Reference on EC 3.4.21.73 - u-Plasminogen activator
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Loskutoff, D.J.; Schleef, R.R.
Plasminogen activators and their inhibitors
Methods Enzymol.
163
293-302
1988
Homo sapiens
Saksela, O.; Rifkin, D.B.
Cell-associated plasminogen activation: regulation and physiological functions
Annu. Rev. Cell Biol.
4
93-126
1988
Homo sapiens, Rattus norvegicus
Saksela, O.
Plasminogen activation and regulation of pericellular proteolysis
Biochim. Biophys. Acta
823
35-65
1985
Homo sapiens, Mus musculus
Lijnen, H.R.; van Hoef, B.; Nelles, L.; Collen, D.
Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740----Ala) and plasmin-resistant scu-PA (Lys158----Glu)
J. Biol. Chem.
265
5232-5236
1990
Homo sapiens
Takahashi, K.; Kwaan, H.C.; Koh, E.; Tanabe, M.
Enzymatic properties of the phosphorylated urokinase-type plasminogen activator isolated from a human carcinomatous cell line
Biochem. Biophys. Res. Commun.
182
1473-1481
1992
Homo sapiens
Yoshimoto, M.; Ushiyama, Y.; Sakai, M.; Tamaki, S.; Hara, H.; Takahashi, K.; Sawasaki, Y.; Hanada, K.
Characterization of single chain urokinase-type plasminogen activator with a novel amino-acid substitution in the kringle structure
Biochim. Biophys. Acta
1293
83-89
1996
Homo sapiens
Magdolen, V.; Rettenberger, P.; Koppitz, M.; Goretzki, L.; Kessler, H.; Weidle, U.H.; Knig, B.; Graeff, H.; Schmitt, M.; Wilhelm, O.
Systematic mutational analysis of the receptor-binding region of the human urokinase-type plasminogen activator
Eur. J. Biochem.
237
743-751
1996
Homo sapiens
Schmitt, M.; Jnicke, F.; Moniwa, N.; Chucholowski, N.; Pache, L.; Graeff, H.
Tumor-associated urokinase-type plasminogen activator: biological and clinical significance
Biol. Chem. Hoppe-Seyler
373
611-622
1992
Homo sapiens
Wang, C.I.; Yang, Q.; Craik, C.S.
Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin
J. Biol. Chem.
270
12250-12256
1995
Homo sapiens, Mammalia
Lijnen, H.R.; De Cock, F.; Collen, D.
Characterization of the binding of urokinase-type plasminogen activator (u-PA) to plasminogen, to plasminogen-activator inhibitor-1 and to the u-PA receptor
Eur. J. Biochem.
224
567-574
1994
Homo sapiens, Mammalia
Li, Y.; Bokman, A.M.; Llinas, M.; Smith, R.A.G.; Dobson, C.M.
Solution structure of the kringle domain from urokinase-type plasminogen activator
J. Mol. Biol.
235
1548-1559
1994
Homo sapiens
Keski-Oja, J.; Lohi, J.; Tuuttila, A.; Tryggvason, K.; Vartio, T.
Proteolytic processing of the 72,000-Da type IV collagenase by urokinase plasminogen activator
Exp. Cell Res.
202
471-476
1992
Homo sapiens
Li, X.K.; Lijnen, H.R.; Nelles, L.; Hu, M.H.; Collen, D.
Biochemical properties of recombinant mutants of nonglycosylated single chain urokinase-type plasminogen activator
Biochim. Biophys. Acta
1159
37-43
1992
Homo sapiens, Mammalia
Hoyer-Hansen, G.; Ronne, E.; Solberg, H.; Behrendt, N.; Ploug, M.; Lund, L.R.; Ellis, V.; Dano, K.
Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain
J. Biol. Chem.
267
18224-18229
1992
Homo sapiens, Mammalia
Franco, P.; Mastronicola, M.R.; De Cesare, D.; Nolli, M.L.; Wun, T.C.; Verde, P.; Blasi, F.; Stoppelli, M.P.
Separation and characterization of nonphosphorylated and serine-phosphorylated urokinase. Catalytic properties and sensitivity to plasminogen activator inhibitor type 1
J. Biol. Chem.
267
19369-19372
1992
Homo sapiens
Davidow, L.S.; Dumais, D.R.; Smyth, A.P.; Greer, J.; Moir, D.T.
Mutations affecting the activity of urokinase-type plasminogen activator
Protein Eng.
4
923-928
1991
Saccharomyces cerevisiae
Novokhatny, V.; Medved, L.; Mazar, A.; Marcotte, P.; Henkin, J.; Ingham, K.
Domain structure and interactions of recombinant urokinase-type plasminogen activator
J. Biol. Chem.
267
3878-3885
1992
Homo sapiens, Mammalia
Chao, J.
Purification and characterization of rat urinary esterase A, a plasminogen activator
J. Biol. Chem.
258
4434-4439
1983
Rattus norvegicus
Hamelin, J.; Sarmientos, P.; Orsini, G.; Galibert, F.
Implication of cysteine residues in the activity of single-chain urokinase-plasminogen activator
Biochem. Biophys. Res. Commun.
194
978-985
1993
Homo sapiens
Spraggon, G.; Phillips, C.; Nowak, U.K.; Ponting, C.P.; Saunders, D.; Dobson, C.M.; Stuart, D.I.; Jones, E.Y.
The crystal structure of the catalytic domain of human urokinase-type plasminogen activator
Structure
3
681-691
1995
Homo sapiens
Pawse, A.R.; Tarachand, U.
Characterization of urokinase-type plasminogen activator of rat decidual tissue
Biochem. Mol. Biol. Int.
33
775-784
1994
Rattus norvegicus
Bergstrom, R.C.; Coombs, G.S.; Ye, S.; Madison, E.L.; Goldsmith, E.J.; Corey, D.R.
Binding of nonphysiological protein and peptide substrates to proteases: differences between urokinase-type plasminogen activator and trypsin and contributions to the evolution of regulated proteolysis
Biochemistry
42
5395-5402
2003
Homo sapiens
Katz, B.A.; Mackman, R.; Luong, C.; Radika, K.; Martelli, A.; Sprengeler, P.A.; Wang, J.; Chan, H.; Wong, L.
Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator
Chem. Biol.
7
299-312
2000
Homo sapiens
Sun, Z.; Jiang, Y.; Ma, Z.; Wu, H.; Liu, B.F.; Xue, Y.; Tang, W.; Chen, Y.; Li, C.; Zhu, D.; Gurewich, V.; Liu, J.N.; Zhong, M.; Xu, Y.
