3.4.21.41: complement subcomponent C1r

This is an abbreviated version!
For detailed information about complement subcomponent C1r, go to the full flat file.

Word Map on EC 3.4.21.41

3.4.21.41

c1s

multimolecular

autoactivation

chordin

masp-1

ccp1

mannan-binding

collagen-like

c1s-c1r-c1r-c1s

angioedema

dorsoventral

mbl-associated

dorsal-ventral

medicine

Reaction

Selective cleavage of Lys(or Arg)-/-Ile bond in complement subcomponent C1s to form C_overbar_1s_ (EC 3.4.21.42) =

Synonyms

activated complement C1r, C1r, C1r protease, C1r serine protease, C1r-LP, C1rbar-esterase, complement C1r subcomponent-like protein, complement C1r, activated, complement protease C1r, complement subcomponent 1r, CUB, multiprotein complex C1, proteases C1r, serine protease C1r, Xld, xolloid

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.41 complement subcomponent C1r

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Results	in table
2	Activating Compound
958	AA Sequence
1	Application
1	CAS Registry Number
15	Cloned(Commentary)
5	Crystallization (Commentary)
9	Disease/ Diagnostics
2	Expression
10	General Information
2	General Stability
30	Inhibitors
2	kcat/KM [mM/s]
7	KM Value [mM]
4	Localization
4	Metals/Ions
9	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
46	Organism
16	PDB ID
4	pH Optimum
2	pI Value
17	Posttranslational Modification
21	Protein Variants
11	Purification (Commentary)
1	Reaction
1	Reaction Type
46	Reference
3	Renatured (Commentary)
30	Source Tissue
1	Storage Stability
45	Substrates and Products (Substrate)
17	Subunits
30	Synonyms
1	Temperature Optimum [°C]
3	Temperature Stability [°C]
5	Turnover Number [1/s]

Purification

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Purification on EC 3.4.21.41 - complement subcomponent C1r

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Homo sapiens

81395, 81403, 717603

commercial preparation

from human plasma

from inclusion bodies, ion exchange chromatography (Q-Sepharose), gel filtration

Homo sapiens

717786

maltose affinity column chromatography

Sebastes schlegelii

A0A2I6BQJ9

753377

nickel-Sepharose affinity column chromatography and Superdex 200 gel filtration

proenzyme C1r

recombinant active catalytic region of C1r from Escherichia coli strain BL21(DE3) by ion exchange chromatography and gel filtration

Homo sapiens

P00736

683889

solubilization of inclusion-bodies

Homo sapiens

717587