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3.4.21.41: complement subcomponent C1r

This is an abbreviated version!
For detailed information about complement subcomponent C1r, go to the full flat file.

Word Map on EC 3.4.21.41

Reaction

Selective cleavage of Lys(or Arg)-/-Ile bond in complement subcomponent C1s to form C_overbar_1s_ (EC 3.4.21.42) =

Synonyms

activated complement C1r, C1r, C1r protease, C1r serine protease, C1r-LP, C1rbar-esterase, complement C1r subcomponent-like protein, complement C1r, activated, complement protease C1r, complement subcomponent 1r, CUB, multiprotein complex C1, proteases C1r, serine protease C1r, Xld, xolloid

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.41 complement subcomponent C1r

Engineering

Engineering on EC 3.4.21.41 - complement subcomponent C1r

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C309W
the mutation is associated with periodontal Ehlers-Danlos syndrome
C338R
the mutation is associated with periodontal Ehlers-Danlos syndrome
C358F
the mutation is associated with periodontal Ehlers-Danlos syndrome
C371W
the mutation is associated with periodontal Ehlers-Danlos syndrome
D290G
the mutation is associated with periodontal Ehlers-Danlos syndrome
G297D
the mutation is associated with periodontal Ehlers-Danlos syndrome
I306-C309del
the deletion mutations are associated with periodontal Ehlers-Danlos syndrome
L300P
the mutation is associated with periodontal Ehlers-Danlos syndrome
R301P
the mutation is associated with periodontal Ehlers-Danlos syndrome
R401-Y405del
the deletion mutations are associated with periodontal Ehlers-Danlos syndrome
R446Q
-
stabilized in the single-chain proenzyme form by mutation at the cleavage site, no esterolytic activity with acetyl-Gly-Lys-methyl ester
R463X
S637A
-
stabilized in the single-chain proenzyme form by mutation at the active site serine residue, no esterolytic activity with acetyl-Gly-Lys-methyl ester
S654A
-
mutant without autoactivation
V50D
the mutation is associated with periodontal Ehlers-Danlos syndrome
W364C
the mutation is associated with periodontal Ehlers-Danlos syndrome
W435R
the mutation is associated with periodontal Ehlers-Danlos syndrome
Y302C
the mutation is associated with periodontal Ehlers-Danlos syndrome
additional information
-
by the point mutation of C1r - Arg-Phe - of the natural cleavage site Arg-Ile - the zymogen is stabilized, while the biological activity is not affected