Identification of a flexible loop region (297-313) of urokinase-type plasminogen activator, which helps determine its catalytic activity
J. Biol. Chem.
272
23818-23823
1997
Homo sapiens
Verner, E.; Katz, B.A.; Spencer, J.R.; Allen, D.; Hataye, J.; Hruzewicz, W.; Hui, H.C.; Kolesnikov, A.; Li, Y.; Luong, C.; Martelli, A.; Radika, K.; Rai, R.; She, M.; Shrader, W.; Sprengeler, P.A.; Trapp, S.; Wang, J.; Young, W.B.; Mackman, R.L.
Development of serine protease inhibitors displaying a multicentered short 2.3 ANG hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa
J. Med. Chem.
44
2753-2771
2001
Homo sapiens
Yang, S.Q.; Craik, C.S.
Engineering bidentate macromolecular inhibitors for trypsin and urokinase-type plasminogen activator
J. Mol. Biol.
279
1001-1011
1998
Homo sapiens
Zeslawska, E.; Jacob, U.; Schweinitz, A.; Coombs, G.; Bode, W.; Madison, E.
Crystals of urokinase type plasminogen activator complexes reveal the binding mode of peptidomimetic inhibitors
J. Mol. Biol.
328
109-118
2003
Homo sapiens
Law, B.; Hsiao, J.K.; Bugge, T.H.; Weissleder, R.; Tung, C.H.
Optical zymography for specific detection of urokinase plasminogen activator activity in biological samples
Anal. Biochem.
338
151-158
2005
Homo sapiens
Barber, C.G.; Dickinson, R.P.; Fish, P.V.
Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-Isoquinolinylguanidines
Bioorg. Med. Chem. Lett.
14
3227-3230
2004
Homo sapiens
Cui, Z.h.; Yang, T.; Gao, Q.g.; Wang, Y.
Urokinase plasminogen activator (uPA) is a positive regulator of outer root sheath keratinocyte proliferation
Cell Biol. Int.
28
571-575
2004
Mus musculus
Al-Ejeh, F.; Croucher, D.; Ranson, M.
Kinetic analysis of plasminogen activator inhibitor type-2: urokinase complex formation and subsequent internalization by carcinoma cell lines
Exp. Cell Res.
297
259-271
2004
Homo sapiens
Li, H.; Soria, C.; Griscelli, F.; Opolon, P.; Soria, J.; Yeh, P.; Legrand, C.; Vannier, J.P.; Belin, D.; Perricaudet, M.; Lu, H.
Amino-terminal fragment of urokinase inhibits tumor cell invasion in vitro and in vivo: respective contribution of the urokinase plasminogen activator receptor-dependent or -independent pathway
Hum. Gene Ther.
16
1157-1167
2005
Homo sapiens, Mus musculus
Gandhari, M.; Arens, N.; Majety, M.; Dorn-Beineke, A.; Hildenbrand, R.
Urokinase-type plasminogen activator induces proliferation in breast cancer cells
Int. J. Oncol.
28
1463-1470
2006
Homo sapiens
Schweinitz, A.; Steinmetzer, T.; Banke, I.J.; Arlt, M.J.; Sturzebecher, A.; Schuster, O.; Geissler, A.; Giersiefen, H.; Zeslawska, E.; Jacob, U.; Kruger, A.; Sturzebecher, J.
Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents
J. Biol. Chem.
279
33613-33622
2004
Homo sapiens (P00749), Homo sapiens
Madsen, M.A.; Deryugina, E.I.; Niessen, S.; Cravatt, B.F.; Quigley, J.P.
Activity-based protein profiling implicates urokinase activation as a key step in human fibrosarcoma intravasation
J. Biol. Chem.
281
15997-16005
2006
Homo sapiens
Gonzalez-Cuevas, J.; Bueno-Topete, M.; Armendariz-Borunda, J.
Urokinase plasminogen activator stimulates function of active forms of stromelysin and gelatinases (MMP-2 and MMP-9) in cirrhotic tissue
J. Gastroenterol. Hepatol.
21
1544-1554
2006
Homo sapiens
Jin, T.; Bokarewa, M.; Tarkowski, A.
Urokinase-type plasminogen activator, an endogenous antibiotic
J. Infect. Dis.
192
429-437
2005
Mus musculus
Joossens, J.; Van der Veken, P.; Lambeir, A.M.; Augustyns, K.; Haemers, A.
Development of irreversible diphenyl phosphonate inhibitors for urokinase plasminogen activator
J. Med. Chem.
47
2411-2413
2004
Homo sapiens
Zhao, G.; Yuan, C.; Bian, C.; Hou, X.; Shi, X.; Ye, X.; Huang, Z.; Huang, M.
Protein expression and preliminary crystallographic analysis of amino-terminal fragment of urokinase-type plasminogen activator
Protein Expr. Purif.
49
71-77
2006
Homo sapiens
Sun, Z.; Liu, J.N.
Mutagenesis at Pro309 of single-chain urokinase-type plasminogen activator alters its catalytic properties
Proteins
61
870-877
2005
Homo sapiens
Huai, Q.; Mazar, A.P.; Kuo, A.; Parry, G.C.; Shaw, D.E.; Callahan, J.; Li, Y.; Yuan, C.; Bian, C.; Chen, L.; Furie, B.; Furie, B.C.; Cines, D.B.; Huang, M.
Structure of human urokinase plasminogen activator in complex with its receptor
Science
311
656-659
2006
Homo sapiens
Van Leer, C.; Stutz, M.; Haeberli, A.; Geiser, T.
Urokinase plasminogen activator released by alveolar epithelial cells modulates alveolar epithelial repair in vitro
Thromb. Haemost.
94
1257-1264
2005
Homo sapiens
DiPasquale, D.M.; Cheng, M.; Billich, W.; Huang, S.A.; van Rooijen, N.; Hornberger, T.A.; Koh, T.J.
Urokinase-type plasminogen activator and macrophages are required for skeletal muscle hypertrophy in mice
Am. J. Physiol. Cell Physiol.
293
C1278-C1285
2007
Mus musculus, Mus musculus C57BL/6
Andersen, L.M.; Wind, T.; Hansen, H.D.; Andreasen, P.A.
A cyclic peptidylic inhibitor of murine urokinase-type plasminogen activator: changing species specificity by substitution of a single residue
Biochem. J.
