3.4.21.41: complement subcomponent C1r

This is an abbreviated version!
For detailed information about complement subcomponent C1r, go to the full flat file.

Reaction

Selective cleavage of Lys(or Arg)-/-Ile bond in complement subcomponent C1s to form C_overbar_1s_ (EC 3.4.21.42) =

Synonyms

activated complement C1r, C1r, C1r protease, C1r serine protease, C1r-LP, C1rbar-esterase, complement C1r subcomponent-like protein, complement C1r, activated, complement protease C1r, complement subcomponent 1r, CUB, multiprotein complex C1, proteases C1r, serine protease C1r, Xld, xolloid

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.41 complement subcomponent C1r

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Results	in table
2	Activating Compound
958	AA Sequence
1	Application
1	CAS Registry Number
15	Cloned(Commentary)
5	Crystallization (Commentary)
9	Disease/ Diagnostics
2	Expression
10	General Information
2	General Stability
30	Inhibitors
2	kcat/KM [mM/s]
7	KM Value [mM]
4	Localization
4	Metals/Ions
9	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
46	Organism
16	PDB ID
4	pH Optimum
2	pI Value
17	Posttranslational Modification
21	Protein Variants
11	Purification (Commentary)
1	Reaction
1	Reaction Type
46	Reference
3	Renatured (Commentary)
30	Source Tissue
1	Storage Stability
45	Substrates and Products (Substrate)
17	Subunits
30	Synonyms
1	Temperature Optimum [°C]
3	Temperature Stability [°C]
5	Turnover Number [1/s]

Turnover Number

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Turnover Number on EC 3.4.21.41 - complement subcomponent C1r

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0021

MASP-3 K448Q zymogen

Homo sapiens

P00736

pH 7.4, 37°C

732102

-

18.3

N-acetyl-Arg methyl ester

Homo sapiens

-

-

81392

12.5

N-Acetyl-Gly-Lys methyl ester

Homo sapiens

-

-

81392

0.0645

zymogen C1s

Homo sapiens

P00736

pH 7.4, 37°C, substrate is a fragment consisting of complement control protein domains, CCP1 and CCP2, plus serine

732102

-

additional information

additional information

Homo sapiens

-

activated C1r and its wild-type CCP1/2-SP and CCP2-SP fragments all cleave acetyl-Gly-Lys-methyl ester with turnover numbers ranging from 8.2 s to 9.2 s

652176

-