3.4.21.41: complement subcomponent C1r

This is an abbreviated version!
For detailed information about complement subcomponent C1r, go to the full flat file.

Reaction

Selective cleavage of Lys(or Arg)-/-Ile bond in complement subcomponent C1s to form C_overbar_1s_ (EC 3.4.21.42) =

Synonyms

activated complement C1r, C1r, C1r protease, C1r serine protease, C1r-LP, C1rbar-esterase, complement C1r subcomponent-like protein, complement C1r, activated, complement protease C1r, complement subcomponent 1r, CUB, multiprotein complex C1, proteases C1r, serine protease C1r, Xld, xolloid

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.41 complement subcomponent C1r

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Results	in table
2	Activating Compound
958	AA Sequence
1	Application
1	CAS Registry Number
15	Cloned(Commentary)
5	Crystallization (Commentary)
9	Disease/ Diagnostics
2	Expression
10	General Information
2	General Stability
30	Inhibitors
2	kcat/KM [mM/s]
7	KM Value [mM]
4	Localization
4	Metals/Ions
9	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
46	Organism
16	PDB ID
4	pH Optimum
2	pI Value
17	Posttranslational Modification
21	Protein Variants
11	Purification (Commentary)
1	Reaction
1	Reaction Type
46	Reference
3	Renatured (Commentary)
30	Source Tissue
1	Storage Stability
45	Substrates and Products (Substrate)
17	Subunits
30	Synonyms
1	Temperature Optimum [°C]
3	Temperature Stability [°C]
5	Turnover Number [1/s]

Disease

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Disease on EC 3.4.21.41 - complement subcomponent C1r

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Carcinoma

Tumour serine proteases C1r and C1s as novel biomarkers and therapeutic targets in invasive sporadic and recessive dystrophic epidermolysis bullosa-associated cutaneous squamous cell carcinoma.

31486079

Carcinoma, Hepatocellular

Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein.

15385675

Carcinoma, Squamous Cell

Tumour serine proteases C1r and C1s as novel biomarkers and therapeutic targets in invasive sporadic and recessive dystrophic epidermolysis bullosa-associated cutaneous squamous cell carcinoma.

31486079

Infections

Importance of the prime subsites of the C1s protease of the classical complement pathway for recognition of substrates.

14674770

Neoplasms

Tumour serine proteases C1r and C1s as novel biomarkers and therapeutic targets in invasive sporadic and recessive dystrophic epidermolysis bullosa-associated cutaneous squamous cell carcinoma.

31486079

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