15
447-457
2008
Homo sapiens, Mus musculus
Sasajima, M.; Moriwaki, S.; Hotta, M.; Kitahara, T.; Takema, Y.
trans-3,4-Dimethyl-3-hydroxyflavanone, a hair growth enhancing active component, decreases active transforming growth factor beta2 (TGF-beta2) through control of urokinase-type plasminogen activator (uPA) on the surface of keratinocytes
Biol. Pharm. Bull.
31
449-453
2008
Homo sapiens
Kim, T.D.; Song, K.S.; Li, G.; Choi, H.; Park, H.D.; Lim, K.; Hwang, B.D.; Yoon, W.H.
Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer
BMC Cancer
6
211
2006
Homo sapiens
Heynekamp, J.J.; Hunsaker, L.A.; Vander Jagt, T.A.; Deck, L.M.; Vander Jagt, D.L.
Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator
BMC Chem. Biol.
6
1
2006
Homo sapiens
Shanmukhappa, K.; Sabla, G.E.; Degen, J.L.; Bezerra, J.A.
Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor
BMC Gastroenterol.
6
40
2006
Mus musculus
Kim, C.K.; Hong, S.H.; Joe, Y.A.; Shim, B.S.; Lee, S.K.; Hong, Y.K.
The recombinant kringle domain of urokinase plasminogen activator inhibits in vivo malignant glioma growth
Cancer Sci.
98
253-258
2007
Homo sapiens
Chu, S.C.; Yang, S.F.; Lue, K.H.; Hsieh, Y.S.; Li, T.J.; Lu, K.H.
Naproxen, meloxicam and methylprednisolone inhibit urokinase plasminogen activator and inhibitor and gelatinases expression during the early stage of osteoarthritis
Clin. Chim. Acta
387
90-96
2008
Homo sapiens
Skeldal, S.; Larsen, J.V.; Pedersen, K.E.; Petersen, H.H.; Egelund, R.; Christensen, A.; Jensen, J.K.; Gliemann, J.; Andreasen, P.A.
Binding areas of urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex for endocytosis receptors of the low-density lipoprotein receptor family, determined by site-directed mutagenesis
FEBS J.
273
5143-5159
2006
Homo sapiens
Crippa, M.P.
Urokinase-type plasminogen activator
Int. J. Biochem. Cell Biol.
39
690-694
2007
Homo sapiens
Stempien-Otero, A.; Plawman, A.; Meznarich, J.; Dyamenahalli, T.; Otsuka, G.; Dichek, D.A.
Mechanisms of cardiac fibrosis induced by urokinase plasminogen activator
J. Biol. Chem.
281
15345-15351
2006
Homo sapiens, Mus musculus
Al-Ayyoubi, M.; Schwartz, B.S.; Gettins, P.G.
Maspin binds to urokinase-type and tissue-type plasminogen activator through exosite-exosite interactions
J. Biol. Chem.
282
19502-19509
2007
Homo sapiens
Bryer, S.C.; Fantuzzi, G.; Van Rooijen, N.; Koh, T.J.
Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regeneration
J. Immunol.
180
1179-1188
2008
Mus musculus, Mus musculus C57BL/6
Joossens, J.; Van der Veken, P.; Surpateanu, G.; Lambeir, A.M.; El-Sayed, I.; Ali, O.M.; Augustyns, K.; Haemers, A.
Diphenyl phosphonate inhibitors for the urokinase-type plasminogen activator: optimization of the P4 position
J. Med. Chem.
49
5785-5793
2006
Mus musculus
Barinka, C.; Parry, G.; Callahan, J.; Shaw, D.E.; Kuo, A.; Bdeir, K.; Cines, D.B.; Mazar, A.; Lubkowski, J.
Structural basis of interaction between urokinase-type plasminogen activator and its receptor
J. Mol. Biol.
363
482-495
2006
Homo sapiens
Tarui, T.; Akakura, N.; Majumdar, M.; Andronicos, N.; Takagi, J.; Mazar, A.P.; Bdeir, K.; Kuo, A.; Yarovoi, S.V.; Cines, D.B.; Takada, Y.
Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation
Thromb. Haemost.
95
524-534
2006
Mus musculus
Liu, Y.; Wang, C.; Yang, Y.; Hou, X.; Wang, J.
Pro-urokinase up-regulates the expression of urokinase-type plasminogen activator (u-PA) in human pulmonary arterial endothelial cells
Thromb. Res.
121
485-491
2008
Homo sapiens
Goscinski, M.A.; Suo, Z.H.; Nesland, J.M.; Chen, W.T.; Zakrzewska, M.; Wang, J.; Zhang, S.; Florenes, V.A.; Giercksky, K.E.
Seprase, dipeptidyl peptidase IV and urokinase-type plasminogen activator expression in dysplasia and invasive squamous cell carcinoma of the esophagus. A study of 229 cases from Anyang Tumor Hospital, Henan Province, China
Oncology
75
49-59
2008
Homo sapiens
Kenny, S.; Duval, C.; Sammut, S.J.; Steele, I.; Pritchard, D.M.; Atherton, J.C.; Argent, R.H.; Dimaline, R.; Dockray, G.J.; Varro, A.
Increased expression of the urokinase plasminogen activator system by Helicobacter pylori in gastric epithelial cells
Am. J. Physiol. Gastrointest. Liver Physiol.
295
G431-G441
2008
Homo sapiens
Bhandary, Y.P.; Velusamy, T.; Shetty, P.; Shetty, R.S.; Idell, S.; Cines, D.B.; Jain, D.; Bdeir, K.; Abraham, E.; Tsuruta, Y.; Shetty, S.
Post-transcriptional regulation of urokinase-type plasminogen activator receptor expression in lipopolysaccharide-induced acute lung injury
Am. J. Respir. Crit. Care Med.
179
288-298
2009
Mus musculus
Fuhrman, B.; Khateeb, J.; Shiner, M.; Nitzan, O.; Karry, R.; Volkova, N.; Aviram, M.
Urokinase plasminogen activator upregulates paraoxonase 2 expression in macrophages via an NADPH oxidase-dependent mechanism
Arterioscler. Thromb. Vasc. Biol.
28
1361-1367
2008
Homo sapiens, Mus musculus
Bahi, A.; Kusnecov, A.W.; Dreyer, J.L.
Effects of urokinase-type plasminogen activator in the acquisition, expression and reinstatement of cocaine-induced conditioned-place preference
Behav. Brain Res.
