Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.73 extracted from

  • Obermajer, N.; Doljak, B.; Kos, J.
    Cytokeratin 8 ectoplasmic domain binds urokinase-type plasminogen activator to breast tumor cells and modulates their adhesion, growth and invasiveness (2009), Mol. Cancer, 8, 88.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.73

Activating Compound

Activating Compound Comment Organism Structure
additional information cytokeratin 8 ectoplasmic domain binding by a specific monoclonal antibody inhibits activation of plasminogen, the synthetic dodecapeptide corresponding to the epitope sequence, VKIALEVEIATY, binds uPA. The antibody increases adhesion of breast tumor cells to fibronectin Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information cytokeratin 8 ectoplasmic domain colocalizes with uPA and actin, and binds plasminogen in MCF-10A neoT cells, overview Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Homo sapiens activation plasmin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
MCF-10A neoT cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O activation Homo sapiens plasmin + ?
-
 ?

Synonyms

Synonyms Comment Organism
uPA
-
 Homo sapiens
Urokinase-type plasminogen activator
-
 Homo sapiens