellular histone induces plasma hyaluronan-binding protein (factor VII activating protease) activation in vivo
Biochem. Biophys. Res. Commun.
409
483-488
2011
Mus musculus
Yamamoto, E.; Nishimura, N.; Okada, K.; Sekido, C.; Yamamichi, S.; Hasumi, K.
Inhibitors of autoactivation of plasma hyaluronan-binding protein (factor VII activating protease)
Biol. Pharm. Bull.
34
462-470
2011
Homo sapiens
Sidelmann, J.J.; Skouby, S.O.; Kluft, C.; Winkler, U.; Vitzthum, F.; Schwarz, H.; Gram, J.; Jespersen, J.
Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo
Thromb. Res.
128
e67-e72
2011
Homo sapiens
Yoshida, A.; Wang, Y.; Bae, I.; Cao, M.J.; Osatomi, K.; Hara, K.
Molecular cloning and tissue distribution of hyaluronan binding protein 2 (HABP2) in red sea bream Pagrus major
Comp. Biochem. Physiol. B
165
271-276
2013
Pagrus major (S6B5D3), Pagrus major
Sperling, C.; Maitz, M.F.; Grasso, S.; Werner, C.; Kanse, S.M.
A positively charged surface triggers coagulation activation through factor VII activating protease (FSAP)
ACS Appl. Mater. Interfaces
9
40107-40116
2017
Homo sapiens (Q14520)
Byskov, K.; Boettger, T.; Ruehle, P.F.; Nielsen, N.V.; Etscheid, M.; Kanse, S.M.
Factor VII activating protease (FSAP) regulates the expression of inflammatory genes in vascular smooth muscle and endothelial cells
Atherosclerosis
265
133-139
2017
Homo sapiens (Q14520), Homo sapiens
Etscheid, M.; Subramaniam, S.; Lochnit, G.; Zabczyk, M.; Undas, A.; Lang, I.M.; Hanschmann, K.M.; Kanse, S.M.
Altered structure and function of fibrinogen after cleavage by Factor VII Activating Protease (FSAP)
Biochim. Biophys. Acta Mol. Basis Dis.
1864
3397-3406
2018
Homo sapiens (Q14520), Homo sapiens
Ramanathan, R.; Gram, J.B.; Sand, N.P.R.; Norgaard, B.L.; Diederichsen, A.C.P.; Vitzthum, F.; Schwarz, H.; Sidelmann, J.J.
Factor VII-activating protease sex-related association with coronary artery calcification
Blood Coagul. Fibrinolysis
28
558-563
2017
Homo sapiens (Q14520), Homo sapiens
Mirzapoiazova, T.; Mambetsariev, N.; Lennon, F.E.; Mambetsariev, B.; Berlind, J.E.; Salgia, R.; Singleton, P.A.
HABP2 is a novel regulator of hyaluronan-mediated human lung cancer progression
Front. Oncol.
5
164
2015
Homo sapiens (Q14520), Homo sapiens
de Jong, H.K.; Koh, G.C.; Bulder, I.; Stephan, F.; Wiersinga, W.J.; Zeerleder, S.S.
Diabetes-independent increase of factor VII-activating protease activation in patients with Gram-negative sepsis (melioidosis)
J. Thromb. Haemost.
13
41-6
2015
Homo sapiens (Q14520)
Kara, E.; Manna, D.; Loeset, G..; Schneider, E.L.; Craik, C.S; Kanse, S.
Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates
Thromb. Haemost.
117
1750-1760
2017
Homo sapiens (Q14520)
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