191
17-25
2008
Rattus norvegicus
Van Den Broeck, T.; Stevenaert, F.; Taveirne, S.; Debacker, V.; Vangestel, C.; Vandekerckhove, B.; Taghon, T.; Matthys, P.; Plum, J.; Held, W.; Dewerchin, M.; Yokoyama, W.M.; Leclercq, G.
Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator
Blood
112
5046-5051
2008
Mus musculus
Veljkovic, D.K.; Rivard, G.E.; Diamandis, M.; Blavignac, J.; Cramer-Borde, E.M.; Hayward, C.P.
Increased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation
Blood
113
1535-1542
2009
Homo sapiens
Alfano, M.; Mariani, S.A.; Elia, C.; Pardi, R.; Blasi, F.; Poli, G.
Ligand-engaged urokinase-type plasminogen activator receptor and activation of the CD11b/CD18 integrin inhibit late events of HIV expression in monocytic cells
Blood
113
1699-1709
2009
Homo sapiens
Herszenyi, L.; Farinati, F.; Cardin, R.; Istvan, G.; Molnar, L.D.; Hritz, I.; De Paoli, M.; Plebani, M.; Tulassay, Z.
Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer
BMC Cancer
8
194
2008
Homo sapiens
Miyake, K.; Shimada, M.; Nishioka, M.; Sugimoto, K.; Batmunkh, E.; Uto, Y.; Nagasawa, H.; Hori, H.
Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer
Cancer Chemother. Pharmacol.
64
885-892
2009
Homo sapiens
Brezillon, N.M.; DaSilva, L.; LHote, D.; Bernex, F.; Piquet, J.; Binart, N.; Morosan, S.; Kremsdorf, D.
Rescue of fertility in homozygous mice for the urokinase plasminogen activator transgene by the transplantation of mouse hepatocytes
Cell Transplant.
17
803-812
2008
Homo sapiens
Bin Hafeez, B.; Adhami, V.M.; Asim, M.; Siddiqui, I.A.; Bhat, K.M.; Zhong, W.; Saleem, M.; Din, M.; Setaluri, V.; Mukhtar, H.
Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator
Clin. Cancer Res.
15
452-459
2009
Homo sapiens
Fevang, B.; Eugen-Olsen, J.; Yndestad, A.; Brosstad, F.; Beiske, K.; Aukrust, P.; Froland, S.S.
Enhanced levels of urokinase plasminogen activator and its soluble receptor in common variable immunodeficiency
Clin. Immunol.
131
438-446
2009
Homo sapiens
Jin, T.; Bokarewa, M.; Zhu, Y.; Tarkowski, A.
Staphylokinase reduces plasmin formation by endogenous plasminogen activators
Eur. J. Haematol.
81
8-17
2008
Homo sapiens
Lee, K.H.; Kim, J.R.
Reactive oxygen species regulate the generation of urokinase plasminogen activator in human hepatoma cells via MAPK pathways after treatment with hepatocyte growth factor
Exp. Mol. Med.
41
180-188
2009
Homo sapiens
Kowal, K.; Zukowski, S.; Moniuszko, M.; Bodzenta-?ukaszyk, A.
Plasminogen activator inhibitor-1 (PAI-1) and urokinase plasminogen activator (uPA) in sputum of allergic asthma patients
Folia Histochem. Cytobiol.
46
193-198
2008
Homo sapiens
Biermann, J.C.; Holzscheiter, L.; Kotzsch, M.; Luther, T.; Kiechle-Bahat, M.; Sweep, F.C.; Span, P.N.; Schmitt, M.; Magdolen, V.
Quantitative RT-PCR assays for the determination of urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 mRNA in primary tumor tissue of breast cancer patients: comparison to antigen quantification by ELISA
Int. J. Mol. Med.
21
251-259
2008
Homo sapiens
Lund, I.K.; Joegi, A.; Rono, B.; Rasch, M.G.; Lund, L.R.; Almholt, K.; Gardsvoll, H.; Behrendt, N.; Romer, J.; Hoyer-Hansen, G.
Antibody-mediated targeting of the urokinase-type plasminogen activator proteolytic function neutralizes fibrinolysis in vivo
J. Biol. Chem.
283
32506-32515
2008
Mus musculus
Cheng, C.Y.; Hsieh, H.L.; Sun, C.C.; Lin, C.C.; Luo, S.F.; Yang, C.M.
IL-1 beta induces urokinase-plasminogen activator expression and cell migration through PKC alpha, JNK1/2, and NF-kappaB in A549 cells
J. Cell. Physiol.
219
183-193
2009
Homo sapiens
Bayliss, M.A.; Venn, R.F.; Edgington, A.M.; Webster, R.; Walker, D.K.
Determination of a potent urokinase-type plasminogen activator, UK-356,202, in plasma at pg/mL levels using column-switching HPLC and fluorescence detection
J. Chromatogr. B
877
121-126
2009
Homo sapiens
Karthikeyan, C.; Moorthy, N.S.; Trivedi, P.
QSAR study of substituted 2-pyridinyl guanidines as selective urokinase-type plasminogen activator (uPA) inhibitors
J. Enzyme Inhib. Med. Chem.
24
6-13
2009
Homo sapiens
Gueler, F.; Rong, S.; Mengel, M.; Park, J.K.; Kiyan, J.; Kirsch, T.; Dumler, I.; Haller, H.; Shushakova, N.
Renal urokinase-type plasminogen activator (uPA) receptor but not uPA deficiency strongly attenuates ischemia reperfusion injury and acute kidney allograft rejection
J. Immunol.
181
1179-1189
2008
Mus musculus
Frederickson, M.; Callaghan, O.; Chessari, G.; Congreve, M.; Cowan, S.R.; Matthews, J.E.; McMenamin, R.; Smith, D.M.; Vinkovic, M.; Wallis, N.G.
Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator
J. Med. Chem.
51
183-186
2008
Rattus norvegicus
Armstead, W.M.; Christine, A.J.; Higazi, A.A.; Cines, D.B.
Urokinase plasminogen activator impairs SNP and PGE2 cerebrovasodilation after brain injury through activation of LRP and ERK MAPK
J. Neurotrauma
25
1375-1381
2008
Sus scrofa
Hashizume, H.; Kamio, N.; Nakao, S.; Matsushima, K.; Sugiya, H.
