3.4.21.B1: hyaluronan-binding serine protease

This is an abbreviated version!
For detailed information about hyaluronan-binding serine protease, go to the full flat file.

Word Map on EC 3.4.21.B1

3.4.21.B1

marburg

fibrinolysis

haemostasis

nonmedullary

autoactivation

pro-urokinase

fnmtc

medicine

srgap1

analysis

Reaction

endopeptidase activity. Cleaves C-terminal site of Lys and Arg =

Synonyms

factor seven activating protease, factor VII activating protease, factor VII-activating protease, FASP, FSAP, gelatinolytic serine proteinase, HABP, HABP2, hyaluronan binding protein 2, hyaluronan-binding protease, hyaluronic acid-binding protease, PHBP, PHBSP, plasma hyaluronan-binding protein, S01.033

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.B1 hyaluronan-binding serine protease

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Results	in table
33	Activating Compound
2	AA Sequence
10	Application
1	CAS Registry Number
5	Cloned(Commentary)
333	Disease/ Diagnostics
2	Expression
11	General Information
52	Inhibitors
1	Ki Value [mM]
2	KM Value [mM]
1	Localization
3	Metals/Ions
29	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
38	Organism
2	pH Optimum
2	pI Value
5	Posttranslational Modification
7	Protein Variants
11	Purification (Commentary)
1	Reaction
26	Reaction Type
38	Reference
1	Renatured (Commentary)
57	Source Tissue
1	Specific Activity [micromol/min/mg]
99	Substrates and Products (Substrate)
8	Subunits
58	Synonyms
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Activating Compound

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Activating Compound on EC 3.4.21.B1 - hyaluronan-binding serine protease

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chondroitin sulfate

Homo sapiens

increases kininogen cleavage at above 1 mg/ml

Dextran sulfate

heparan sulfate

heparin

histone

histones H1, H2A, H2B, H3, and H4 promote pro-plasma hyaluronan-binding protein autoactivation in vivo. Histones do not affect enzymatic activity of the active form of plasma hyaluronan-binding protein

717196

hyaluronic acid

Homo sapiens

activates single-chain inactivate zymogen to the two-chain active enzyme

690121

IL-6

Homo sapiens

stimulates FSAP mRNA expression 5.5fold at 24 h

684801

IL-8

Homo sapiens

can stimulate the expression of HABP mRNA in lung microvascular endothelial cells and in bronchial epithelial cells

687108

IL-alpha

Homo sapiens

stimulates FSAP mRNA expression 4fold at 24 h

684801

LPS

Homo sapiens

stimulates FSAP mRNA expression 6fold after 1 h, reaching a plateau at 2 h (7fold stimulation) and gradually decreases until returning to the base level at 24 h

684801

phosphatidylethanolamine

Homo sapiens

enhances autofragmentation and serine protease activity at 0.001 mg/ml and 0.00001 mg/ml

poly-L-lysine

polyethylenimine

FSAP is exclusively activated by the positively charged surfaces polyethylenimine and poly-L-lysine

RNA

UpA

urokinase

potential physiological activator

650458

additional information

2 entries