3.4.21.73: u-Plasminogen activator
This is an abbreviated version!
For detailed information about u-Plasminogen activator, go to the full flat file.
Word Map on EC 3.4.21.73
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3.4.21.73
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fibrinolytic
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pai-1
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artery
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metastasis
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thrombolysis
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tissue-type
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fibrin
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endothelial
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clot
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vein
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inhibitor-1
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infarct
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heparin
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streptokinase
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thrombus
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catheter
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venous
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myocardial
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fibrinogen
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embolism
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coronary
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bleeding
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angiogenesis
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hemorrhage
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coagulation
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anticoagulation
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single-chain
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zymography
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mmp-9
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metalloproteinases
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angioplasty
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patency
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angiography
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recanalization
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percutaneous
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thrombotic
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thromboembolism
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vitronectin
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occlusions
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kringle
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intraarterial
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pericellular
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transluminal
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intracoronary
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thrombectomy
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amidolytic
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2-antiplasmin
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euglobulin
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alteplase
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reocclusion
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drug development
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pharmacology
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analysis
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agriculture
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diagnostics
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medicine
- 3.4.21.73
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fibrinolytic
- pai-1
- artery
- metastasis
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thrombolysis
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tissue-type
- fibrin
- endothelial
- clot
- vein
- inhibitor-1
- infarct
- heparin
- streptokinase
- thrombus
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catheter
- venous
- myocardial
- fibrinogen
- embolism
- coronary
- bleeding
- angiogenesis
- hemorrhage
- coagulation
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anticoagulation
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single-chain
-
zymography
- mmp-9
- metalloproteinases
-
angioplasty
-
patency
-
angiography
-
recanalization
-
percutaneous
-
thrombotic
- thromboembolism
- vitronectin
- occlusions
-
kringle
-
intraarterial
-
pericellular
-
transluminal
-
intracoronary
-
thrombectomy
-
amidolytic
-
2-antiplasmin
-
euglobulin
- alteplase
-
reocclusion
- drug development
- pharmacology
- analysis
- agriculture
- diagnostics
- medicine
Reaction
Specific cleavage of Arg-/-Val bond in plasminogen to form plasmin =
Synonyms
Abbokinase, Cellular plasminogen activator, Double-chain urokinase-type plasminogen activator, EC 3.4.21.31, EC 3.4.99.26, Plasminogen activator, urokinase-type, PLAU, Two-chain urokinase-type plasminogen activator, u-PA, U-plasminogen activator, UK, uPA, uPA-type Plg activator, Urinary esterase A, Urinary plasminogen activator, Urokinase, Urokinase plasminogen activator, urokinase type plasminogen activator, urokinase-plasminogen activator, urokinase-type PA, urokinase-type plasmin activator, urokinase-type plasminogen, Urokinase-type plasminogen activator, urokinase-type Plg activator, urokine-type plasminogen activator
ECTree
3.4.21.73 u-Plasminogen activatorAdvanced search results
results (
results (Activating Compound
Activating Compound on EC 3.4.21.73 - u-Plasminogen activator
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
1,3,8-trihydroxy-6-methylanthraquinone
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i.e. emodin, an active compound of aloe. Emodin increases the fibrinolytic activity of fibroblast cells in a dose-dependent manner, linked to increased uPA activity and uPA gene up-regulation. Emodin also induces up-regulation of uPA inhibitor PAI-1. Up-regulations are independent of emodin's effect on nuclear factor kappaB. The effect on the uPA system may be via generation of reactive oxygen species
Ile-Ile
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an Ile-Ile or Ile-Val dipeptide can induce limited enzyme activity in the single-chain zymogen form of uPA or its K158A variant, which cannot be activated proteolytically
Ile-Val
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an Ile-Ile or Ile-Val dipeptide can induce limited enzyme activity in the single-chain zymogen form of uPA or its K158A variant, which cannot be activated proteolytically
integrin alpha v beta3
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binds specifically to the enzyme and is required for plasminogen activation, overview
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interleukin beta
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significantly induces uPA expression and activity via protein kinase Calpha-dependent JNK1/2 and NIK cascades. Induction is inhibited by pretreatment with the inhibitors of JNK1/2, SP600125, of protein kinase C, Ro31-8220 and Go6976, or of nuclear factor kappaB, helenalin, and by transfection with dominant negative mutants of protein kinase C alpha, NIK, and IKKbeta, and siRNAs of JNK1/2 and p65
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phorbol 12-myristate 13-acetate
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stimulation of dental pulp cells by tumor necrosis factor-alpha results in increased uPA activity. Tumor necrosis factor-alpha-induced PA release is enhanced in the presence of phorbol 12-myristate 13-acetate
SB 203580
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pretreatment of Hep-G2 cells with SB 203580 increases hepatocyte growth factor-mediated uPA secretion by 50-60%
tumor necrosis factor-alpha
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stimulation of dental pulp cells results in increased uPA activity. Tumor necrosis factor-alpha-induced PA release is enhanced in the presence of phorbol 12-myristate 13-acetate
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additional information
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pro-urokinase upregulates the expression of urokinase-type plasminogen activator in pulmonary arterial endothelial cells, but not the expression level of the uPA receptor
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additional information
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binding of uPA to uPA receptor increases the catalytic efficiency by enhancing its activation by plasmin or other enzymes. uPAR promotes the invasive migration of hair follicles synergizing in manner dependent and independent of uPA during human prenatal morphogenesis
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additional information
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cytokeratin 8 ectoplasmic domain binding by a specific monoclonal antibody inhibits activation of plasminogen, the synthetic dodecapeptide corresponding to the epitope sequence, VKIALEVEIATY, binds uPA. The antibody increases adhesion of breast tumor cells to fibronectin
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additional information
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the enzyme is initially synthesized as single-chain proenzyme with an activity that is many orders of magnitude lower than those of the mature enzyme. Proteolytic cleavage of an exposed loop liberates a new amino terminus that inserts into a hydrophobic pocket and forms a stabilizing salt bridge with a ubiquitously conserved aspartate residue, resulting in a conformational change organizing the mature oxyanion hole
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additional information
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u-PAR in binding to u-PA initiates plasminogen activation. A cleavage-resistant u-PAR, cr-u-PAR, exhibits accelerated internalization and resurfacing due to direct association with the endocytic receptor alpha2-macroglobulin receptor/low density lipoprotein receptor-related protein in the absence of the enzyme inhibitor complex of active u-PA and plasminogen activator inhibitor-1
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additional information
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uPA needs to be activated proteolytically. Sphingosine 1-phosphate receptor S1P1 overexpression in U-118 MG cells results in potent stimulation of uPA activity regardless of S1P treatment, expression of receptors S1P2 and S1P3 does not affect uPA activity
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additional information
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plasmin and urokinase-type plasminogen activator can activate each other through proteolytic cleavage
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additional information
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increased plasminogen activator activity in the lung by administering exogenous uPA or by using mice genetically deficient in the uPA inhibitor plasminogen activator inhibitor-1, PAI-1
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additional information
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uPA transcription and activity is only markedly increased during chronic neurodegeneration, not during acute intracerebral lipopolysaccharide-induced or acute kainate-induced neurodegeneration. Increase in total plasminogen activation with progression of prion disease is apparent in both soluble and membrane fractions
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additional information
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increase of uPA activity and expression by freezing/thawing process in porcine uterus endometrial epithelium cells
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