Protein kinase C synergistically stimulates tumor necrosis factor-alpha-induced secretion of urokinase-type plasminogen activator in human dental pulp cells
J. Physiol. Sci.
58
83-86
2008
Homo sapiens
Plekhanova, O.; Berk, B.C.; Bashtrykov, P.; Brooks, A.I.; Tkachuk, V.; Parfyonova, Y.
Oligonucleotide microarrays reveal regulated genes related to inward arterial remodeling induced by urokinase plasminogen activator
J. Vasc. Res.
46
177-187
2008
Rattus norvegicus
Dong, Z.; Saliganan, A.D.; Meng, H.; Nabha, S.M.; Sabbota, A.L.; Sheng, S.; Bonfil, R.D.; Cher, M.L.
Prostate cancer cell-derived urokinase-type plasminogen activator contributes to intraosseous tumor growth and bone turnover
Neoplasia
10
439-449
2008
Homo sapiens
Patel, T.H.; Sprague, S.; Lai, Q.; Jimenez, D.F.; Barone, C.M.; Ding, Y.
Blood brain barrier (BBB) dysfunction associated with increased expression of tissue and urokinase plasminogen activators following peripheral thermal injury
Neurosci. Lett.
444
222-226
2008
Rattus norvegicus
Naruse, K.; Lash, G.E.; Bulmer, J.N.; Innes, B.A.; Otun, H.A.; Searle, R.F.; Robson, S.C.
The urokinase plasminogen activator (uPA) system in uterine natural killer cells in the placental bed during early pregnancy
Placenta
30
398-404
2009
Homo sapiens
Papanikolaou, T.; Amiridis, G.S.; Dimitriadis, I.; Vainas, E.; Rekkas, C.A.
Effect of plasmin, plasminogen activators and a plasmin inhibitor on bovine in vitro embryo production
Reprod. Fertil. Dev.
20
320-327
2008
Bos taurus
Gutova, M.; Najbauer, J.; Frank, R.T.; Kendall, S.E.; Gevorgyan, A.; Metz, M.Z.; Guevorkian, M.; Edmiston, M.; Zhao, D.; Glackin, C.A.; Kim, S.U.; Aboody, K.S.
Urokinase plasminogen activator and urokinase plasminogen activator receptor mediate human stem cell tropism to malignant solid tumors
Stem Cells
26
1406-1413
2008
Homo sapiens
Zhou, H.; Wu, X.; Lu, X.; Chen, G.; Ye, X.; Huang, J.
Evaluation of plasma urokinase-type plasminogen activator and urokinase-type plasminogen-activator receptor in patients with acute and chronic hepatitis B
Thromb. Res.
123
537-542
2009
Homo sapiens
Lee, K.H.; Choi, E.Y.; Hyun, M.S.; Eun, J.R.; Jang, B.I.; Kim, T.N.; Lee, H.J.; Lee, D.S.; Yun, S.S.; Kim, H.J.; Kim, J.H.; Kim, J.R.
Cellular mechanisms of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MAPK signaling in hepatocellular carcinoma
Tumori
94
523-530
2008
Homo sapiens
Radha, K.S.; Madhyastha, H.K.; Nakajima, Y.; Omura, S.; Maruyama, M.
Emodin upregulates urokinase plasminogen activator, plasminogen activator inhibitor-1 and promotes wound healing in human fibroblasts
Vascul. Pharmacol.
48
184-190
2008
Homo sapiens
van Zoelen, M.A.; Florquin, S.; de Beer, R.; Pater, J.M.; Verstege, M.I.; Meijers, J.C.; van der Poll, T.
Urokinase plasminogen activator receptor-deficient mice demonstrate reduced hyperoxia-induced lung injury
Am. J. Pathol.
174
2182-2189
2009
Mus musculus, Mus musculus C57BL/6
Kiessling, J.W.; Cines, D.B.; Higazi, A.A.; Armstead, W.M.
Inhibition of integrin alphavbeta3 prevents urokinase plasminogen activator-mediated impairment of cerebrovasodilation after cerebral hypoxia/ischemia
Am. J. Physiol. Heart Circ. Physiol.
296
H862-H867
2009
Sus scrofa
Kuramoto, E.; Nishiuma, T.; Kobayashi, K.; Yamamoto, M.; Kono, Y.; Funada, Y.; Kotani, Y.; Sisson, T.; Simon, R.; Nishimura, Y.
Inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model
Am. J. Physiol. Lung Cell Mol. Physiol.
296
L337-L346
2009
Mus musculus, Mus musculus C57/BL6J
Uchiba, M.; Imamura, T.; Hata, H.; Tatetsu, H.; Yonemura, Y.; Ueda, M.; Wada, Y.; Mitsuya, H.; Ando, Y.
Excessive fibrinolysis in AL-amyloidosis is induced by urokinae-type plasminogen activator from bone marrow plasma cells
Amyloid
16
89-93
2009
Homo sapiens
Gao, Q.; Fu, G.; Huang, G.; Lian, X.; Yu, J.; Yang, T.
Relationship between urokinase plasminogen activator receptor (uPAR) and the invasion of human prenatal hair follicle
Arch. Dermatol. Res.
302
409-418
2009
Homo sapiens
Yang, H.; Choi, H.J.; Park, S.H.; Kim, J.S.; Moon, Y.
Macrophage inhibitory cytokine-1 (MIC-1) and subsequent urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 colon cancer cells
Biochem. Pharmacol.
78
1205-1213
2009
Homo sapiens
Boetkjaer, K.A.; Byszuk, A.A.; Andersen, L.M.; Christensen, A.; Andreasen, P.A.; Blouse, G.E.
Nonproteolytic induction of catalytic activity into the single-chain form of urokinase-type plasminogen activator by dipeptides
Biochemistry
48
9606-9617
2009
Homo sapiens
West, C.W.; Adler, M.; Arnaiz, D.; Chen, D.; Chu, K.; Gualtieri, G.; Ho, E.; Huwe, C.; Light, D.; Phillips, G.; Pulk, R.; Sukovich, D.; Whitlow, M.; Yuan, S.; Bryant, J.
Identification of orally bioavailable, non-amidine inhibitors of urokinase plasminogen activator (uPA)
Bioorg. Med. Chem. Lett.
19
5712-5715
2009
Homo sapiens
Zhu, Y.; Cheng, Z.; Dai, H.; Hu, L.
The relationship between urokinase plasminogen activator/plasminogen activator inhibitor type-1 expression in myoma/myometrium and mechanism of uterine artery occlusion by laparoscopy for uterine myoma treatment
Blood Coagul. Fibrinolysis
20
565-570
2009
Homo sapiens
Sisson, T.H.; Nguyen, M.H.; Yu, B.; Novak, M.L.; Simon, R.H.; Koh, T.J.
Urokinase-type plasminogen activator increases hepatocyte growth factor activity required for skeletal muscle regeneration
Blood
114
5052-5061
2009
Mus musculus, Mus musculus C57BL/6
Ulisse, S.; Baldini, E.; Mottolese, M.; Sentinelli, S.; Gargiulo, P.; Brancato, V.; Sorrenti, S.; Di Benedetto, A.; De Antoni, E.; DArmiento, M.
Increased expression of urokinase plasminogen activator and its cognate receptor in human seminomas
BMC Cancer
10
151
2010
Homo sapiens
Stewart, C.E.; Sayers, I.
Characterisation of urokinase plasminogen activator receptor variants in human airway and peripheral cells
BMC Mol. Biol.
10
75
2009
Homo sapiens
Killeen, S.D.; Wang, J.H.; Andrews, E.J.; Redmond, H.P.
Bacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-kappaB-dependent activation of the urokinase plasminogen activator system
Br. J. Cancer
100
1589-1602
2009
Homo sapiens
Tkachuk, V.A.; Plekhanova, O.S.; Parfyonova, Y.V.
Regulation of arterial remodeling and angiogenesis by urokinase-type plasminogen activator
Can. J. Physiol. Pharmacol.
87
231-251
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Ports, M.O.; Nagle, R.B.; Pond, G.D.; Cress, A.E.
Extracellular engagement of alpha6 integrin inhibited urokinase-type plasminogen activator-mediated cleavage and delayed human prostate bone metastasis
Cancer Res.
69
5007-5014
2009
Homo sapiens
Kim, T.S.; Kwon, E.H.; Kim, S.U.; Choi, H.S.; Lim, H.J.; Park, S.B.; Park, S.J.; Koo, D.B.; Park, C.K.; Lee, D.S.
Activation and expression of urokinase-type plasminogen activator are modulated by freezing/thawing process through activation of redox signal pathway in primary porcine endometrial cells
Cryobiology
60
211-216
2010
Sus scrofa
Cunningham, O.; Campion, S.; Perry, V.H.; Murray, C.; Sidenius, N.; Docagne, F.; Cunningham, C.
Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation
Glia
57
1802-1814
2009
Mus musculus, Mus musculus C57BL/6
Shih, Y.W.; Lee, Y.C.; Wu, P.F.; Lee, Y.B.; Chiang, T.A.
Plumbagin inhibits invasion and migration of liver cancer HepG2 cells by decreasing productions of matrix metalloproteinase-2 and urokinase-plasminogen activator
Hepatol. Res.
39
998-1009
2009
Homo sapiens
Minoo, P.; Baker, K.; Baumhoer, D.; Terracciano, L.; Lugli, A.; Zlobec, I.
Urokinase-type plasminogen activator is a marker of aggressive phenotype and an independent prognostic factor in mismatch repair-proficient colorectal cancer
Hum. Pathol.
41
70-78
2010
Homo sapiens
Bae, K.B.; Jeong, Y.J.; Won, H.J.; Hong, K.H.; Choi, I.W.; Seo, S.K.; Park, S.G.
A human monoclonal antibody scFv to urokinase plasminogen activator
Hybridoma
29
147-152
2010
Homo sapiens
Xue, A.; Xue, M.; Jackson, C.; Smith, R.C.
Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling
Int. J. Biochem. Cell Biol.
41
1731-1738
2009
Homo sapiens
Zhou, H.; Tang, Y.; Liang, X.; Yang, X.; Yang, J.; Zhu, G.; Zheng, M.; Zhang, C.
RNAi targeting urokinase-type plasminogen activator receptor inhibits metastasis and progression of oral squamous cell carcinoma in vivo
Int. J. Cancer
125
453-462
2009
Homo sapiens
Villar, V.; Koci?, J.; Santibanez, J.F.
Spred2 inhibits TGF-beta1-induced urokinase type plasminogen activator expression, cell motility and epithelial mesenchymal transition
Int. J. Cancer
127
77-85
2010
Homo sapiens
Dmello, V.; Singh, S.; Wu, Y.; Birge, R.B.
The urokinase plasminogen activator receptor promotes efferocytosis of apoptotic cells
J. Biol. Chem.
284
17030-17038
2009
Homo sapiens
Cheng, X.; Shen, Z.; Yin, L.; Lu, S.H.; Cui, Y.
ECRG2 regulates cell migration/invasion through urokinase-type plasmin activator receptor (uPAR)/beta1 integrin pathway
J. Biol. Chem.
284
30897-30906
2009
Homo sapiens
Nieves, E.C.; Manchanda, N.
A cleavage-resistant urokinase plasminogen activator receptor exhibits dysregulated cell-surface clearance
J. Biol. Chem.
285
12595-12603
2010
Homo sapiens
Nagase, K.; Kobayashi, H.; Yoshikawa, E.; Kurita, N.
Ab initio molecular orbital calculations on specific interactions between urokinase-type plasminogen activator and its receptor
J. Mol. Graph. Model.
28
46-53
2009
Homo sapiens
Humphries, J.; Gossage, J.A.; Modarai, B.; Burnand, K.G.; Sisson, T.H.; Murdoch, C.; Smith, A.
Monocyte urokinase-type plasminogen activator up-regulation reduces thrombus size in a model of venous thrombosis
J. Vasc. Surg.
50
1127-1134
2009
Homo sapiens
Young, N.; Pearl, D.K.; Van Brocklyn, J.R.
Sphingosine-1-phosphate regulates glioblastoma cell invasiveness through the urokinase plasminogen activator system and CCN1/Cyr61
Mol. Cancer Res.
7
23-32
2009
Homo sapiens
Obermajer, N.; Doljak, B.; Kos, J.
Cytokeratin 8 ectoplasmic domain binds urokinase-type plasminogen activator to breast tumor cells and modulates their adhesion, growth and invasiveness
Mol. Cancer
8
88
2009
Homo sapiens
Shin, S.M.; Cho, K.S.; Choi, M.S.; Lee, S.H.; Han, S.H.; Kang, Y.S.; Kim, H.J.; Cheong, J.H.; Shin, C.Y.; Ko, K.H.
Urokinase-type plasminogen activator induces BV-2 microglial cell migration through activation of matrix metalloproteinase-9
Neurochem. Res.
35
976-985
2010
Mus musculus
Iyer, A.M.; Zurolo, E.; Boer, K.; Baayen, J.C.; Giangaspero, F.; Arcella, A.; Di Gennaro, G.C.; Esposito, V.; Spliet, W.G.; van Rijen, P.C.; Troost, D.; Gorter, J.A.; Aronica, E.
Tissue plasminogen activator and urokinase plasminogen activator in human epileptogenic pathologies
Neuroscience
167
929-945
2010
Homo sapiens
Armstrong, A.F.; Lemon, J.A.; Czorny, S.K.; Singh, G.; Valliant, J.F.
Evaluation of single amino acid chelate derivatives and regioselective radiolabelling of a cyclic peptide for the urokinase plasminogen activator receptor
Nucl. Med. Biol.
36
907-917
2009
Homo sapiens
Li, X.F.; Yan, P.J.; Shao, Z.M.
Downregulation of miR-193b contributes to enhance urokinase-type plasminogen activator (uPA) expression and tumor progression and invasion in human breast cancer
Oncogene
28
3937-3948
2009
Homo sapiens
Sandra, D.; Radha, M.; Harishkumar, M.; Yuichi, N.; Sayuri, O.; Masugi, M.
Downregulation of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 by grape seed proanthocyanidin extract
Phytomedicine
17
42-46
2010
Homo sapiens
Sgier, D.; Zuberbuehler, K.; Pfaffen, S.; Neri, D.
Isolation and characterization of an inhibitory human monoclonal antibody specific to the urokinase-type plasminogen activator, uPA
Protein Eng. Des. Sel.
23
261-269
2010
Homo sapiens
Odaka, T.; Kobayashi, K.; Takahashi, K.; Nakamura, H.; Matsuoka, T.
Effect of prostaglandin E2 on urokinase-type plasminogen activator production by human lung fibroblasts
Scand. J. Clin. Lab. Invest.
69
225-233
2009
Homo sapiens
Kumano, M.; Miyake, H.; Muramaki, M.; Furukawa, J.; Takenaka, A.; Fujisawa, M.
Expression of urokinase-type plasminogen activator system in prostate cancer: correlation with clinicopathological outcomes in patients undergoing radical prostatectomy
Urol. Oncol.
27
180-186
2009
Homo sapiens
Nassar, T.; Yarovoi, S.; Fanne, R.; Waked, O.; Allen, T.; Idell, S.; Cines, D.; Higazi, A.
Urokinase plasminogen activator regulates pulmonary arterial contractility and vascular permeability in mice
Am. J. Respir. Cell Mol. Biol.
45
1015-1021
2011
Homo sapiens
Yang, Y.; Friggeri, A.; Banerjee, S.; Bdeir, K.; Cines, D.B.; Liu, G.; Abraham, E.
Urokinase-type plasminogen activator inhibits efferocytosis of neutrophils
Am. J. Respir. Crit. Care Med.
182
1516-1523
2010
Mus musculus, Mus musculus C57BL/6
Beaufort, N.; Seweryn, P.; de Bentzmann, S.; Tang, A.; Kellermann, J.; Grebenchtchikov, N.; Schmitt, M.; Sommerhoff, C.P.; Pidard, D.; Magdolen, V.
Activation of human pro-urokinase by unrelated proteases secreted by Pseudomonas aeruginosa
Biochem. J.
428
473-482
2010
Homo sapiens
Botkjaer, K.A.; Fogh, S.; Bekes, E.C.; Chen, Z.; Blouse, G.E.; Jensen, J.M.; Mortensen, K.K.; Huang, M.; Deryugina, E.; Quigley, J.P.; Declerck, P.J.; Andreasen, P.A.
Targeting the autolysis loop of urokinase-type plasminogen activator with conformation-specific monoclonal antibodies
Biochem. J.
438
39-51
2011
Homo sapiens
Venkatraman, L.; Li, H.; Dewey Jr., C.; White, J.; Bhowmick, S.; Yu, H.; Tucker-Kellogg, L.
Steady states and dynamics of urokinase-mediated plasmin activation in silico and in vitro
Biophys. J.
101
1825-1834
2011
Homo sapiens
Uchino, R.; Madhyastha, R.; Madhyastha, H.; Dhungana, S.; Nakajima, Y.; Omura, S.; Maruyama, M.
NFkappaB-dependent regulation of urokinase plasminogen activator by proanthocyanidin-rich grape seed extract: effect on invasion by prostate cancer cells
Blood Coagul. Fibrinolysis
21
528-533
2010
Homo sapiens
Farris, S.D.; Hu, J.H.; Krishnan, R.; Emery, I.; Chu, T.; Du, L.; Kremen, M.; Dichek, H.L.; Gold, E.; Ramsey, S.A.; Dichek, D.A.
Mechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis: role of the uPA receptor and S100A8/A9 proteins
J. Biol. Chem.
286
22665-22677
2011
Mus musculus, Mus musculus C57BL/6
Makarova, A.M.; Lebedeva, T.V.; Nassar, T.; Higazi, A.A.; Xue, J.; Carinato, M.E.; Bdeir, K.; Cines, D.B.; Stepanova, V.
Urokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase
J. Biol. Chem.
286
23044-23053
2011
Homo sapiens
Lin, Z.; Jiang, L.; Yuan, C.; Jensen, J.K.; Zhang, X.; Luo, Z.; Furie, B.C.; Furie, B.; Andreasen, P.A.; Huang, M.
Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1
J. Biol. Chem.
286
7027-7032
2011
Homo sapiens (P00749)
Schroetzlmair, F.; Kopitz, C.; Halbgewachs, B.; Lu, F.; Alguel, H.; Bruenner, N.; Gaensbacher, B.; Krueger, A.
Tissue inhibitor of metalloproteinases-1-induced scattered liver metastasis is mediated by host-derived urokinase-type plasminogen activator
J. Cell. Mol. Med.
14
2760-2770
2010
Homo sapiens, Mus musculus
Markowska, A.; Bruzgo, I.; Midura-Nowaczek, K.
Synthesis and activity of amides of tripeptides as potential urokinase inhibitors
J. Enzyme Inhib. Med. Chem.
25
139-142
2010
Homo sapiens
Chao, S.C.; Hu, D.N.; Yang, P.Y.; Lin, C.Y.; Yang, S.F.
Overexpression of urokinase-type plasminogen activator in pterygia and pterygium fibroblasts
Mol. Vis.
17
23-31
2011
Homo sapiens
Matsunoshita, Y.; Ijiri, K.; Ishidou, Y.; Nagano, S.; Yamamoto, T.; Nagao, H.; Komiya, S.; Setoguchi, T.
Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1
PLoS ONE
6
e16234
2011
Homo sapiens
Graziano, F.; Elia, C.; Laudanna, C.; Poli, G.; Alfano, M.
Urokinase plasminogen activator inhibits HIV virion release from macrophage-differentiated chronically infected cells via activation of RhoA and PKCepsilon
PLoS ONE
6
e23674
2011
Homo sapiens
Paland, N.; Aharoni, S.; Fuhrman, B.
Urokinase-type plasminogen activator (uPA) modulates monocyte-to-macrophage differentiation and prevents Ox-LDL-induced macrophage apoptosis
Atherosclerosis
231
29-38
2013
Mus musculus, Homo sapiens (P00749), Mus musculus C57BL/6
Chulsky, S.; Paland, N.; Lazarovich, A.; Fuhrman, B.
Urokinase-type plasminogen activator (uPA) decreases hepatic SR-BI expression and impairs HDL-mediated reverse cholesterol transport
Atherosclerosis
233
11-18
2014
Homo sapiens
Paland, N.; Gamliel-Lazarovich, A.; Coleman, R.; Fuhrman, B.
Urokinase-type plasminogen activator (uPA) stimulates triglyceride synthesis in Huh7 hepatoma cells via p38-dependent upregulation of DGAT2
Atherosclerosis
237
200-207
2014
Mus musculus, Homo sapiens (P00749), Mus musculus C57BL/6
Liu, Z.; Kromann-Hansen, T.; Lund, I.K.; Hosseini, M.; Jensen, K.J.; Hoeyer-Hansen, G.; Andreasen, P.A.; Soerensen, H.P.
Interconversion of active and inactive conformations of urokinase-type plasminogen activator
Biochemistry
51
7804-7811
2012
Mus musculus
Krstic, J.; Obradovic, H.; Jaukovic, A.; Okic-Dordevic, I.; Trivanovic, D.; Kukolj, T.; Mojsilovic, S.; Ilic, V.; Santibanez, J.F.; Bugarski, D.
Urokinase type plasminogen activator mediates interleukin-17-induced peripheral blood mesenchymal stem cell motility and transendothelial migration
Biochim. Biophys. Acta
1853
431-444
2015
Homo sapiens (P00749)
Massey, A.P.; Harley, W.R.; Pasupuleti, N.; Gorin, F.A.; Nantz, M.H.
2-Amidino analogs of glycine-amiloride conjugates: inhibitors of urokinase-type plasminogen activator
Bioorg. Med. Chem. Lett.
22
2635-2639
2012
Homo sapiens (P00749), Homo sapiens
Venkatraj, M.; Messagie, J.; Joossens, J.; Lambeir, A.M.; Haemers, A.; Van der Veken, P.; Augustyns, K.
Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA)
Bioorg. Med. Chem.
20
1557-1568
2012
Homo sapiens (P00749)
Jiang, L.; Zhao, B.; Xu, P.; Soerensen, H.P.; Jensen, J.K.; Christensen, A.; Hosseini, M.; Nielsen, N.C.; Jensen, K.J.; Andreasen, P.A.; Huang, M.
Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues
Int. J. Biochem. Cell Biol.
62
88-92
2015
Homo sapiens, Mus musculus
Ji, H.L.; Zhao, R.; Komissarov, A.A.; Chang, Y.; Liu, Y.; Matthay, M.A.
Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites
J. Biol. Chem.
290
5241-5255
2015
Homo sapiens
Fleetwood, A.J.; Achuthan, A.; Schultz, H.; Nansen, A.; Almholt, K.; Usher, P.; Hamilton, J.A.
Urokinase plasminogen activator is a central regulator of macrophage three-dimensional invasion, matrix degradation, and adhesion
J. Immunol.
192
3540-3547
2014
Mus musculus, Mus musculus C57BL/6
Al-Shaer, M.A.; Khanfar, M.A.; Taha, M.O.
Discovery of novel urokinase plasminogen activator (uPA) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis
J. Mol. Model.
20
2080
2014
Homo sapiens (P00749)
Wu, F.; Catano, M.; Echeverry, R.; Torre, E.; Haile, W.B.; An, J.; Chen, C.; Cheng, L.; Nicholson, A.; Tong, F.C.; Park, J.; Yepes, M.
Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke
J. Neurosci.
34
14219-14232
2014
Mus musculus, Mus musculus E16-E18
Asuthkar, S.; Stepanova, V.; Lebedeva, T.; Holterman, A.L.; Estes, N.; Cines, D.B.; Rao, J.S.; Gondi, C.S.
Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer
Mol. Biol. Cell
24
2620-2632
2013
Homo sapiens (P00749)
Zha, X.; Diaz, R.; Franco, J.J.; Sanchez, V.F.; Fasoli, E.; Barletta, G.; Carvajal, A.; Bansal, V.
Inhibitors of urokinase type plasminogen activator and cytostatic activity from crude plants extracts
Molecules
18
8945-8958
2013
Homo sapiens (P00749), Homo sapiens
Meznarich, J.; Malchodi, L.; Helterline, D.; Ramsey, S.A.; Bertko, K.; Plummer, T.; Plawman, A.; Gold, E.; Stempien-Otero, A.
Urokinase plasminogen activator induces pro-fibrotic/m2 phenotype in murine cardiac macrophages
PLoS ONE
8
e57837
2013
Mus musculus
Sanderson-Smith, M.L.; Zhang, Y.; Ly, D.; Donahue, D.; Hollands, A.; Nizet, V.; Ranson, M.; Ploplis, V.A.; Walker, M.J.; Castellino, F.J.
A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection
PLoS Pathog.
9
e1003469
2013
Homo sapiens (P00749), Homo sapiens
Jendroszek, A.; Madsen, J.; Chana-Munoz, A.; Dupont, D.; Christensen, A.; Panitz, F.; Fuechtbauer, E.; Lovell, S.; Jensen, J.
Biochemical and structural analyses suggest that plasminogen activators coevolved with their cognate protein substrates and inhibitors
J. Biol. Chem.
294
3794-3805
2019
Homo sapiens (P00749), Homo sapiens
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